A5056357207- Parkinson's Disease Mechanisms and Treatments
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Neuroinflammation and Neurodegeneration Mechanisms
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Autophagy in Disease and Therapy
- Sleep and Wakefulness Research
- Nerve injury and regeneration
- COVID-19 diagnosis using AI
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Alzheimer's disease research and treatments
- RNA regulation and disease
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Neurological diseases and metabolism
- Mesenchymal stem cell research
- SARS-CoV-2 detection and testing
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
Hospital Clínico Universitario de Valencia
2025
Nanjing Agricultural University
2024-2025
Wuhan Red Cross Hospital
2020-2024
Union Hospital
2012-2024
Huashan Hospital
2024
Wuhan Union Hospital
2016-2022
Wuhan University
2017-2021
Renmin Hospital of Wuhan University
2020-2021
Abstract The outbreak of the novel coronavirus disease (COVID‐19) quickly spread all over China and to more than 20 other countries. Although virus (severe acute respiratory syndrome [SARS‐Cov‐2]) nucleic acid real‐time polymerase chain reaction (PCR) test has become standard method for diagnosis SARS‐CoV‐2 infection, these PCR kits have many limitations. In addition, high false‐negative rates were reported. There is an urgent need accurate rapid identify a large number infected patients...
<h3>Importance</h3> Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. <h3>Objective</h3> To evaluate the efficacy and adverse effects of convalescent therapy COVID-19. <h3>Design, Setting, Participants</h3> Open-label, multicenter, trial performed in 7 medical centers Wuhan, China, February 14, 2020, to April 1, final follow-up 28, 2020. The included 103 participants...
Hyperglycaemia is associated with an elevated risk of mortality in community-acquired pneumonia, stroke, acute myocardial infarction, trauma and surgery, among other conditions. In this study, we examined the relationship between fasting blood glucose (FBG) 28-day coronavirus disease 2019 (COVID-19) patients not previously diagnosed as having diabetes.We conducted a retrospective study involving all consecutive COVID-19 definitive outcome FBG measurement at admission from 24 January 2020 to...
Recent researches regarding to exosomal involvement in alpha-synuclein (α-syn) transmission relating the pathological process of Parkinson's disease (PD) have attracted considerable attention. It is highly desirable make clear diffusion and cellular uptake α-syn-associated exosomes underlying mechanism exosomes-involved communication synucleinopathy pathogenesis. To determine contribution initiation progression PD, plasma derived from PD patients were stereotaxically injected into striatum...
Autophagy-mediated self-digestion of cytoplasmic inclusions may be protective against neurodegenerative diseases such as Parkinson's disease (PD). However, excessive autophagic activation evokes programmed cell death.In this study, we aimed at exploring the role autophagy in pathogenesis rotenone-induced cellular and animal models for PD.Reactive oxygen species over-generation, mitochondrial membrane potential reduction or apoptosis rate elevation occurred a dose-dependent fashion...
Abstract Increasing evidence suggests that microglial activation is strongly linked to the initiation and progression of Parkinson’s disease. Cell-to-cell propagation α-synuclein pathology a highlighted feature disease, focus such research has been primarily on neurons. However, recent studies as well data contained herein suggest microglia, primary phagocytes in brain, play direct role spread pathology. Recent revealed plasma exosomes derived from disease patients (PD-EXO) carry...
Circadian disturbance is a common nonmotor complaint in Parkinson's disease (PD). The molecular basis underlying circadian rhythm PD poorly understood. Neuroinflammation has been identified as key contributor to pathology. In this study, we explored the potential link between core clock molecule Rev-erbα and microglia-mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome pathogenesis.We first examined diurnal rhythms changes inflammatory cytokines expression SN of MPTP-induced...
A clinically-related animal model of Parkinson's disease (PD) may enable the elucidation etiology and assist development medications. However, none current neurotoxin-based models recapitulates main clinical features or pathological hallmarks, such as dopamine (DA) neuron specificity degeneration Lewy body formation, which limits use these in PD research. To overcome limitations, we developed a rat by stereotaxically (ST) infusing small doses mitochondrial complex-I inhibitor, rotenone, into...
Since December 2019, novel coronavirus- (SARS-CoV-2) infected pneumonia (COVID-19) has rapidly spread throughout China. This study is aimed at describing the characteristics of COVID-19 patients in Wuhan.199 were admitted to Wuhan Red Cross Hospital China from January 24th March 15th. The cases divided into diabetic and nondiabetic groups according history taking antidiabetic drugs or by plasma fasting blood glucose level admission, difference between compared.Among 199 patients, 76 123...
An important pathophysiological component of Parkinson's Disease (PD) is circadian rhythm disorder, closely related to a decrease in circulated melatonin (MLT) level. It has been reported recently that retinoic acid-associated orphan nuclear receptor (RORα), for the potentiallyendogenous ligand MLT, plays an role various diseases. However, function RORα pathogenesis neurodegenerative diseases remains much unclear. Here, we showed cellular PD model expression was down-regulated 1 methyl 4...