A5100669904- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Estrogen and related hormone effects
- Metamaterials and Metasurfaces Applications
- Fungal Biology and Applications
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Microbial Natural Products and Biosynthesis
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Supercapacitor Materials and Fabrication
- Nerve injury and regeneration
- Advanced Glycation End Products research
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Plasmonic and Surface Plasmon Research
- Plant Pathogens and Fungal Diseases
- Advanced Antenna and Metasurface Technologies
Xi'an Medical University
2009-2025
Qilu Hospital of Shandong University
2017-2025
Third Affiliated Hospital of Zhengzhou University
2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Shanghai Institute of Hematology
2025
Harbin Institute of Technology
2024
Shandong Normal University
2018-2024
Shandong University
2002-2024
Nanjing University
2008-2024
Abstract Dynamical controls on terahertz (THz) wavefronts are crucial for many applications, but available mechanism requests tunable elements with sub-micrometer sizes that difficult to find in the THz regime. Here, different from local-tuning mechanism, we propose an alternative approach construct wavefront-control meta-devices combining specifically designed metasurfaces and globally tuned graphene layers. Coupled-mode-theory (CMT) analyses reveal serves as a loss drive whole meta-device...
Biotic elicitors can be used to stimulate the production of secondary metabolites in plants. However, limited information is available on effects biotic from endophytic fungi their host plant. Trichoderma atroviride D16 an fungus isolated root Salvia miltiorrhiza and previously reported produce tanshinone I (T-I) IIA (T-IIA). Here, extract mycelium (EM) polysaccharide fraction (PSF), produced by T. D16, growth metabolism S. hairy roots are reported. The results indicated that both EM PSF...
14,15-epoxyeicosatrienoic acid (14,15-EET) is an important lipid signaling molecule involved in the regulation of tumor metastasis, however, role and molecular mechanisms 14,15-EET activity breast cancer cell epithelial-mesenchymal transition (EMT) drug resistance remain enigmatic.The 14, 15-EET level serum or non-cancerous tissue from patients was measured by ELISA. qRT-PCR western blot analyses were used to examine expression integrin αvβ3. The adhesion, invasion explored adhesion...
The unrestricted control of circularly polarized (CP) terahertz (THz) waves is important in science and applications, but conventional THz devices suffer from issues bulky size low efficiency. Although Pancharatnam-Berry (PB) metasurfaces have shown strong capabilities to CP waves, transmission-mode PB realized the regime are less efficient, limiting their applications practice. Here, based on Jones matrix analysis, we design a tri-layer structure (thickness ~λ/5) experimentally demonstrate...
Autophagy-mediated self-digestion of cytoplasmic inclusions may be protective against neurodegenerative diseases such as Parkinson's disease (PD). However, excessive autophagic activation evokes programmed cell death.In this study, we aimed at exploring the role autophagy in pathogenesis rotenone-induced cellular and animal models for PD.Reactive oxygen species over-generation, mitochondrial membrane potential reduction or apoptosis rate elevation occurred a dose-dependent fashion...
A clinically-related animal model of Parkinson's disease (PD) may enable the elucidation etiology and assist development medications. However, none current neurotoxin-based models recapitulates main clinical features or pathological hallmarks, such as dopamine (DA) neuron specificity degeneration Lewy body formation, which limits use these in PD research. To overcome limitations, we developed a rat by stereotaxically (ST) infusing small doses mitochondrial complex-I inhibitor, rotenone, into...
Salvia miltiorrhiza is known for tanshinones and salvianolic acids, which have been shown to a protective effect against ROS, especially cardiovascular diseases other various ailments of human organs. Due the low yield their analogues in S. miltiorrhiza, multiple stimulation strategies developed improve production plant tissue cultures. Endophytic fungi reported form different relationships with host plants, including symbiotic, mutualistic, commensalistic, parasitic interactions. Thus we...
Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction caused by many pathological events, including neuroinflammation and oxidative stress damage. Increasing evidence suggests that parvalbumin (PV) interneurons play key role in the cognitive process, whereas of these has been implicated number major psychiatric disorders. Here, we aimed to investigate whether enhanced inflammation stress-mediated PV interneuron phenotype loss plays sepsis-induced impairments.Male C57BL/6 mice...
Two novel cytotoxic and antifungal constituents, (4S,6S)-6-[(1S,2R)-1, 2-dihydroxybutyl]-4-hydroxy-4-methoxytetrahydro-2H-pyran-2-one (1), (6S,2E)-6-hydroxy-3-methoxy-5-oxodec-2-enoic acid (2), together with three known compounds, LL-P880γ (3), LL-P880α (4), Ergosta-5,7,22-trien-3b-ol (5) were isolated from the metabolites of endophytic fungi Dendrobium officinale. The chemical structures determined based on spectroscopic methods. All compounds 1–5 evaluated by cytotoxicity effects. Our...
The detection of cancer cells in clinical samples is great interest for a range diagnostic applications, and separation enrichment low concentrations from complex sample matrices necessary efficient diagnostics. In the present study, new surface-modified iron oxide nanoparticles were synthesized lung by simple precipitation Fe(II) Fe(III) salts an aqueous ammonia solution, followed addition polyethylenimine (PEI). modified characterized X-ray diffractometry (XRD), transmission electron...
Abstract Estrogen receptor α (ERα) is a key regulator of breast growth and cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant cells. We employed an integrated approach, combining genome-wide mapping chromatin-bound with estrogen-induced transcript metabolic profiling, to demonstrate that reprograms upon estrogen stimulation, including changes aerobic glycolysis, nucleotide amino acid synthesis, choline (Cho) metabolism. Cho...
Circularly polarized Bessel beams (BBs) are important in biomolecule-sensing-related applications, but the available generators too bulky size and/or exhibit low efficiencies. Here, we design and fabricate ultra-thin (∼λ/6) transmissive Pancharatnam-Berry metasurfaces perform near-field scanning measurements to show that they can generate circularly BBs within a frequency window of 10.7–12.3 GHz. We experimentally demonstrate generated self-healing effect, illustrating their non-diffraction...