A5015595115- Genomic variations and chromosomal abnormalities
- Parkinson's Disease Mechanisms and Treatments
- Genomics and Rare Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Genetic Syndromes and Imprinting
- Cerebrovascular and Carotid Artery Diseases
- Prenatal Screening and Diagnostics
- Bipolar Disorder and Treatment
- Acute Ischemic Stroke Management
- Hemoglobinopathies and Related Disorders
- Nuclear Receptors and Signaling
- Chromosomal and Genetic Variations
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Congenital heart defects research
- Radiomics and Machine Learning in Medical Imaging
- Iron Metabolism and Disorders
- Diet and metabolism studies
- RNA modifications and cancer
- Viral Infectious Diseases and Gene Expression in Insects
- 3D Printing in Biomedical Research
- Neuroscience and Neuropharmacology Research
- RNA regulation and disease
- Renal and related cancers
Second Affiliated Hospital of Fujian Medical University
2017-2025
Fujian Medical University
2015-2025
McLean Hospital
2019-2020
Huazhong University of Science and Technology
2009-2015
Union Hospital
2015
Union Hospital
2009-2012
The Ohio State University
2000-2004
Microglial polarization and the subsequent neuroinflammatory response are contributing factors for traumatic brain injury (TBI)-induced secondary injury. High mobile group box 1 (HMGB1) mediates activation of NF-κB pathway, it is considered to be pivotal in late response. Activation HMGB1/NF-κB pathway closely related HMGB1 acetylation, which regulated by sirtuin (SIRT) family proteins. Omega-3 polyunsaturated fatty acids (ω-3 PUFA) known have antioxidative anti-inflammatory effects. We...
Microglial activation and the subsequent inflammatory response in central nervous system play important roles secondary damage after traumatic brain injury (TBI). High-mobility group box 1 (HMGB1) protein, an mediator late responses, interacts with transmembrane receptor for advanced glycation end products (RAGE) toll-like receptors (TLRs) to activate downstream signaling pathways, such as nuclear factor (NF)-κB pathway, leading a cascade amplification of which are related neuronal TBI....
A clinically-related animal model of Parkinson's disease (PD) may enable the elucidation etiology and assist development medications. However, none current neurotoxin-based models recapitulates main clinical features or pathological hallmarks, such as dopamine (DA) neuron specificity degeneration Lewy body formation, which limits use these in PD research. To overcome limitations, we developed a rat by stereotaxically (ST) infusing small doses mitochondrial complex-I inhibitor, rotenone, into...
3-methyl-1-phenyl-2-pyrazolin-5-one (edaravone), an effective free radical scavenger, provides neuroprotection in stroke models and patients. In this study, we investigated its neuroprotective effects a chronic rotenone rat model for Parkinson's disease. Here showed that five-week treatment with edaravone abolished rotenone's activity to induce catalepsy, damage mitochondria degenerate dopamine neurons the midbrain of rotenone-treated rats. This abolishment was attributable at least partly...
Objective The aim of this study is to investigate the clinical value radiomics based on non-enhanced head CT in prediction hemorrhage transformation acute ischemic stroke (AIS). Materials and methods A total 140 patients diagnosed with AIS from January 2015 August 2022 were enrolled. Radiomic features infarcted areas images extracted using ITK-SNAP. max-relevance min-redundancy (mRMR) least absolute shrinkage selection operator (LASSO) used select features. signature was then constructed by...
Several studies have shown functional improvements, neuroprotective, and neuroregenerative effects after mesenchymal stem cells transplantation to parkinsonian animal models. However, questions remain about the safety, feasibility, long-term efficacy of this approach. In study, we investigated migration, therapeutic, tumorigenesis, epileptogenic human umbilical cord stromal (HUMSCs) 1 year into rotenone-induced hemiparkinsonian rats. Our data indicated that DiI-labeled HUMSCs migrated in...
The primary factor for cardiovascular disease and upcoming events is atherosclerosis. Recently, carotid plaque texture, as observed on ultrasonography, varied difficult to classify with the human eye due substantial inter-observer variability. High-resolution magnetic resonance (MR) imaging offers naturally superior soft tissue contrasts computed tomography (CT) combining different contrast weightings may provide more useful information. Radiation freeness operator independence are two...
Few existing reports have investigated the copy number variants (CNVs) in fetuses with central nervous system (CNS) anomalies. To gain further insights into genotype-phenotype relationship, we conducted chromosomal microarray analysis (CMA) to reveal pathogenic CNVs (pCNVs) that were associated fetal CNS We enrolled 5,460 pregnant women different high-risk factors who had undergone CMA. Among them, 57 subjects anomalies recruited. Of anomalies, 23 given amniocentesis, which involved...
Objectives Parkinson’s disease (PD) has become a public health concern with global ageing. With focus on PD, this study sought to project its burden and trends at the national, regional worldwide levels between 1990 2021. Study design Population-based study. Methods The Global Burden of Disease (GBD) 2021 provided PD data. GBD data are considered globally regionally representative, as it integrates multiple sources employs standardised estimation methods. age-standardised rate (ASR)...
To determine the correlation between intracranial atherosclerotic stenosis and high-sensitivity C-reactive protein (hs-CRP) levels in elderly patients with cerebral infarction. We performed a retrospective assessment of acute minor ischemic stroke aged over 60 at our institution from January 2021 to May 2023. A thorough computed tomography angiography (CTA) was conducted for each participant. The were classified into four categories according site arteries: (1) (ICAS), (2) extracranial...
<title>Abstract</title> This study developed and compared single-sequence multimodal imaging omics models for Parkinson's disease (PD) classification using 3.0T MRI scans (T1WI, T2-FLAIR) from 160 PD patients (82 tremor-type, 78 non-tremor-type) 100 healthy controls. Regions of interest included the Hippocampus, Substantia Nigra, Red Nucleus, Thalamus, Amygdala. Data were split into training/test sets (8:2), with Least Absolute Shrinkage Selection Operator (LASSO) feature selection Support...
Context.— Identification of rare thalassemia variants requires a combination multiple diagnostic technologies. Objective.— To investigate new approach comprehensive analysis alleles based on third-generation sequencing (TGS) for identification α- and β-globin gene variants. Design.— Enrolled in this study were 70 suspected carriers Routine gap–polymerase chain reaction DNA used to detect variants, TGS technology was performed identify Results.— Twenty-three cases that carried genes...
The neuroinflammatory response mediated by microglial activation plays an important role in the secondary nerve injury of traumatic brain injury. post-transcriptional modification N 6 -methyladenosine (m A) is ubiquitous immune central nervous system. fat mass and obesity (FTO)-related protein catalyzes demethylation m A modifications on mRNA widely expressed various tissues, participating regulation multiple diseases' biological processes. However, FTO subsequent after unclear. In this...
Despite the well-established association between apolipoprotein B/apolipoprotein A1 (apoB/apoA1) ratio and ischemic stroke, its specific relationship with underlying vascular pathologies contributing to stroke remains poorly understood. This study aims investigate apoB/apoA1 intracranial or extracranial atherosclerosis. We enrolled 408 patients acute who had never been treated statins fibrates. Based on images from computed tomography angiography (CTA), were categorized into four groups:...
Mutations of the glucocerebrosidase (GBA) gene have reportedly been associated with Parkinson disease (PD) in various ethnic populations such as Singaporean, Japanese, Formosan, Canadian, American, Portuguese, Greek, Brazilian, British, Italian, Ashkenazi Jewish, southern and southwestern Chinese. The purpose this study is to determine central China whether or not reported GBA mutations remain PD. In project, we conducted a controlled cohort 208 Chinese PD patients 298 controls for three...
Abstract Background Limited research has been conducted regarding the elucidation of genotype–phenotype correlations within 20q13.33 region. The association microdeletion remains inadequately understood. In present study, two novel cases were introduced, with objective enhancing understanding relationship. Methods Two unrelated patients various abnormal clinical phenotypes from Fujian province Southeast China enrolled in study. Karyotype analysis and chromosomal microarray (CMA) performed to...