A5101915885- Lipid metabolism and disorders
- Obstructive Sleep Apnea Research
- Cancer, Hypoxia, and Metabolism
- Gamma-ray bursts and supernovae
- Metabolism, Diabetes, and Cancer
- Aortic aneurysm repair treatments
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Neuroscience of respiration and sleep
- Aortic Disease and Treatment Approaches
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Cardiovascular Function and Risk Factors
- Extracellular vesicles in disease
- Immune cells in cancer
- Remote Sensing in Agriculture
- Smart Agriculture and AI
- Chemical Synthesis and Reactions
- High Altitude and Hypoxia
- Sirtuins and Resveratrol in Medicine
Beijing Anzhen Hospital
2017-2025
Capital Medical University
2017-2025
Shanghai Academy of Agricultural Sciences
2009-2024
Ministry of Agriculture and Rural Affairs
2022-2024
First Affiliated Hospital of GuangXi Medical University
2021-2024
Guangxi Medical University
2021-2024
Tsinghua University
2017-2024
East China University of Science and Technology
2022-2024
Air Force Medical University
2022-2024
Agricultural Information Institute
2024
Microplastics have been detected in human stool, lungs, and placentas, which direct exposure to the external environment through various body cavities, including oral/anal cavity uterine/vaginal cavity. Crucial data on microplastic completely enclosed organs are still lacking. Herein, we used a laser infrared chemical imaging system scanning electron microscopy investigate whether microplastics exist heart its surrounding tissues. Microplastic specimens were collected from 15 cardiac surgery...
On 2018 Feb. 4.41, the All-Sky Automated Survey for SuperNovae (ASAS-SN) discovered ASASSN-18bt in K2 Campaign 16 field. With a redshift of z=0.01098 and peak apparent magnitude B_{max}=14.31, is nearest brightest SNe Ia yet observed by Kepler spacecraft. Here we present discovery ASASSN-18bt, light curve, pre-discovery data from ASAS-SN Asteroid Terrestrial-impact Last Alert System (ATLAS). The early-time curve has an unprecedented 30-minute cadence photometric precision SN~Ia it...
A novel approach to the Cu-catalyzed cyanation of simple arenes using acetonitrile as an attractive cyano source has been documented. The C-H functionalization without directing groups involves a sequential iodination/cyanation give desired aromatic nitriles in good yields. highly efficient Cu/TEMPO system for C-CN bond cleavage discovered. TEMPO is used cheap oxidant and enables reaction be catalytic copper. Moreover, TEMPOCH2CN 6 identified active cyanating agent shows high reactivity...
Low temperature is a type of abiotic stress affecting the tomato ( Solanum lycopersicum ) growth. Understanding mechanisms and utilization exogenous substances underlying plant tolerance to cold would lay foundation for improving resilience in this important crop. Our study aiming investigate effect glycine betaine (GB) on seedlings increase low temperatures. By treating with GB under stress, we found that 30 mmol/L can significantly improve seedlings. Exogenous influence enzyme activity...
Background: Endothelial barrier dysfunction plays a key role in atherosclerosis progression. The primary pathology of obstructive sleep apnea-hypopnea syndrome is chronic intermittent hypoxia (IH), which induces reactive oxygen species (ROS) overproduction, endothelial injury, and atherosclerosis. Salidroside, typical pharmacological constituent Rhodiola genus, has documented antioxidative, cardiovascular protective effects. However, whether salidroside can improve IH-aggravated not been...
Abstract Aims Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose inflammation, and cell proliferation migration. Clinical studies have indicated that circulating ANGPTL8 concentrations are increased patients with hypertension positively associated blood pressure. deficiency ameliorates pressure mice treated chronic intermittent hypoxia. Currently, little is known regarding the pathophysiological role of vascular smooth muscle (VSMC)-derived hypertensive...
The cyanation of arylboronic acids by using acetonitrile as the "CN" source has been achieved under a Cu(cat.)/TEMPO system (TEMPO=2,2,6,6-tetramethylpiperidine N-oxide). broad substrate scope includes variety electron-rich and electron-poor acids, which react well to give cyanated products in high excellent yields. Mechanistic studies reveal that TEMPO-CH2 CN, generated situ, is an active cyanating reagent, shows reactivity for formation CN(-) moiety. Moreover, TEMPO acts cheap oxidant...
Obstructive sleep apnea-hypopnea syndrome, a breathing disorder in which chronic intermittent hypoxia (CIH) is the primary pathology, associated with multiple cardiovascular diseases. However, whether and how CIH may affect cardiac remodeling following myocardial infarction (MI) remains unknown.To determine exposure at different periods of MI exacerbate post-MI heart failure to identify mechanisms underlying CIH-exacerbated remodeling.Adult male mice were subjected (4 weeks) without or 8...
Abstract Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) a hormone involved in the regulation of lipid metabolism and inflammation. However, relationship between ANGPTL8 TAD remains unknown. Methods This case-control study included 78 patients 72 controls. The diameter was evaluated computed tomography used to assess severity. Circulating levels were measured enzyme-linked immunosorbent assay. Associations with...
The identification of cucumber fruit is an essential procedure in automated harvesting greenhouses. In order to enhance the ability object detection models for harvesting, extended RGB image dataset (n = 801) with 3943 positive and negative labels was constructed. Firstly, twelve channels four color spaces (RGB, YCbCr, HIS, La*b*) were compared through ReliefF method choose channel highest weight. Secondly, converted pseudo-color chosen (Cr channel) pre-train YOLOv5s model before formal...
AT hook DNA-binding protein (AHDC1/Gibbin) is a nuclear with currently undefined function and structure. De novo nonsense or frameshift mutations in the AHDC1 gene have been identified as causative factor for Xia-Gibbs syndrome (XGS, OMIM#615829) 2014, neurodevelopmental disorder characterized by intellectual disability developmental delay (1). XGS occurs infancy often accompanied hypotonia, followed global expressive language delays, ultimately leading to disabilities (2).Whole-exome...
<title>Abstract</title> This study developed and compared single-sequence multimodal imaging omics models for Parkinson's disease (PD) classification using 3.0T MRI scans (T1WI, T2-FLAIR) from 160 PD patients (82 tremor-type, 78 non-tremor-type) 100 healthy controls. Regions of interest included the Hippocampus, Substantia Nigra, Red Nucleus, Thalamus, Amygdala. Data were split into training/test sets (8:2), with Least Absolute Shrinkage Selection Operator (LASSO) feature selection Support...
Abstract Background Fenofibrate, a PPAR alpha agonist, has been widely used in clinics as lipid-regulating agent. is known to be expressed many organs including pancreatic beta cells and regulate genes involved fatty acid metabolism. Some reports based on cell lines or animals have provided evidences that agonists may affect (increased suppressed) insulin secretion, several studies are producing interesting but still debated results. Methods In this research, we investigated the long term...
Thoracic aortic dissection (TAD) has a high mortality rate. Intermittent hypoxia (IH) triggers both harmful and beneficial effects in numerous physiological systems. The of IH on TAD development were explored mouse model.β-Aminopropionitrile monofumarate (BAPN) was used to induce C57BL/6 mice. Three week old male mice treated with 1 g/kg/day BAPN drinking water for four weeks simultaneously subjected (n = 30) (21%-5% O2, 90 s/cycle, 10 h/day, + group) or normoxia (21% 24 group). Human VSMCs...
Background High-fat diet (HFD)-induced hyperlipidemia, which is associated with gut microbiota disturbances, remains a major public health challenge. Glycerolipid metabolism responsible for lipid synthesis and thus involved in the development of hyperlipidemia. However, possible association between HFD-modulated microbiome glycerolipid pathway unclear. Methods Hamsters were fed HFD 4 weeks to establish hyperlipidemia model. Fecal, plasma liver samples collected from hamsters or normal chow...
Background and aimsAngiopoietin-like protein 8 (ANGPTL8) is a hormone involved in regulating lipid metabolism. Patients with coronary artery disease have markedly higher plasma levels of ANGPTL8 than controls; however, the role atherosclerosis has not been explored. Therefore, we explored effects on development mouse model.MethodsWe induced experimental ApoE−/− mice ANGPTL8-knockdown. ANGPTL8-overexpression mice. We also mechanism using macrophages.ResultsANGPTL8 expression was increased...
Increased energy intake and reduced physical activity can lead to obesity, diabetes metabolic syndrome. Transcriptional modulation of networks has become a focus current drug discovery research into the prevention treatment disorders associated with surplus obesity. Tang-Nai-Kang (TNK), mixture five herbal plant extracts, been shown improve abnormal glucose metabolism in patients pre-diabetes. Here, we report phenotype SHR.Cg-Leprcp/NDmcr (SHR/cp) rats treated TNK. Pre-diabetic SHR/cp were...