A5025802796- Lipid metabolism and disorders
- Obstructive Sleep Apnea Research
- Gut microbiota and health
- Aortic aneurysm repair treatments
- Cancer-related molecular mechanisms research
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Aortic Disease and Treatment Approaches
- Sleep and related disorders
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Sinusitis and nasal conditions
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cholesterol and Lipid Metabolism
- Hip disorders and treatments
- Nitric Oxide and Endothelin Effects
- Macrophage Migration Inhibitory Factor
- Regional Development and Environment
- Heart Rate Variability and Autonomic Control
- Atherosclerosis and Cardiovascular Diseases
- Aortic Thrombus and Embolism
Yanbian University Hospital
2025
Capital Medical University
2018-2024
Beijing Anzhen Hospital
2018-2024
Huazhong University of Science and Technology
2024
Beijing Institute of Water
2020-2022
Beijing Shijitan Hospital
2021
Ministry of Education of the People's Republic of China
2020
Harbin Medical University
2013
With the establishment of heart-gut axis concept, accumulating studies suggest that gut microbiome plays an important role in pathogenesis cardiovascular diseases. Yet, little evidence has been reported characterizing microbiota shift atrial fibrillation.We include result global alterations occur intestinal a cohort 50 patients with fibrillation and matched controls based on strategy metagenomic metabolomic analyses.The dramatic elevation microbial diversity specific perturbation...
Abstract Background Accumulating studies have suggested that gut microbiota (GM) dysbiosis and vitamin D3 deficiency each play an important role during the progression of hypertension (HTN). However, few characterized underlying interaction between GM shift in HTN patients. Hypothesis This study aimed to evaluate possible crosstalk D pathogenesis HTN. Methods In a cohort 34 patients 15 healthy controls, we analyzed fecal products, composition, D3. Results Vitamin was significantly decreased...
Abstract Aims Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose inflammation, and cell proliferation migration. Clinical studies have indicated that circulating ANGPTL8 concentrations are increased patients with hypertension positively associated blood pressure. deficiency ameliorates pressure mice treated chronic intermittent hypoxia. Currently, little is known regarding the pathophysiological role of vascular smooth muscle (VSMC)-derived hypertensive...
Alternations of gut microbiota (GM) in atrial fibrillation (AF) with elevated diversity, perturbed composition and function have been described previously. The current work aimed to assess the association GM AF recurrence (RAF) after ablation based on metagenomic sequencing metabolomic analyses construct a GM-based predictive model for RAF. Compared non-AF controls (50 individuals), profile were significantly altered between patients recurrent (17 individuals) non-RAF group (23 individuals)....
Abstract Purpose Thoracic aortic dissection (TAD) is characterized by an inflammatory response. Angiopoietin-like protein 8 (ANGPTL8) a hormone involved in the regulation of lipid metabolism and inflammation. However, relationship between ANGPTL8 TAD remains unknown. Methods This case-control study included 78 patients 72 controls. The diameter was evaluated computed tomography used to assess severity. Circulating levels were measured enzyme-linked immunosorbent assay. Associations with...
Chronic intermittent hypoxia (CIH) is the prominent signature of highly prevalent obstructive sleep apnea (OSA) pathophysiology, which leads to increased risk and aggravation atherosclerotic cardiovascular diseases. However, whether intestinal microbiota implicated in mechanisms linking CIH arteriosclerosis (AS) pathogenesis remains unclear. The association with development altered gut (GM) may provide opportunity develop preventive strategies for reduction. Animal models apolipoprotein...
Background High-fat diet (HFD)-induced hyperlipidemia, which is associated with gut microbiota disturbances, remains a major public health challenge. Glycerolipid metabolism responsible for lipid synthesis and thus involved in the development of hyperlipidemia. However, possible association between HFD-modulated microbiome glycerolipid pathway unclear. Methods Hamsters were fed HFD 4 weeks to establish hyperlipidemia model. Fecal, plasma liver samples collected from hamsters or normal chow...
Background and aimsAngiopoietin-like protein 8 (ANGPTL8) is a hormone involved in regulating lipid metabolism. Patients with coronary artery disease have markedly higher plasma levels of ANGPTL8 than controls; however, the role atherosclerosis has not been explored. Therefore, we explored effects on development mouse model.MethodsWe induced experimental ApoE−/− mice ANGPTL8-knockdown. ANGPTL8-overexpression mice. We also mechanism using macrophages.ResultsANGPTL8 expression was increased...
Abstract Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose inflammation, and cell proliferation migration. Clinical studies have indicated that circulating ANGPTL8 levels are increased patients with thoracic aortic dissection (TAD). TAD shares several risk factors abdominal aneurysm (AAA). However, the role of AAA pathogenesis has never been investigated. Here, we investigated effect knockout on ApoE−/− mice. ApoE−/−ANGPTL8−/− mice were generated by...
Abstract Chronic intermittent hypoxia (CIH) is the primary feature of obstructive sleep apnoea (OSA), a crucial risk factor for cardiovascular diseases. Long non‐coding RNAs (lncRNAs) in myocardial infarction (MI) pathogenesis have drawn considerable attention. However, whether CIH participates modulation lncRNA profiles during MI yet unclear. To investigate influence on MI, cardiac damage was assessed by histology and echocardiography, mRNA integrated microarrays were screened. mouse model...
Abstract Purpose Hyperlipidemia is the most important early atherosclerosis and coronary artery disease (CAD) indicator. Angiopoietin-like proteins (ANGPTLs) 3, 4, 8 are lipid dysfunction markers that may be linked to CAD. We investigated whether these circulating ANGPTLs associated with CAD in patients obstructive sleep apnea (OSA). Methods A total of 327 individuals participated this study: 221 OSA CAD, 50 alone, 56 controls. The Gensini Score was used assess severity Serum ANGPTL3,...
Hypertension is a complicated disorder with multifactorial etiology and high heritability. Our previous work has identified L3MBTL4 as novel susceptibility gene for the development of essential hypertension, accompanied activation p38/JNK. Yet, little evidence been reported whether p38/JNK contributed directly to L3MBTL4-induced vascular remodeling exploring potential mechanism in smooth muscle cells (VSMCs). We evaluated contribution on proliferation, migration, phenotype changes VSMCs...
Background/Aims: Copper is an essential trace element for normal cellular function and contributes to critical physiological or pathological processes. The aim of the study was investigate effects copper on vascular tone rat mesenteric artery compare noradrenaline (NA) high K+ induced vasoconstriction. Methods: arteries were isolated vessel measured by using multi wire myograph system in vitro. Blood pressure carotid rabbits data acquisition analysis vivo. Results: dose-dependently blunted...
Atherosclerosis is the pathological basis of cardiovascular disease. Obstructive sleep apnea (OSA) aggravates atherosclerosis, and chronic intermittent hypoxia (CIH) as a prominent feature OSA plays an important role during process atherosclerosis. The mechanisms CIH in development atherosclerosis remain unclear. In current study, we used microarray to investigate differentially expressed mRNAs long non-coding RNAs (lncRNAs) aorta from five groups ApoE-/- mice fed with high-fat diet exposed...
Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality globally. Hypercholesterolemia accelerates atherosclerotic development and an independent modifiable risk factor for ASCVD. Reducing cholesterol levels effective in preventing Acetyl-L-carnitine (ALC) endogenous molecule that plays a primary role energy metabolism; however, its effect on metabolism remains unclear. Methods We collected plasma samples clinical data from 494 individuals with...
Obstructive sleep apnea (OSA) is a major risk factor for cardiovascular mortality. Apnea-induced chronic intermittent hypoxia (CIH) primary pathophysiological manifestation of OSA that promotes various alterations, such as aortic vascular remodeling. In this study, we investigated the association between angiopoietin-like proteins 8 (ANGPTL8) and CIH-induced remodeling in mice.C57BL/6J male mice were divided into four groups: Normoxia group, ANGPTL8-/- CIH + group. Mice normoxia group...
Abdominal aortic aneurysm (AAA) is a potentially life-threatening vascular disease primarily in the male elderly population, but there lack of approved medical therapies to prevent progression and rupture AAA. Activating Transcription Factor 4 (ATF4) has been established be involved cardiovascular diseases, such as heart failure calcific valve disease. However, role ATF4 pathogenesis AAA remains unclear. We found that expression was significantly increased patients with mouse models mainly...
Obstructive sleep apnea (OSA) can aggravate blood pressure and increase the risk of cardiovascular diseases in hypertensive individuals, yet underlying pathophysiological process is still incompletely understood. More importantly, OSA remains a significantly undiagnosed condition. In this study, total 559 patients with without were included. Metabolome lipidome-wide analyses performed to explore processes hypertension comorbid derive potential biomarkers for diagnosing subjects. Compared...