A5074884410- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Congenital heart defects research
- Signaling Pathways in Disease
- RNA modifications and cancer
- Galectins and Cancer Biology
- Immune cells in cancer
- Renal cell carcinoma treatment
- Cholesterol and Lipid Metabolism
- Lipid metabolism and disorders
- Cardiomyopathy and Myosin Studies
- RNA regulation and disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolomics and Mass Spectrometry Studies
- Peroxisome Proliferator-Activated Receptors
- Ferroptosis and cancer prognosis
- Telomeres, Telomerase, and Senescence
- Genetics and Neurodevelopmental Disorders
- Histone Deacetylase Inhibitors Research
- Lipoproteins and Cardiovascular Health
Guangdong Medical College
2020-2025
Beijing Anzhen Hospital
2023-2024
Capital Medical University
2023-2024
ABSTRACT Rnd3 is a small Rho‐GTPase that has been implicated in various cardiovascular diseases. Yet, its role diabetes‐induced cardiomyocyte senescence remains unknown. Here we tested the of and diabetic cardiomyopathy (DCM). The expression was found to be reduced peripheral blood mononuclear cells from patients correlated negatively with age but positively cardiac function. In 96‐week‐old Sprague Dawley (SD) rats, function impaired, accompanied by an increased number SA‐β‐gal‐positive...
Abstract BACKGROUND Rnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role diabetes-induced cardiomyocyte senescence unclear. This study aims to investigate the of Rnd3 diabetes cardiomyopathy (DCM). METHODS expression was assessed human tissue using qPCR, and correlation with clinical parameters analyzed. Senescence-associated secretory phenotype (SASP)-related marker determined heart from juvenile/mature mice streptozotocin-induced diabetic Sprague–Dawley...
Background Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality globally. Hypercholesterolemia accelerates atherosclerotic development and an independent modifiable risk factor for ASCVD. Reducing cholesterol levels effective in preventing Acetyl-L-carnitine (ALC) endogenous molecule that plays a primary role energy metabolism; however, its effect on metabolism remains unclear. Methods We collected plasma samples clinical data from 494 individuals with...
Abnormal epigenetic modification is closely related to the occurrence and development of cardiovascular diseases. The SET domain (SETD) family an important modifying enzyme containing SETD. They mainly affect gene expression by methylating H3K4, H3K9, H3K36 H4K20. Additionally, SETD catalyzes methylation non-histone proteins, thereby affects signal transduction activator transcription (STAT) 1, Wnt/β-catenin, hypoxia-inducible factor (HIF)-1α Hippo/YAP pathways. has following regulatory...
Abstract Purpose: Epigenetic modifications have important impacts on the biological functions of cells. This study explored effects SET domain-containing protein (SETD)4, a histone lysine methyltransferase, general bone marrow-derived macrophages (BMMs). Materials and Methods: We employed CRISPR/Cas9 technology-edited mouse model. After isolated from SETD4 knockout (KO) Wild-type (WT) mice, BMMs were maintained identified. Then, serials in vitro experiments performed to test levels...
Abstract This study explored the effects of SET domain-containing protein (SETD)4, a histone lysine methyltransferase, on general biological functions bone marrow-derived macrophages (BMMs). BMMs from SETD4 knockout (KO) mice exhibited significant inhibition monomethylation, dimethylation or trimethylation histones H3K4, H3K36, H3K79 and H4K20; enhancement proliferation, EdU-positive cell ratio, Ki67 mRNA levels, ability to form vascular structures; attenuation migration ability. After...
Familial hypercholesterolemia (FH) is a lipoprotein disorder characterized by elevated plasma levels of low-density cholesterol (LDL-C) and an increased risk premature atherosclerotic cardiovascular disease. Recent evidences have shown that several glycerophospholipid species were markedly altered in experimental FH animals exhibited diverse bioactivities. Nevertheless, the profiles their associated biological implications human remain largely unknown. In this study, we sought to...
Abstract Background: Epigenetic modification is a crucial mechanism affecting the biological function of stem cells. SETD4 histone methyltransferase, and its role in bone marrow mesenchymal cells (BMSCs) currently unknown. This work was aimed to reveal as well impacts on genomic methylation profiles BMSCs. Methods: BMSCs were isolated form knockout (KO) wild type (WT) mice that established by CRISPR/Cas9 technology. The cell proliferation, migration, myogenic differentiation angiogenesis...
Abstract Background Epigenetic modifications have important impacts on the biological functions of cells. This study explored effects SET domain-containing protein (SETD)4, a histone lysine methyltransferase, general bone marrow-derived macrophages (BMMs). Methods We employed CRISPR/Cas9 technology-edited mouse model. After isolated from SETD4 knockout (KO) and Wild-type (WT) mice, BMMs were maintained identified. Then, serials in vitro experiments performed to test levels methylation sites...
Abstract Background Stonin 1 (STON1) is an endocytic protein but its role in cancer remains unclear. Here, we investigated the of STON1 kidney renal clear cell carcinoma (KIRC). Methods We undertook bioinformatics analyses a series public databases to determine expression and clinical significance KIRC focused on STON1-related immunomodulator survival signatures. A nomogram model integrating clinicopathological characteristics risk scores for was established validated. Results Through TGCA...