A5100398505- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Fungal Infections and Studies
- Hepatitis C virus research
- Antifungal resistance and susceptibility
- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Nail Diseases and Treatments
- Liver Disease and Transplantation
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Pneumonia and Respiratory Infections
- Molecular Biology Techniques and Applications
- Infectious Diseases and Mycology
- Autophagy in Disease and Therapy
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis Viruses Studies and Epidemiology
Zhejiang University
2008-2025
Guangzhou Medical University
2012-2025
First Affiliated Hospital of Guangzhou Medical University
2014-2025
First Affiliated Hospital Zhejiang University
2025
Pfizer (United States)
2024-2025
Institute of Microbiology
2024
State Key Laboratory of Respiratory Disease
2009-2024
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Hebei University of Technology
2024
Shandong University
2021-2024
Abstract The outbreak of the novel coronavirus disease (COVID‐19) quickly spread all over China and to more than 20 other countries. Although virus (severe acute respiratory syndrome [SARS‐Cov‐2]) nucleic acid real‐time polymerase chain reaction (PCR) test has become standard method for diagnosis SARS‐CoV‐2 infection, these PCR kits have many limitations. In addition, high false‐negative rates were reported. There is an urgent need accurate rapid identify a large number infected patients...
<b>Humoral immune response to SARS-CoV-2 showed an early of IgA, instead IgM, in COVID-19 patients. As highlighted by this study, enhanced IgA responses observed severe might confer damaging effects COVID-19.</b>https://bit.ly/3fA7c1I
Severe Community Acquired Pneumonia (SCAP) challenges public health globally. Considerable improvements in molecular pathogen testing emerged the last few years. Our prospective study combinedly used traditional culture, antigen tests, PCR and mNGS SCAP identification with clinical outcomes. From June 2018 to December 2019, we conducted a multi-centre 17 hospitals of patients within 48 hours emergency room stay or hospitalization China. All data were uploaded into an online database. Blood,...
ADVERTISEMENT RETURN TO ISSUEPREVFeaturesNEXTBeyond the t-Test: Statistical Equivalence TestingGiselle B. Limentani, Moira C. Ringo, Feng Ye, Mandy L. Bergquist, and Ellen O. MCSorleyCite this: Anal. Chem. 2005, 77, 11, 221 A–226 APublication Date (Web):June 1, 2005Publication History Published online1 June 2005Published inissue 1 2005https://pubs.acs.org/doi/10.1021/ac053390mhttps://doi.org/10.1021/ac053390mnewsACS Publications. This publication is available under these Terms of Use....
Paclitaxel is recommended as a first-line chemotherapeutic agent against ovarian cancer, but drug resistance becomes major limitation of its success clinically. The key molecule or mechanism associated with paclitaxel in cancer still remains unclear. Here, we showed that TXNDC17 screened from 356 differentially expressed proteins by LC-MS/MS label-free quantitative proteomics was more highly paclitaxel-resistant cells and tissues, the high expression poorer prognostic factors exhibited...
Patients with coronavirus disease 2019 (COVID-19) exhibit a spectrum of respiratory symptoms like cough and dyspnea.1-3 Airway mucus is an adhesive viscoelastic gel composed mostly high-molecular-weight mucous glycoproteins water, which important in maintaining lung function health, pathological hypersecretion may cause airway obstruction lead to distress. Mucin (MUC) are the major macromolecular components mucus, classified into two types: gel-forming secreted MUC5AC membrane-tethered...
Apatinib, a novel tyrosine kinase inhibitor (TKI), has been confirmed for its efficacy and safety in the treatment of advanced gastric carcinoma some other solid tumors. However, direct functional mechanisms tumor lethality mediated by apatinib have not yet fully characterized, precise drug resistance are largely unknown. Here, this study, we demonstrated that could induce both apoptosis autophagy human colorectal cancer (CRC) via mechanism involved endoplasmic reticulum (ER) stress....
Abstract Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits further applications. To identify MSC subpopulations and clarify relationships, we performed mapping bone-marrow-derived MSCs through single-cell RNA (scRNA) sequencing. In our study, three main subpopulations, namely, the stemness subpopulation, functional proliferative were identified using marker genes bioinformatic analyses. Developmental trajectory analysis showed that...
BackgroundPapanicolaou (Pap) triage, with high specificity, has been recommended for primary Human papillomavirus (HPV) testing but is flawed by poor sensitivity and cytologist dependence. We evaluated the potential role of microRNA (miRNA) detection in cervical exfoliated cells HPV-positive women from a clinic-based population.
Benign or malignant lesions caused by Human papillomavirus (HPV) produce considerable health burden worldwide. Since limited cross-protection would be offered between HPV types, heterogeneity in type-specific distribution should taken into account when predicting the effect of current prophylactic vaccines and forming basic for second-generation targeted to specific regions. Here, we investigated prevalence cervical infection, as well predictors concerned, Zhejiang Province, southeast...
This study used the Global Burden of Disease data (2010-2021) to analyze rates and trends point prevalence, annual incidence, years lived with disability (YLDs) for metabolic dysfunction-associated steatotic liver disease (MASLD) in 204 countries. Total numbers age-standardized per 100,000 population MASLD YLDs were compared across regions countries by age, sex, sociodemographic index (SDI). Smoothing spline models evaluate relationship between burden SDI. Estimates reported uncertainty...
Bivalent RSV prefusion F subunit vaccine (RSVpreF), comprised of equal quantities stabilized antigens from the major circulating subgroups (RSV A, B), is licensed for prevention RSV-associated lower respiratory tract illness (LRTI) in older adults and maternal vaccination LRTI infants. To support licensure large-scale manufacturing, this lot consistency study was conducted to demonstrate equivalence immunogenicity across 3 RSVpreF lots. This phase 3, multicenter, parallel-group,...
Abstract To screen out potential prognostic hub genes for adult patients with sepsis via RNA sequencing and construction of a microRNA–mRNA–PPI network investigate the localization these in peripheral blood monocytes. The 33 subjects was subjected to microRNA mRNA using high-throughput sequencing, differentially expressed (DEGs) microRNAs (DEMs) were identified by bioinformatics. Single-cell transcriptome (10 × Genomics) further conducted. Among samples from 23 septic 10 healthy individuals,...
ADC189 is a novel anti-influenza virus inhibitor. In this study, we aimed to evaluated the safety and efficacy of in outpatients with uncomplicated influenza infection. phase 2 trial, assigned patients 2:2:1 ratio receive either single dose 15-mg or 45-mg placebo. 3 part, participants were randomized 2:1 The primary end point was time alleviation symptoms intention-to-treat infected population. trial that had 150 participants, median for RNA clearance shorter both groups (15-mg group,...