A5100346353- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Quantum Chromodynamics and Particle Interactions
- Long-Term Effects of COVID-19
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Vitamin C and Antioxidants Research
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Psoriasis: Treatment and Pathogenesis
- Intensive Care Unit Cognitive Disorders
- HIV/AIDS drug development and treatment
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Botulinum Toxin and Related Neurological Disorders
- High-Energy Particle Collisions Research
- Pneumocystis jirovecii pneumonia detection and treatment
Sichuan Academy of Traditional Chinese Medicine
2025
Tianjin Medical University General Hospital
2024-2025
Shenyang Aerospace University
2025
The University of Texas Health Science Center at Houston
2025
Wuhan University
2017-2024
Zhongnan Hospital of Wuhan University
2017-2024
University of Pittsburgh
2019-2024
Second Military Medical University
2012-2024
Hebei Medical University
2024
Changhai Hospital
2019-2024
Abstract Background Clinical findings indicated that a fraction of coronavirus disease 2019 (COVID-19) patients diagnosed as mild early may progress to severe cases. However, it is difficult distinguish these in the stage. The present study aimed describe clinical characteristics patients, analyze related factors, and explore predictive markers aggravation. Methods laboratory data nonsevere adult COVID-19 Changsha, China, were collected analyzed on admission. A logistic regression model was...
Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was COVID-19.
Introduction The rapid worldwide spread of COVID-19 has caused a global health crisis. To date, symptomatic supportive care been the most common treatment. It reported that mechanism is related to cytokine storms and subsequent immunogenic damage, especially damage endothelium alveolar membrane. Vitamin C (VC), also known as L-ascorbic acid, shown have antimicrobial immunomodulatory properties. A high dose intravenous VC (HIVC) was proven block several key components storms, HIVC showed...
Patients with coronavirus disease 2019 (COVID-19) exhibit a spectrum of respiratory symptoms like cough and dyspnea.1-3 Airway mucus is an adhesive viscoelastic gel composed mostly high-molecular-weight mucous glycoproteins water, which important in maintaining lung function health, pathological hypersecretion may cause airway obstruction lead to distress. Mucin (MUC) are the major macromolecular components mucus, classified into two types: gel-forming secreted MUC5AC membrane-tethered...
IL-35 downregulates Th17 cell development and suppresses certain types of autoimmune inflammation such as collagen-induced arthritis experimental uveitis. Psoriasis is thought to be initiated by abnormal interactions between cutaneous keratinocytes systemic immune cells. However, the role in psoriasis remains unclear. In this study, we assessed three well-known models: a human keratinocyte line (HaCaT), keratin 14 (K14)-vascular endothelial growth factor A (VEGF-A)-transgenic (Tg) mouse...
Sepsis-induced AKI (acute kidney injury) is considered an inflammation-related disease with high mortality. LPS-induced (Lipopolysaccharide) TLR4-NFκB pathway activation plays important role in sepsis-induced AKI. Pyroptosis closely associated inflammation response includes inflammasome formation, caspase1 and GSDMD N-terminal fragment cleavage that leads to cell membrane rupture death, which may be related the pathogenesis of MIF (Macrophage migration inhibitory factor), response, has been...
The pathological mechanism of sepsis-associated acute kidney injury (SA-AKI) is complex and involves tubular epithelial cell (TEC) death immune activation. However, the interaction between macrophage-mediated inflammation remains unclear. In this study, we uncovered that TEC ferroptosis was activated in SA-AKI. Increased levels ferroptotic markers, including ferroptosis-related proteins, lipid peroxidation, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), reactive oxygen species (ROS),...
Abstract Background Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge Salvia miltiorrhiza Bunge, respectively, both which have been employed in treatment cardiovascular diseases. Nevertheless, efficacy combination (Co) Ta-IIA As-IV for diseases remain unclear warrant further investigation. This study aimed to investigate underlying molecular mechanism Co treating myocardial...
The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) on psoriasis have been reported in rats, mice and humans, but the specific mechanisms involved not well defined. present study utilized fat-1 mouse, a transgenic model that can endogenously convert n-6 FAs into PUFAs, to directly determine if outcomes were correlated with PUFAs. Wild-type (WT) mice, which treated daily imiquimod (IMQ) cream or control shaved right ear dorsal skin, fed same diet. severity inflammation skin was...
Abstract Background The outbreak of a novel coronavirus since December 2019, became an emergency major international concern. As June 21, 2020, the SARS-CoV-2 pandemic has caused 8,769,844 confirmed infections with 463,745 fatal cases worldwide. is challenge for clinicians. In our clinic, we found rare case that COVID-19 patient combined ischemic stroke. Case presentation A 79-year-old man was admitted to Hubei Provincial Hospital Traditional Chinese Medicine due right limb weakness 1 day...
Background Thrombocytopenia has been proved to be associated with hospital mortality in patients severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. However, the detailed association of thrombocytopenia subsequent progression organ functions and long-term prognosis critically ill COVID-19 remains explored. Methods Medical records 167 confirmed cases from February 16 March 21, 2020 were collected this two-center retrospective study. 180-day’s outcome clinical development...
This study aimed to develop an algorithm using the explainable artificial intelligence (XAI) approaches for early prediction of mortality in intensive care unit (ICU) patients with acute kidney injury (AKI). gathered clinical data AKI from Medical Information Mart Intensive Care IV (MIMIC-IV) US between 2008 and 2019. All were further randomly divided into a training cohort validation cohort. Seven machine learning methods used models assessing in-hospital mortality. The optimal model was...
Sepsis is a systemic inflammatory state that occurs in response to infection and significantly increases mortality combination with acute kidney injury (AKI). Macrophages accumulate the after undergo transition from proinflammatory (M1) phenotype an alternatively activated (M2) required for normal repair. However, specific signals regulate M1 M2 vivo are unknown. Here, we found unexpected role of Colony stimulating factor 2 (Csf2) controlling macrophage vitro mouse model sepsis induced by...
Abstract Background Corticoid therapy has been recommended in the treatment of critically ill patients with COVID-19, yet its efficacy is currently still under evaluation. We investigated effect corticosteroid on 90-day mortality and SARS-CoV-2 RNA clearance severe COVID-19. Methods 294 COVID-19 were recruited between December 30, 2019 February 19, 2020. Logistic regression, Cox proportional-hazards model marginal structural modeling (MSM) applied to evaluate associations use corresponding...
Dysregulation of T cell apoptosis contributes to the pathogenesis acute systemic inflammation-induced immunosuppression, as seen in sepsis and trauma. However, regulatory mechanisms are unclear. Activation stimulator interferon genes (STING) has been shown induce apoptosis. Notch was previously identified top negative regulator STING macrophages through a kinase inhibitor library screening. how signaling regulates activation cells is unknown. Here, using γ-secretase block signaling, we found...
Septic patients requiring intensive care unit (ICU) readmission are at high risk of mortality, but research focusing on the association ICU due to sepsis and mortality is limited. The aim this study was develop validate a machine learning (ML) model for predicting in-hospital in septic readmitted using routinely available clinical data. data used were obtained from Medical Information Mart Intensive Care (MIMIC-IV, v1.0) database, between 2008 2019. cohort included with readmission. randomly...
The tissue inhibitor of metalloproteinases 2 (TIMP2) has emerged as a promising biomarker for predicting the risk sepsis-associated acute kidney injury (SA-AKI). However, its exact role in SA-AKI and underlying mechanism remains unclear. In this study, we investigated impact tubule-specific Timp2 knockout mice on inflammation. Our findings demonstrated that Timp2-knockout exhibited more severe than wild-type mice, along with elevated levels pyroptosis markers NOD-like receptor protein 3...
<b><i>Aims:</i></b> This study aims to evaluate the diagnostic capabilities of neuropathy symptom and change (NSC) score, impairment score (NIS) Michigan screening instrument (MNSI) in diagnosing diabetic peripheral (DPN). <b><i>Methods:</i></b> A total 131 patients with type II diabetes received NSC, NIS MNSI scoring systems. Electromyography/nerve conduction velocity (EMG/NCV) test was taken as gold standard. Correlations between EMG/NCV 3...