A5102000386- COVID-19 Clinical Research Studies
- Bone Metabolism and Diseases
- Advanced Proteomics Techniques and Applications
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Bone health and osteoporosis research
- Mass Spectrometry Techniques and Applications
- Bone health and treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Response and Inflammation
- S100 Proteins and Annexins
- Inflammasome and immune disorders
- Blood Coagulation and Thrombosis Mechanisms
- Liver Disease Diagnosis and Treatment
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- Pancreatitis Pathology and Treatment
- Proteoglycans and glycosaminoglycans research
- Heart Failure Treatment and Management
- Neonatal Respiratory Health Research
- Hemoglobin structure and function
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
Third People's Hospital of Hefei
2025
Anhui Medical University
2025
Huazhong University of Science and Technology
2013-2024
Union Hospital
2013-2024
Fudan University
2023
Union Hospital
2017-2022
Jiangsu University of Science and Technology
2022
Wenzhou Medical University
2017-2021
Texas Tech University
2014-2020
Zhongnan Hospital of Wuhan University
2015-2020
Background and Aims In December 2019, an outbreak of coronavirus disease 2019 (COVID‐19) emerged in Wuhan, China. Although it has been reported that some patients with COVID‐19 showed elevated liver biochemistries, there are few studies regarding the clinical features prognosis these patients. Approach Results this multicenter, retrospective study, we collected data on laboratory‐confirmed from three hospitals China, who died or were discharged between February 1, 2020, 20, 2020. Data...
Highlights•The COVID-19 patients with CVD experienced more severe pneumonia.•The showed tissue injury-related enzymes release.•The were at higher risk of cytokine storm.•The hypercoagulable state.•CVD is a factor for the progression and prognosis COVID-19.AbstractBackground aimA novel coronavirus acute respiratory syndrome corona virus 2 (SARS-CoV-2) caused pneumonia, Coronavirus Disease 2019 (COVID-19), broke out in Wuhan, China December 2019, spread all over world. Patients huge...
Abstract Background Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge Salvia miltiorrhiza Bunge, respectively, both which have been employed in treatment cardiovascular diseases. Nevertheless, efficacy combination (Co) Ta-IIA As-IV for diseases remain unclear warrant further investigation. This study aimed to investigate underlying molecular mechanism Co treating myocardial...
Associating changes in protein levels with the onset of cancer has been widely investigated to identify clinically relevant diagnostic biomarkers. In present study, we analyzed sera from 205 patients recruited United States and Egypt for biomarker discovery using label-free proteomic analysis by LC-MS/MS. We performed untargeted candidate proteins statistically significant differences between hepatocellular carcinoma (HCC) liver cirrhosis. further evaluated significance 101 same through...
Epithelial-mesenchymal transition (EMT), characterized by the decrease of E-cadherin (E-Cad) and increase in vimentin alpha-smooth muscle actin (α-SMA), was demonstrated to participate inflammatory bowel disease-related fibrosis. miR-200b plays an anti-fibrosis role inhibiting EMT targeting ZEB1 ZEB2. But stability exogenous blood limits its application. Microvesicles (MVs), which can transfer miRNAs among cells prevent them from degradation, may provide excellent transport system for...
Objective Abnormal liver function is a common form of extra‐pulmonary organ damage in patients with coronavirus disease 2019 (COVID‐19). Patients severe COVID‐19 have higher probability and progression injury than those without disease. We aimed to evaluate the prognosis COVID‐19. Methods retrospectively included 502 laboratory‐confirmed SARS‐CoV‐2 infection. Clinical features survival were compared. Cox proportional hazards models used determine variables that might an effect on survival....
Abstract Breast cancer brain metastasis has been recognized as one of the central issues in breast research. The elucidation processes and pathways that mediate this step will provide important clues for a better understanding metastasis. Increasing evidence suggests aberrant glycosylation patterns greatly contribute to cell invasion Herein, we combined next-generation RNA sequencing with liquid chromatography-tandem mass spectrometry-based proteomic N-glycomic analysis from five lines line...
Background and Aim: Liver test abnormalities are common in COVID-19 patients. The aim of our study was to determine risk factors for different liver injury patterns evaluate the relationship between prognosis patients with COVID-19. Methods: We retrospectively analyzed admitted January 1st March 10th, laboratory-confirmed followed them up April 20th, 2020. Information clinical features collected analysis. Results: As a result, total 838 hospitalized confirmed COVID-19, including 48.8%...
Background: Last winter, a new coronavirus-induced pneumonia, COVID-19, broke out in Wuhan, China, and spread rapidly throughout the country due to its high infectivity. Although several researches on clinical characteristics have been published, indicators dynamic changes during disease progression are still not clear need be further explored.Methods: We retrospectively studied 165 patients with COVID-19 who were admitted five hospitals outside Wuhan from January 2 February 5, 2020....
The incidence of minor ischemic stroke (MIS) and associated cognitive impairment is rising, particularly among younger individuals. Thus, both primary secondary prevention strategies are essential. This study investigated the risk factors for cerebral artery stenosis (CAS) in patients with MIS classified as large atherosclerosis (LAA) by TOAST, examined relationship between function plasma lipoprotein-associated phospholipase A2 levels. We conducted a retrospective analysis 789 admitted to...
Interleukin 18 (IL–18) is a pro-atherogenic cytokine associated with the occurrence of various cardiac complications. The IL–18 gene has functional −137 G/C polymorphism (rs187238) in promoter region. Using ligase detection reaction-polymerase chain reaction, we genotyped cohort patients Chinese Han population Xiangfan Case coronary artery disease and control were identified by angiography. plasma concentrations measured ELISA. A significant increase G allele or GG-genotype was observed 241...
Vascular smooth muscle cells (VSMCs) are known to undergo functional changes that contribute the pathogenesis of atherosclerosis and restenosis. Wnts a family secreted glycoproteins bind transmembrane Frizzled receptors initiate signaling cascades with indispensable roles during cell migration, adhesion, proliferation, survival. The present study reports wingless-type MMTV integration site family, member 3a (Wnt3a) activates canonical Wnt pathway in rat VSMCs by triggering phosphorylation...
To study the correlations of lymphocytes and cytokines between changes lung lesion volumes in patients with COVID-19, to predict these correlations.
Abstract Early detection is a key step for effective intervention of hepatocellular carcinoma (HCC), the lack sensitive and specific biomarkers major reason high rate HCC‐related mortality. This report described an integrated strategy by combining SELDI‐ProteinChip, sophisticated algorithm analysis, acetonitrile (ACN) pre‐treatment two‐dimensional electrophoresis (2DE)–peptide mass fingerprinting (PMF) techniques to identify serological markers prediction HBV‐related HCC. Proteomic profiling...
Abstract Breast cancer is the leading type of in women. brain metastasis currently considered an issue concern among breast patients. Membrane proteins play important roles metastasis, involving cell adhesion and penetration blood–brain barrier. To understand mechanism liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) was employed conjunction with enrichment membrane to analyze proteomes from five different a lines. Quantitative proteomic data all lines were compared MDA‐MB‐231BR...
Purpose/Objective Prompted by preliminary findings, this study was conducted to investigate the impact of zoledronic acid on cancellous bone microstructure and its effect level β-catenin in a mouse model postmenopausal osteoporosis. Methods Materials 96 8-week-old specific-pathogen-free C57BL/6 mice were randomly divided into 4 groups (24 per group): sham group, an ovariectomized osteoporosis estradiol-treated acid-treated group. Five months after surgery, third lumbar vertebra left femur...
As populations age, the number of patients sustaining traumatic brain injury (TBI) and concomitantly receiving preinjury antiplatelet therapy such as aspirin (ASA) clopidogrel (CLOP) is rising. These drugs have been linked with unfavorable clinical outcomes following TBI, where exact mechanism(s) involved are still unknown. In this novel work, we aimed to identify compare altered proteome profile imposed by ASA CLOP when administered alone or in combination, prior experimental TBI....