A5024256842- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- Dermatological and COVID-19 studies
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Respiratory Support and Mechanisms
- Circular RNAs in diseases
- Asthma and respiratory diseases
- Gastric Cancer Management and Outcomes
- Antifungal resistance and susceptibility
- Nitric Oxide and Endothelin Effects
- NF-κB Signaling Pathways
- Organic Chemistry Cycloaddition Reactions
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
Nanjing University
2024
Hunan University of Traditional Chinese Medicine
2024
Wenzhou Medical University
2017-2023
Zhejiang Taizhou Hospital
2017-2021
The number of patients with pneumonia stemming from the 2019 novel coronavirus (COVID-19) infection has increased rapidly. However, clinical characteristics discharged remain little known. Here, we attempt to describe and treatment experiences cases Taizhou, China.A total 60 COVID-19-infected who were Taizhou Enze Medical Center (Group), January 31, 2020, February 16, included in analysis. discharge criteria based on New Coronavirus Pneumonia Prevention Control Program (Fifth Edition,...
This study explored the relationship between fractional exhaled nitric oxide (FeNO) level and efficacy of inhaled corticosteroid (ICS) in asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) patients with different severity.A total 127 ACOS (case group) 131 healthy people (control were enrolled this study.Based on severity COPD, divided into: mild ACOS; moderate severe extremely groups.We compared FeNO levels, function parameters including percentage forced expiratory...
A case report of coinfection with Talaromyces marneffei (T. marneffei) and Cryptococcus neoformans (C. neoformans) is presented in a 57‑year‑old woman hemolytic anemia who received dexamethasone for 8 years. To the best our knowledge, this patient was successfully treated voriconazole. This first T. C. HIV‑negative host. Clinicians should be aware concomitant infection other pathogens immunocompromised hosts. The current highlights importance clinician awareness concurrent infections...
To study the correlations of lymphocytes and cytokines between changes lung lesion volumes in patients with COVID-19, to predict these correlations.
Novel coronavirus disease 2019 (COVID-19) was discovered in December and has infected more than 80 million people worldwide, 50 have achieved a clinical cure. In this study, the pulmonary function results of patients after medicine for three months were reported.To investigate effect COVID-19 on lung patients.A retrospective analysis performed 56 COVID-19-infected who cured treatment at Taizhou Public Health Medical Center Zhejiang Province from January 31, 2020, to March 10, 2020. At...
Abstract Accumulating evidences revealed that long noncoding RNAs (lncRNAs) are frequently implicated in non‐small cell lung cancer (NSCLC). Herein, we reported the identification of a novel NSCLC‐associated functional lncRNA ZNF205 antisense RNA 1 (ZNF205‐AS1). ZNF205‐AS1 was increased NSCLC tissues and lines, associated with poor prognosis patients. Bioinformatics prediction, combined experimental verification early growth response 4 (EGR4) directly bound to promoter, promoter activity ,...
The present study aimed to investigate the association between expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) long non‑coding RNA (lncRNA) and recurrence non‑small cell cancer (NSCLC) elucidate potential mechanisms MALAT1 in vitro. Between June 1, 2010 December 30, 2016, NSCLC tumor tissues adjacent non‑cancerous were obtained from 120 patients with NSCLC, who had undergone surgical resection at Taizhou Hospital Wenzhou Medical University (Linhai, China). total...
Abstract EGFR inhibitors have revolutionized the treatment of advanced non-small-cell lung cancer (NSCLC). Mefatinib is a novel, bioavailable, second-generation, irreversible pan- inhibitor. This phase Ib/II open-label, single-arm, multi-center study investigated efficacy, safety, biomarker, and resistance mechanisms mefatinib in first-line patients with -mutant NSCLC. included 106 stage IIIB-IV NSCLC who received at daily dose either 60 mg ( n = 51) or 80 55). The primary endpoint was...
Background Interleukin-18 (IL-18), or interferon (IFN)-γ-inducing factor, potentiates T helper 1 and natural killer cell activation as well CD8 + T-cell proliferation. Recombinant IL-18 has displayed limited clinical efficacy in part due to the expression of decoy receptor, binding protein (IL-18BP). A series variants that are devoid IL-18BP binding, termed DR18 (decoy-resistant IL-18), was developed via directed evolution. We tested using oncolytic adenovirus (oAd) a platform for delivery...
Immune-related adverse reactions primarily involve the skin and endocrine, digestive, respiratory systems. In endocrine system, these effects mainly include hypophysitis, thyroiditis, hypoadrenalism, rarely, diabetes mellitus. The most common symptoms in are pruritus, rash, infrequently, eruptive keratoacanthoma. Here, we report a case of 67-year-old woman who developed keratoacanthoma 6 weeks after beginning treatment with bispecific antibody (PM8001), targeting both programmed cell death...
Third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) show good selectivity for classical EGFR mutated and T790M non-small cell lung cancer (NSCLC). However, resistance inevitably occurs to third-generation EGFR-TKI. This study describes the real-world characteristics, efficacy, safety of treating post-progression NSCLC with 160 mg furmonertinib (in combination or without anti-angiogenic agents chemotherapy) EGFR-TKIs.EGFR-mutated patients intracranial...
The imbalance between the proliferation and apoptosis of pulmonary artery smooth muscle cells (PASMCs) is importance in vascular remodeling. Shikonin, a naphthoquinone compound extracted from Chinese medicinal herb Lithospermum erythrorhizon, inhibits rat (SMCs). present study was designed to investigate effects shikonin on PASMCs possible mechanisms involved. Rat were cultured under following five treatment conditions: Normal control; hypoxia for 24 h; + 1 µM 2 4 h. viability measured using...
PD-L1 is one of the current biomarkers for immune checkpoint inhibitor (ICI) therapy in patients with non-small-cell lung cancer. However, expression real world and its related influencing factors remain unclear. We want to observe study through collection analysis clinical data. R software (version 4.0) was used perform data “corplot” package correlation analysis. A total 296 individuals (mean [SD] age, 67 [9] years; 23%female) were assessed. According amount PD-L1, cohort divided into low...
Repeatedly hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are often exposed to more antibiotics, but the distribution pathogenic bacteria in these is poorly understood. The objectives this study were analyze and risk factors associated multidrug-resistant (MDR) infection early re-admission AECOPD.We retrospectively reviewed charts for AECOPD admitted our hospital between January 2011 November 2012. group non-early readmission determined by...
Objective To investigate the relationship between post-traumatic growth, morbidity stigma and readiness for discharge in post-operative thyroid cancer patients. Methods 422 patients from three tertiary care hospitals Hunan Tianjin were surveyed using General Information Questionnaire, Post-traumatic Growth Scale, Readiness Discharge Social Influence Scale. Results positively predicted level of growth (P < 0.01), negatively with playing a mediated role growth. Conclusions can predict...
Progressive acute respiratory distress syndrome (ARDS) is the most lethal cause in patients with severe COVID-19 pneumonia due to uncontrolled inflammatory reaction, for which we found that early intervention of combined treatment methylprednisolone and human immunoglobulin a highly effective therapy improve prognosis COVID-19-induced patients. Objective. Herein, have demonstrated clinical manifestations, laboratory, radiological characteristics Coronavirus Disease-2019 (COVID-19) pneumonia,...
Background: In December 2019, the first case of pneumonia associated with 2019 novel coronavirus was found in Wuhan and rapidly spread throughout China, so data are needed on clinical characteristics affected patients. Methods: Cases COVID-19 infection confirmed by laboratory four hospitals Taizhou city from January 17, 2020 to February 26, were collected divided into non-severe group severe according severity disease. The manifestations, examinations imaging features two groups analyzed,...
Abstract Background: In December 2019, the first case of pneumonia associated with SARS-CoV-2 was found in Wuhan and rapidly spread throughout China, so data are needed on affected patients. The purpose our study to find clinical manifestations CT features COVID-19. Methods: All patients COVID-19 Taizhou city were retrospectively included divided into non-severe group severe according severity disease. manifestations, laboratory examinations imaging analyzed, differences between two groups...
Abstract Background Almonertinib is an oral third-generation tyrosine kinase inhibitor (TKI) targeting the epidermal growth factor receptor (EGFR). It has exhibited substantial antitumor efficacy and well-tolerated toxicity in prior clinical investigations. This study investigated non-inferiority of almonertinib compared to osimertinib patients with advanced EGFR-positive non-small cell lung cancer (NSCLC). Method In this retrospective analysis, NSCLC, experiencing progression after...
Background: The outbreak of COVID-19 has a significant impact on the health people around world. In clinical condition COVID-19, critical cases changes rapidly with high mortality rate. Therefore, early prediction disease severity and active intervention play an important role in prognosis severe patients. Methods: All patients Taizhou city were retrospectively included segregated into non-severe group according to disease. manifestations, laboratory examination results, imaging findings 2...