A5043564906- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Cardiac tumors and thrombi
- Lung Cancer Diagnosis and Treatment
- Melanoma and MAPK Pathways
- Vascular Tumors and Angiosarcomas
- Lung Cancer Research Studies
- Immune Cell Function and Interaction
- Bioinformatics and Genomic Networks
- CAR-T cell therapy research
- Cutaneous Melanoma Detection and Management
- Cancer-related molecular mechanisms research
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Myofascial pain diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical and Thoracic Myelopathy
- Cutaneous lymphoproliferative disorders research
- Metastasis and carcinoma case studies
- Veterinary medicine and infectious diseases
Zhejiang University
2020-2024
Fudan University Shanghai Cancer Center
2018-2024
Shanghai Medical College of Fudan University
2018-2024
Gansu Provincial Hospital
2020-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2021
Tianjin Medical University
2021
Purpose: Our study aimed to describe the clinical features of undifferentiated pleomorphic sarcoma (UPS) and identify predictors poor outcomes. Patients methods: The clinicopathological variables treatment strategies 100 UPS patients who underwent surgical resections at a single institution between November 2004 July 2016 were reviewed. Kaplan–Meier Cox regression method conducted for survival analysis. Results: median follow-up time was 94 months (range, 1.5–154 months). R0 resection...
This study seeks to enhance the accuracy and efficiency of clinical diagnosis therapeutic decision-making in hepatocellular carcinoma (HCC), as well optimize assessment immunotherapy response.
Lung adenocarcinoma (LUAD) is often diagnosed at an advanced stage, so it necessary to identify potential biomarkers for the early diagnosis and prognosis of LUAD. In our study, a gene co-expression network was constructed using weighted analysis (WGCNA) in order obtain key modules genes correlated with LUAD prognosis. Four hub (HLF, CHRDL1, SELENBP1, TMEM163) were screened out least absolute shrinkage selection operator (LASSO)-Cox regression analysis; then, prognostic model established...
Abstract Background To construct a predictive model of immunotherapy efficacy for patients with lung squamous cell carcinoma (LUSC) based on the degree tumor-infiltrating immune cells (TIIC) in tumor microenvironment (TME). Methods The data 501 LUSC TCGA database were used as training set, and grouped using non-negative matrix factorization (NMF) TIIC assessed by single-sample gene set enrichment analysis (GSEA). Two sets (GSE126044 GSE135222) validation sets. Genes screened modeling least...
Background: To describe the clinical features of retroperitoneal dedifferentiated liposarcoma (RP DDLS) and further evaluate prognostic factors. Methods: The clinicopathological variables treatment strategies 61 RP DDLS patients who underwent surgical resections at a single institution between September 2005 2016 were reviewed. Kaplan-Meier Cox regression methods conducted for survival analyses. Results: average patients' age was 52 years (range, 27-81), there almost no gender predilection...
This study was conducted in order to establish a long non-coding RNA (lncRNA)-based model for predicting overall survival (OS) patients with lung adenocarcinoma (LUAD).Original RNA-seq data of LUAD samples were extracted from The Cancer Genome Atlas (TCGA) database. Univariate Cox analysis performed select lncRNAs associated OS. least absolute shrinkage and selection operator (LASSO) regression multivariate building an OS-associated lncRNA prognostic model. Moreover, receiver operating...
Skin cutaneous melanoma (SCM) is a common malignant tumor of the skin and its pathogenesis still needs to be studied. In this work, we constructed co-expression network screened for hub genes by weighted gene analysis (WGCNA) using GSE98394 dataset. The relationship between mRNA expression prognosis patients with was validated Gene Expression Profiling Interactive Analysis (GEPIA) database. Furthermore, immunohistochemistry in Human Protein Atlas used validate grayscale performed ImageJ...
Abstract EGFR inhibitors have revolutionized the treatment of advanced non-small-cell lung cancer (NSCLC). Mefatinib is a novel, bioavailable, second-generation, irreversible pan- inhibitor. This phase Ib/II open-label, single-arm, multi-center study investigated efficacy, safety, biomarker, and resistance mechanisms mefatinib in first-line patients with -mutant NSCLC. included 106 stage IIIB-IV NSCLC who received at daily dose either 60 mg ( n = 51) or 80 55). The primary endpoint was...
Background: Observing and studying clinical efficacy safety of apatinib mesylate tablet in the treatment advanced malignant melanoma (MM). Methods: Retrospectively analyzing data 22 patients with metastatic MM who had failed conventional chemotherapy from June 2016 to January 2018. All took 500 mg tablets per day. The should be evaluated according RECIST 1.1 criteria. Adverse events (AEs) graded NCI-CTCAE 4.0. Results: There were two cases partial remission (PR), 11 stable disease (SD) nine...
The aim of this study was to evaluate the prognostic value pretreatment inflammatory biomarkers in retroperitoneal liposarcoma (RPLS) patients after radical resection.One hundred with RPLS who underwent resection between September 2004 and October 2010 at Fudan University Shanghai Cancer Center were included study. Laboratory tests peripheral blood sampled before surgery. optimal cutoff values systemic markers defined by receiver-operating curve analyses. Curves disease-free survival (DFS)...
The objective of this retrospective study was to evaluate the prognostic value various factors in clear cell sarcoma patients after radical surgery. Forty-two from August 2006 March 2018 were included study. Curves disease-free survival and overall calculated using Kaplan–Meier method, univariate multivariate analyses performed a Cox proportional hazard regression model. Laboratory test peripheral blood recorded before optimal cutoff systemic inflammatory markers defined by...
The present study aimed to explore the prognostic value, function, and mechanism of CCNDBP1 in dedifferentiated liposarcoma (DDL). Immunohistochemistry staining was used analyze protein expression tissue specimens. After silencing LPS853 overexpressing LPS510, CCK-8, clone formation, transwell migration, invasion assays were detect cell proliferation, ability. CCNDBP1-induced apoptosis analyzed by flow cytometry. altered epithelial-mesenchymal transition (EMT)-related proteins detected...
Background: The clinical efficacy and safety of Endostar combined with chemotherapy in the treatment metastatic malignant melanoma (MM) were analyzed indicators capable predicting regimen identified to guide practice. Patients methods: data 55 patients MM without gene mutations who treated dacarbazine cisplatin retrospectively analyzed. Efficacy was assessed using RECIST 1.1, adverse events (AEs) graded according NCI-CTCAE 4.0. log-rank test used compare survival curves different subgroups,...
Abstract Background: Among all types of cervical spondylitis, spondylitis radiculopathy (CSR) has the highest incidence. The incidence CSR increases year by and is generally younger, which seriously threatened people's quality life affected their work life. This study proposes to improve recovery rate patients with CSR, delay recurrence, symptoms patients, through rehabilitation exercise five-step vertebra exercises. Methods: For 90 that met inclusion criteria, SPSS 23.0 software random...
11562 Background: High-grade soft tissue sarcomas (STS) pose a therapeutic challenge due to the high risk of recurrence, even following complete resection. Anlotinib is multi-targeted tyrosine kinase inhibitor blocking angiogenesis pathways VEGFR, FGFR, and PDGFR. Given promising efficacy for treating patients with unresectable advanced STS in previous trials, we evaluated role anlotinib as adjuvant therapy completely resected high-grade STS. Methods: In single-center, double-blinded,...
Background This study aimed to establish a comprehensive clinical prognostic risk model based on pulmonary function tests. was intended guide the evaluation and predictive management of patients with resectable stage I-III non-small cell lung cancer (NSCLC) receiving neoadjuvant chemoimmunotherapy. Methods Clinical pathological characteristics survival data for 175 were collected. Univariate multivariate Cox regression analyses, least absolute shrinkage selection operator (LASSO) analysis...
e21557 Background: Patients with completely resected stage III melanoma are under high risk of disease recurrence. Recurrence-free survival (RFS) remains unsatisfactory despite there is adjuvant anti-PD-1 monotherapy following surgery, the 1-year RFS about 70% and 2-year 49% in our country. It's urgent to explore combined regimens further improve RFS. Here we report interim efficacy safety results toripalimab (a PD-1 inhibitor) plus recombinant human endostatin (an angiogenesis as therapy...
Biopsy with full histopathological information for melanoma is strongly recommended in the era of target and immunotherapy. Fine needle aspiration cytology (FNAC) primary regional lymph nodes has been implied making a decision resection repair. The purpose this study was to investigate accuracy safety FNAC Chinese patients acral cutaneous melanoma, evaluate influencing factors its impact on prognosis. Data 128 stage 0-III who were treated Fudan University Shanghai Cancer Center from 2009...
Objective: Most patients with advanced lung cancer have a poor prognosis. Recent studies identified TRIM59 as novel molecule that serves prognostic factor for the progression of non-small cell cancer. In present study, we investigated role in predicting prognosis adenocarcinoma (LUAD) well correlation between expression and immune infiltrates. Methods: We analyzed normal tumor tissues based on RNA-sequencing datasets from The Cancer Genome Atlas Genotype-Tissue Expression databases....