A5102884399- Sarcoma Diagnosis and Treatment
- Management of metastatic bone disease
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Bone Tumor Diagnosis and Treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Bone health and treatments
- Surgical site infection prevention
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Medical Imaging and Analysis
- Vascular Tumors and Angiosarcomas
- Wnt/β-catenin signaling in development and cancer
- Microtubule and mitosis dynamics
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Lung Cancer Treatments and Mutations
- Zebrafish Biomedical Research Applications
- Glioma Diagnosis and Treatment
Fudan University Shanghai Cancer Center
2014-2025
Shanghai Medical College of Fudan University
2019-2025
Massachusetts General Hospital
2022-2024
Harvard University
2023
East China Normal University
2021
Shanghai Changzheng Hospital
2021
Shanghai University of Traditional Chinese Medicine
2021
Second Military Medical University
2015-2017
Zhejiang University
2011
Abstract Purpose: We aimed to investigate the efficacy and safety of anlotinib as adjuvant targeted therapy for completely resected localized high-grade soft-tissue sarcomas (STS). Patients Methods: with STS after complete resection were randomly assigned in a 1:1 ratio receive either oral 12 mg or placebo once daily on days 1 14 every 21 cycle, up six cycles until disease relapse, unmanageable toxicity, death. The analyzed. This trial was first exploring (NCT03951571). Results: Between June...
Background/Aims: There have been many studies on the etiology of osteoarthritis (OA) with regard to function inflammatory cytokines, process cartilage degradation, miR-146a, hypoxia stimulation and autophagy in OA chondrocytes, but there no reports relationship between miR-146a cartilage, especially under hypoxia. This study aimed confirm Methods: Chondrocytes were treated by gradients, main factors including HIF-1α, HIF-2α, Bcl-2 markers ULK-1, ATG-5 detected quantitative PCR (Q-PCR)...
Purpose: Our study aimed to describe the clinical features of undifferentiated pleomorphic sarcoma (UPS) and identify predictors poor outcomes. Patients methods: The clinicopathological variables treatment strategies 100 UPS patients who underwent surgical resections at a single institution between November 2004 July 2016 were reviewed. Kaplan–Meier Cox regression method conducted for survival analysis. Results: median follow-up time was 94 months (range, 1.5–154 months). R0 resection...
The treatment of malignant bone tumors by chemotherapeutics often receives poor therapeutic response due to the specific physiological environment, and thus calls for development new options. Here, we reported a bone-targeted protein nanomedicine this purpose. Saporin, toxin protein, was co-assembled with boronated polymer intracellular delivery, formed nanoparticles were further coated an anionic poly (aspartic acid) shield positive charges on provide targeting function. prepared ternary...
Abstract Bone metastasis is of common occurrence in renal cell carcinoma with poor prognosis, but no optimal treatment approach has been established for bone metastatic carcinoma. To explore the potential therapeutic targets carcinoma, we profile single transcriptomes 6 primary and 9 We also include scRNA-seq data early-stage late-stage normal kidneys healthy marrow samples study to better understand niche. The molecular properties dynamic changes major lineages environment are...
The present study was designed to explore the underlying role of hypoxia-inducible factor 1α (HIF-1α) in reactive oxygen species (ROS) formation and apoptosis osteosarcoma (OS) cells induced by hypoxia.In OS cells, ROS accumulated increased within 24 h after exposure low HIF-1α expression levels. A co-expression analysis showed that HIF positively correlated with Forkhead box class O1 (FoxO1) negatively CYP-related genes from National Center for Biotechnology Information's Gene Expression...
<div>AbstractPurpose:<p>We aimed to investigate the efficacy and safety of anlotinib as adjuvant targeted therapy for completely resected localized high-grade soft-tissue sarcomas (STS).</p>Patients Methods:<p>Patients with STS after complete resection were randomly assigned in a 1:1 ratio receive either oral 12 mg or placebo once daily on days 1 14 every 21 cycle, up six cycles until disease relapse, unmanageable toxicity, death. The analyzed. This trial was first...
<p>Supplementary Figure S1. Kaplan-Meier Curve showing the 1-year real-world recurrence-free survival (rwRFS) rate in UPS patients with and without adjuvant anlotinib therapy.</p>
To investigate the clinical efficacy and safety of 3D printed artificial vertebral body for patients who underwent multilevel total en bloc spondylectomy (TES) analyze whether it could reduce incidence implant subsidence. This is a retrospective study. From January 2017 to May 2018, eight consecutive cases with spine tumor undergoing TES were analyzed. All X-ray CT examinations evaluate stability internal fixation during postoperative follow-up. Demographic, surgical details, data,...
Osteosarcoma (OS), a primary bone malignancy, is characterized by high rate of metastasis. It has been found that Sushi repeat containing protein X-linked 2 (SRPX2) involved in tumor cell proliferation, adhesion, invasion and migration. The current work aimed to explore the effect SRPX2 on OS proliferation.Immunohistochemistry (IHC), Western blotting reverse transcription-polymerase chain reaction (RT-PCR) were used detect expression associated tissues lines. Cell counting kit-8 (CCK8),...
Objectives: As diagnosis and treatment guidelines for bone sarcomas continue updating, it is important to examine whether, when, which kinds of patients have had a survival improvement over the last four decades. Methods: This cohort study included 9178 with primary joint from 1 January 1980 31 December 2018 using data Surveillance, Epidemiology End Results (SEER)-9 Registries. The follow-up period was extended November 2020. Patients were divided by decade into time periods: 1980–1989,...
Aims Socioeconomic and racial disparities have been recognized as impacting the care of patients with cancer, however there are a lack data examining impact these on bone sarcoma. The purpose this study was to examine socioeconomic that oncological outcomes Methods We reviewed 4,739 diagnosed primary sarcomas from Surveillance, Epidemiology End Results (SEER) registry between 2007 2015. examined race insurance status associated presence metastatic disease at diagnosis, treatment outcome,...
Lung cancer is the most common cause of death worldwide. The poor survival rate largely due to extensive local invasion and metastasis. However, mechanisms underlying metastasis lung cells remain elusive. In this study, we examined role preferentially expressed antigen melanoma (PRAME) in Our results show that PRAME downregulated adenocarcinoma bone compared with normal human lung. Knockdown decreases expression E-Cadherin promotes proliferation, invasion, by regulating multiple critical...
Abstract It has been reported that the proteasome activator REG γ is associated with multiple oncogenic pathways in human cancers. However, role of development melanoma and underlying mechanisms remain unclear. In this study, we attempted to investigate effects on cell proliferation vitro vivo. We demonstrated knockdown inhibited growth arrested at G1 phase. Furthermore, depletion also xenograft melanoma. Mechanistically, activates Wnt/β‐catenin signal pathway by degrading GSK ‐3β lines...
Liver damage is a dynamic process, and evaluation of liver injury degree the key step in disease diagnosis. However, few common markers among different types have been reported. Herein, we generated three mouse models, including Con A-induced, CCl4-injected, subjected bile duct ligation to simulate humans then performed label-free mass spectrometry identify differentially expressed proteins tissues. Interestingly, two proteins, G3BP ABCC6, were conserved regulated models are proposed be...