A5101708217- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Wnt/β-catenin signaling in development and cancer
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cytokine Signaling Pathways and Interactions
- Microtubule and mitosis dynamics
- TGF-β signaling in diseases
- Telomeres, Telomerase, and Senescence
- interferon and immune responses
- FOXO transcription factor regulation
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- Dendrimers and Hyperbranched Polymers
- Synthesis and Characterization of Heterocyclic Compounds
- Thyroid Cancer Diagnosis and Treatment
- Bioactive natural compounds
- Immunotherapy and Immune Responses
- Clusterin in disease pathology
- Andrographolide Research and Applications
- Fibroblast Growth Factor Research
East China Normal University
2010-2019
Here we report that mice deficient for the proteasome activator, REGγ, exhibit a marked resistance to TPA (12-O-tetradecanoyl-phorbol-13-acetate)-induced keratinocyte proliferation, epidermal hyperplasia and onset of papillomas compared with wild-type counterparts. Interestingly, massive increase REGγ in skin tissues or cells resulting from induces activation p38 mitogen-activated protein kinase (MAPK/p38). Blocking MAPK prevents elevation HaCaT treatment. AP-1, downstream effector MAPK/p38,...
Our recent studies suggest a role for the proteasome activator REG (11S regulatory particles, 28-kDa activator)γ in regulation of tumor protein 53 (p53). However, molecular details and vivo biological significance REGγ-p53 interplay remain elusive. Here, we demonstrate that REGγ-deficient mice develop premature aging phenotypes are associated with abnormal accumulation casein kinase (CK) 1δ p53. Antibody array analysis led us to identify CK1δ as direct target REGγ. Silencing or inhibition...
Abstract Increasing incidence of inflammatory bowel disorders demands a better understanding the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextran sodium sulfate model. Bone marrow transplantation experiments suggest REGγ’s function non-haematopoietic cells primarily contributes to phenotype. Elevated expression...
The proteasome activator REGγ mediates a shortcut for the destruction of intact mammalian proteins. biological roles and underlying mechanisms are not fully understood. Here we provide evidence that regulates cellular distribution p53 by facilitating its multiple monoubiquitylation subsequent nuclear export degradation. We also show inhibition tetramerization might further enhance cytoplasmic relocation reduce active in nucleus. Furthermore, enhances physical interaction with HDM2 probably...
Forkhead box D3 (FOXD3), as a transcriptional repressor, is well known to be involved in the regulation of development. Although FoxD3 associated with several cancers, its role colon cancer and underlying mechanism are still unclear. Here, we first showed that FOXD3 knockdown dramatically increased proliferation human cells, enhanced cell invasive ability inhibited apoptosis. In vivo xenograft studies confirmed FOXD3-knockdown cells were more tumorigenic than controls. Silencing markedly...
Anaplastic thyroid cancer (ATC) is the most aggressive human malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator highly expressed in ATC, an important regulator of differentiation cells. Ablation REGγ significantly restored expression thyroid-specific genes, enhanced iodine uptake, improved efficacy 131I therapy xenograft models....
Abstract It has been reported that the proteasome activator REG γ is associated with multiple oncogenic pathways in human cancers. However, role of development melanoma and underlying mechanisms remain unclear. In this study, we attempted to investigate effects on cell proliferation vitro vivo. We demonstrated knockdown inhibited growth arrested at G1 phase. Furthermore, depletion also xenograft melanoma. Mechanistically, activates Wnt/β‐catenin signal pathway by degrading GSK ‐3β lines...
// Quan Huang 1, 2, * , Lei Li Lin Hui Chen 2 Yongyan Dang Jishen Zhang 1 Naimin Shao Hong Chang Zhengjie Zhou Chongyi Liu Bingwei He Haifeng Wei Jianru Xiao Department of Orthopedic Oncology, Changzheng Hospital, The Second Military Medical University, Shanghai, PR China Shanghai Key Laboratory Regulatory Biology, School Life Sciences, East Normal These authors have contributed equally to this work Correspondence to: Xiao, email: jianru_xiao12345@163.com Wei, haifeng_wei123@163.com...
p21Waf/Cip1, p16INK4a and p14ARF (p19ARF in mice) have been demonstrated to be degraded by REGγ-proteasome pathway an ATP- ubiquitin-independent manner vitro. However, the vivo roles of REGγ mediated-degradation remain unclear. In this study, we showed enhanced expression p19ARF multiple tissues from REGg–/– mice compared REGg+/+ mice. Furthermore, examined different cancer observed that protein levels were highly expressed human cancers while level appears inversely correlated. These...