A5059026866- Melanoma and MAPK Pathways
- Ubiquitin and proteasome pathways
- Protein Kinase Regulation and GTPase Signaling
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cytokine Signaling Pathways and Interactions
- Prostate Cancer Treatment and Research
- HER2/EGFR in Cancer Research
- 14-3-3 protein interactions
- Peptidase Inhibition and Analysis
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- RNA modifications and cancer
- Inflammatory mediators and NSAID effects
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Protein Tyrosine Phosphatases
- Mechanisms of cancer metastasis
Wright State University
2016-2025
Tulane University
2002-2023
Baylor College of Medicine
2007-2018
Air Force Medical University
2015
Abstract ERBB4/HER4 (referred to here as ERBB4) is a unique member of the epidermal growth factor receptor (EGFR) family tyrosine kinases. In contrast other three members EGFR (i.e., EGFR, ERBB2/HER2/NEU, and ERBB3), which are associated with aggressive forms human cancers, ERBB4 expression seems be selectively lost in tumors phenotypes. Consistent this observation, we show that induces apoptosis when reintroduced into breast cancer cell lines or endogenous activated by ligand. We further...
In contrast to the well-studied classic MAPKs, such as ERK1/2, little is known concerning regulation and substrates of atypical MAPK ERK3 signaling cascade its function in cancer progression. Here, we report that interacted with phosphorylated steroid receptor coactivator 3 (SRC-3), an oncogenic protein overexpressed multiple human cancers at serine 857 (S857). This ERK3-mediated phosphorylation S857 was essential for interaction SRC-3 ETS transcription factor PEA3, which promotes...
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival supports the anabolic energetic demands these rapidly dividing cells. The underlying regulators tumor metabolic program are not completely understood; however, factors have potential as therapy targets. Here, we determined that upregulation oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known NCOA2, drives glutamine-dependent de novo lipogenesis, which eventual metastasis....
The ERBB family of type 1 receptor tyrosine kinases and their ligands have crucial functions during mammopoiesis, but the signaling networks that ultimately regulate activity in breast remained elusive. Here, we show mice with Cre-lox mediated deletions both Erbb4 alleles within developing mammary gland (Erbb4(Flox/Flox)Wap-Cre) fail to accumulate lobuloalveoli or successfully engage lactation at parturition owing, part, impaired epithelial proliferation. Analysis differentiation factor...
Lung cancer remains the leading cause of death. Genome sequencing lung tumors from patients with squamous cell carcinoma has identified SMAD4 to be frequently mutated. Here, we use a mouse model determine molecular mechanisms by which Smad4 loss leads progression. Mice ablation Pten and in airway epithelium develop metastatic adenosquamous tumors. Comparative transcriptomic vivo cistromic analyses that PTEN results ELF3 ErbB2 pathway activation due decreased expression ERRFI1, negative...
The proteasome activator REGγ mediates a shortcut for the destruction of intact mammalian proteins. biological roles and underlying mechanisms are not fully understood. Here we provide evidence that regulates cellular distribution p53 by facilitating its multiple monoubiquitylation subsequent nuclear export degradation. We also show inhibition tetramerization might further enhance cytoplasmic relocation reduce active in nucleus. Furthermore, enhances physical interaction with HDM2 probably...
The human steroid receptor RNA activator (SRA) gene encodes both noncoding RNAs (ncRNAs) and protein-generating isoforms. In reporter assays, SRA ncRNA enhances nuclear myogenic differentiation 1 (MyoD)-mediated transcription but also participates in specific corepressor complexes, serving as a distinct scaffold. That levels might affect some biological functions, such proliferation, apoptosis, steroidogenesis, myogenesis, has been reported. However, the breadth of endogenous target genes...
Acer truncatum is an important ornamental, edible, and medicinal plant resource in China. Previous phytochemical research has focused on the leaf (AL) due to its long history as a tea for health. Other parts such branch (ABr), bark (ABa), fruit (AF), root (AR) have drawn little attention regarding their metabolites bioactivities. The strategy of in-house chemical library combined with Progenesis QI informatics platform was applied characterize metabolites. A total 98 compounds were...
Abstract Despite a regain of interest recently in ERK3 kinase signaling, the molecular regulations both gene expression and protein activity are still largely unknown. While it is shown that disruption causes neonatal lethality, cell type‐specific functions signaling remain to be explored. In this study, we report upregulated by cytokines through c‐Jun endothelial cells; binds regulates its transcription. We further reveal new role for regulating migration, proliferation tube formation...
// Ka Bian 2 , Naveen Reddy Muppani 1 Lobna Elkhadragy Wei Wang 3 Cheng Zhang Tenghui Chen 4 Sungyun Jung Ole Morten Seternes 5 and Weiwen Long 1,2 Department of Biochemistry Molecular Biology, Wright State University, Dayton, OH, USA Otorhinolaryngology, Tangdu Hospital, The Fourth Military Medical Xi'an, China Cellular Baylor College Medicine, Houston, TX, Bioinformatics Computational University Texas MD Anderson Cancer Center, Pharmacy, Tromsoe, N-Tromsoe, Norway Correspondence to: Long,...
T helper 17 (Th17) cell development is programmed by the orphan nuclear receptor RORγt, but underlying mechanism not well understood. Nuclear receptor-mediated transcriptional activation depends on coactivators. Here, we show that steroid coactivator-3 (SRC-3) critically regulates Th17 differentiation. Reduced incidence of experimental autoimmune encephalitis (EAE) associated with decreased generation in vivo was observed mice SRC-3 deletion specifically cells. In vitro, deficiency did...
The related coactivators SRC-2 and SRC-3 interact with peroxisome proliferator activated receptor γ (PPARγ) to coordinate transcriptional circuits promote adipogenesis. To identify potential coactivator redundancy during human adipogenesis at single cell resolution, we used high content analysis quantify links between PPARγ, SRC-2, SRC-3, lipogenesis. Because detected robust increases significant cell–cell heterogeneity in PPARγ lipogenesis, without changes or hypothesized that permissive...
Extracellular signal‐regulated kinase 3 ( ERK 3) is an atypical mitogen‐activated protein MAPK ), whose biological activity tightly regulated by its cellular abundance. Recent studies have revealed that upregulated in multiple cancers and promotes cancer cell migration/invasion drug resistance. Little known, however, about how expression level cancers. Here, we identified the oncogenic polycomb group BMI 1 as a positive regulator of head neck cells. Mechanistically, upregulates suppressing...
F-box proteins, such as F-box/WD repeat-containing protein 7 (FBW7), are essential components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases. They bind to S-phase kinase-associated 1 (SKP1) through motif and deliver their substrate ligase complex for ubiquitination subsequent degradation. leucine-rich repeat 16 (FBXL16) is a poorly studied protein. Because it does not interact with scaffold cullin (CUL1), we hypothesized that FBXL16 might form functional SCF-E3 complex. In present study,...
Abstract ΔNp63α, a member of the p53 family transcription factors, is overexpressed in number cancers and plays role proliferation, differentiation, migration, invasion. ΔNp63α has been shown to regulate several microRNAs that are involved development cancer. We identified miRNA miR-320a as positively regulated target ΔNp63α. Previous studies have downregulated colorectal cancer targets small GTPase Rac1, leading reduction noncanonical WNT signaling EMT, thereby inhibiting tumor metastasis...
Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein (MAPK) family. It harbors a domain in N-terminus and long C-terminus extension. The extension comprises conserved ERK3 ERK4 (C34) region unique tail, which was shown to be required for interaction with cytoskeletal septin 7. Recent studies have elucidated role signaling promoting motility invasiveness cancer cells. However, little known about intramolecular regulation enzymatic activity...
Abstract Background p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α main isoform p63 highly expressed in Non-melanoma skin cancer (NMSC). Extracellular signal-regulated kinase 3 (ERK3) atypical mitogen-activated protein (MAPK) whose biochemical features cellular regulation are distinct from those conventional MAPKs such as ERK1/2. While ERK3 has been shown to be upregulated lung cancers head neck cancers, which it promotes...