A5079239183- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Neurogenetic and Muscular Disorders Research
- TGF-β signaling in diseases
- CAR-T cell therapy research
- Indoor Air Quality and Microbial Exposure
- Financial Literacy, Pension, Retirement Analysis
- Occupational and environmental lung diseases
- Neurogenesis and neuroplasticity mechanisms
- Monoclonal and Polyclonal Antibodies Research
- MicroRNA in disease regulation
- Renal and related cancers
- Growth Hormone and Insulin-like Growth Factors
- Finance, Taxation, and Governance
- Air Quality and Health Impacts
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital Anomalies and Fetal Surgery
Ollscoil na Gaillimhe – University of Galway
2005-2022
Applied Mathematics (United States)
2020
King's College London
2010
Guy's Hospital
2010
University of Scranton
2002
Polyclonal T-cells can be directed against cancer using transmembrane fusion molecules known as chimeric antigen receptors (CARs). Although preclinical studies have provided encouragement, pioneering clinical trials CAR-based immunotherapy been disappointing. Key obstacles are the need for robust expansion ex vivo followed by sustained survival of infused in patients. To address this, we developed a system to achieve selective proliferation CAR(+) IL-4, cytokine with several pathophysiologic...
Development of an accurate and affordable test for the non-invasive prenatal diagnosis Duchenne Becker muscular dystrophies (DMD/BMD) to implement in clinical practice.Cell-free DNA was extracted from maternal blood prepared massively parallel sequencing on Illumina MiSeq by targeted capture enrichment single nucleotide polymorphisms (SNPs) across dystrophin gene chromosome X. Sequencing data were analysed relative haplotype dosage.Seven healthy pregnant donors two DMD carriers all bearing a...
Although technically possible, few clinical laboratories across the world have implemented non-invasive prenatal diagnosis (NIPD) for selected single-gene disorders, mostly owing to elevated costs incurred. Having previously proven that NIPD X-linked disorders can be feasibly in practice, we now developed a test of an autosomal-recessive disorder, spinal muscular atrophy (SMA). Cell-free DNA was extracted from maternal blood and prepared massively parallel sequencing on Illumina MiSeq by...
The major histocompatibility (MHC) molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver may occur in gaps capacity present dependent MHC genotype. If this is correct, it has important implications for understanding oncogenesis and help predict based genotype data. In support hypothesis, been reported frequently tend be poorly presented by common...
MHC molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver may occur in gaps capacity present dependent genotype. If this is correct, it help predict likely be observed an individual genotype data. Two papers supporting were published Cell, reporting frequently tend poorly presented by common alleles and proposing predictive a patient. Here we...
Abstract The major histocompatibility (MHC) molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver may occur in gaps capacity present dependent MHC genotype. If this is correct, it has important implications for understanding oncogenesis and help predict based genotype data. In support hypothesis, been reported frequently tend be poorly presented by...
BiP/GRP78, an endoplasmic reticulum (ER)-resident chaperone involved in the unfolded protein response (UPR), is upregulated during myelination and can promote survival myelinating oligodendrFocytes. The chemical BiP inducer X (BIX) has been shown to preferentially activate BiP/GRP78 through ATF6 arm of UPR and, following reports beneficial effects BIX on cultured neurons subject ER stress, we studied mixed spinal cord cultures neonatal cerebellar slice cultures. cell culture model comprises...