A5045437780- Neurogenesis and neuroplasticity mechanisms
- Plant Virus Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Immune Response and Inflammation
- RNA regulation and disease
- Inflammasome and immune disorders
- Fibroblast Growth Factor Research
- Axon Guidance and Neuronal Signaling
- Milk Quality and Mastitis in Dairy Cows
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Probiotics and Fermented Foods
University of Glasgow
2020-2023
Trinity College
2021
Trinity College Dublin
2021
University of Vermont
2015
Iron released from oligodendrocytes during demyelination or derived haemoglobin breakdown products is believed to amplify oxidative tissue injury in multiple sclerosis (MS). However, the pathophysiological significance of iron-containing themselves rarely considered context MS and their cellular specificity mode action remain unclear. Using myelinating cell cultures, we now report cytotoxic potential hemin (ferriprotoporphyrin IX chloride), a major degradation product haemoglobin, 25-fold...
Abstract Double stranded RNA is generated during viral replication. The synthetic analogue poly I:C frequently used to mimic anti-viral innate immune responses in models of psychiatric and neurodegenerative disorders including schizophrenia, autism, Parkinson’s disease Alzheimer’s disease. Many studies perform limited analysis immunity despite these potentially differing as a function dsRNA molecular weight age. Therefore fundamental questions relevant impacts systemic infection on brain...
Abstract Progressive multi-focal leukoencephalopathy (PML) is a potentially fatal encephalitis caused by JC polyomavirus (JCV). PML principally affects people with compromised immune system, such as patients multiple sclerosis (MS) receiving treatment natalizumab. However, intrathecal synthesis of lipid-reactive IgM in MS associated markedly lower incidence natalizumab-associated compared to those without this antibody repertoire. Here we demonstrate that subset human and murine IgMs induce...
Fibroblast growth factor (FGF) signalling is dysregulated in multiple sclerosis (MS) and other neurological psychiatric conditions, but there little or no consensus as to how individual FGF family members contribute disease pathogenesis. Lesion development MS associated with increased expression of FGF1, FGF2 FGF9, all which modulate remyelination a variety experimental settings. However, FGF9 also selectively upregulated major depressive disorder (MDD), prompting us speculate it may have...
BiP/GRP78, an endoplasmic reticulum (ER)-resident chaperone involved in the unfolded protein response (UPR), is upregulated during myelination and can promote survival myelinating oligodendrFocytes. The chemical BiP inducer X (BIX) has been shown to preferentially activate BiP/GRP78 through ATF6 arm of UPR and, following reports beneficial effects BIX on cultured neurons subject ER stress, we studied mixed spinal cord cultures neonatal cerebellar slice cultures. cell culture model comprises...