A5051324532- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Neural dynamics and brain function
- Intensive Care Unit Cognitive Disorders
- Tryptophan and brain disorders
- Biochemical effects in animals
- RNA regulation and disease
- Anesthesia and Neurotoxicity Research
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Neuroscience and Neural Engineering
- interferon and immune responses
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Connexins and lens biology
- Intracerebral and Subarachnoid Hemorrhage Research
- Trace Elements in Health
- Prenatal Substance Exposure Effects
- Occupational and environmental lung diseases
University of California, Riverside
2020-2025
Trinity College Dublin
2018-2024
Trinity College
2021
Universidade Federal de Ciências da Saúde de Porto Alegre
2016-2018
Universidade Federal do Rio Grande do Sul
2008-2017
Type I interferons (IFN-I) are the principal antiviral molecules of innate immune system and can be made by most cell types, including central nervous cells. IFN-I has been implicated in neuroinflammation during neurodegeneration, but its mechanism induction consequences remain unclear. In current study, we assessed expression murine prion disease (ME7) examined contribution receptor IFNAR1 to progression. The data indicate a robust IFNβ response, specifically microglia, with evidence...
Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood cognition. In vulnerable individuals, acute illness also produce profound, maladaptive, cognitive dysfunction including delirium, but our understanding delirium pathophysiology remains limited. Here, we used bacterial lipopolysaccharide (LPS) in female C57BL/6J mice hip fracture humans to address whether disrupted energy metabolism...
Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of also contribute rates long-term decline, implying that these acute events induce injury. Whether systemic inflammation-induced dysfunction brain injury occur by overlapping or discrete mechanisms remains unexplored. Here we show inflammation, induced bacterial LPS, produces both working-memory deficits in the degenerating dissociable IL-1-dependent processes....
Abstract Age is a significant but heterogeneous risk factor for acute neuropsychiatric disturbances such as delirium. Neuroinflammation increases with aging the determinants of underlying dysfunction upon systemic inflammation are not clear. We hypothesised that, advancing age, mice would become progressively more vulnerable to cognitive and that neuroinflammation neuronal integrity might predict heterogeneity in vulnerability. Here we show region-dependent differential expression microglial...
Abstract Background Inflammatory responses in brain are primarily mediated by microglia, but growing evidence suggests a crucial importance of astrocytes. S100B, calcium-binding protein secreted astrocytes, has properties neurotrophic or an inflammatory cytokine. However, it is not known whether primary signals occurring during induction response (e.g. lipopolysaccharide, LPS) directly modulate S100B. Methods In this work, we evaluated S100B levels cerebrospinal fluid (CSF) and serum Wistar...
Physical exercise effects on brain health and cognitive performance have been described. Synaptic remodeling in hippocampus induced by physical has described animal models, but the underlying mechanisms remain poorly understood. Changes astrocytes, glial cells involved synaptic remodeling, need more characterization. We investigated effect of moderate treadmill (20 min/day) for 4 weeks some parameters astrocytic activity rat hippocampal slices, namely, fibrillary acidic protein (GFAP),...
Data from epidemiological studies suggest that prenatal exposure to bacterial and viral infection is an important environmental risk factor for schizophrenia. The maternal immune activation (MIA) animal model used study how insult directed at the host can have adverse effects on fetus, leading behavioral neurochemical changes later in life. We evaluated whether administration of LPS rat dams during late pregnancy affects astroglial markers (S100B GFAP) offspring frontal cortex hippocampus...
Abstract Behavioral flexibility, the ability to adjust behavioral strategies in response changing environmental contingencies and internal demands, is fundamental cognitive functions. Despite a large body of pharmacology lesion studies, precise neurophysiological mechanisms that underlie flexibility are still under active investigations. This work aimed determine role brainstem-to-prefrontal cortex circuit flexible rule switching. We trained mice perform set-shifting task, which they learned...
Abstract Behavioral flexibility, the ability to adjust behavioral strategies in response changing environmental contingencies and internal demands, is fundamental cognitive functions. Despite a large body of pharmacology lesion studies, precise neurophysiological mechanisms that underlie flexibility are still under active investigations. This work aimed determine role brainstem-to-prefrontal cortex circuit flexible rule switching. We trained mice perform set-shifting task, which they learned...
Diabetes mellitus (DM) has been studied recently as a major cause of cognitive deficits, memory and neurodegenerative damage. Taurine enriched environment have stood out for presenting neuroprotective stimulating effects that deserve further study. In this paper, we examined the taurine in context diabetes, evaluating on behaviour, memory, death cellular activity. Eighty-eight Wistar rats were divided into 2 groups (E = environment; C standard housing). Some animals (24/group) underwent...
Ammonia is putatively the major toxin associated with hepatic encephalopathy (HE), a neuropsychiatric manifestation that results in cognitive impairment, poor concentration and psychomotor alterations. The hippocampus, brain region involved impairment depressive behavior, has been studied less than neocortical regions. Herein, we investigated hippocampal astrocyte parameters hyperammonemic model without lesion acute slices exposed to ammonia. We also measured BDNF, neurotrophin commonly...
Both glial fibrillary acidic protein (GFAP) and S100B have been used as markers of astroglial plasticity, particularly in brain injury; however, they do not necessarily change the same time frame or direction. Herein, we induced a Parkinson’s disease (PD) model via 6-OHDA intrastriatal injection rats investigated changes GFAP using ELISA substantia nigra (SN), striatum, cerebrospinal fluid on 1st, 7th, 21st days following injection. The was validated measurements rotational behaviour by...
Astrocytes express dopamine receptors and respond to stimulation. However, the role of astrocytes in psychiatric disorders effects antipsychotics on astroglial cells have only been investigated recently. S100B is a glial-derived protein, commonly used as marker activation disorders, particularly schizophrenia. We secretion three different rat brain preparations (fresh hippocampal slices, C6 glioma primary astrocyte cultures) exposed apomorphine (haloperidol risperidone), aiming evaluate, ex...
Aquaporin-4 (AQP-4) is the principal brain water channel and predominantly expressed in astrocytes suggesting its dynamic involvement homeostasis tissue. Due to co-localization of AQP-4 inward rectifier K+ channels Kir 4.1, a functional coupling between these proteins has been proposed. putative role physiopathology disorders including epilepsy trauma. S100B calcium-binding protein secreted by astrocytes, commonly used as parameter astroglial activation. Here, we investigate possible link...