A5008590713- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Mesenchymal stem cell research
- Adenosine and Purinergic Signaling
- Alzheimer's disease research and treatments
- Birth, Development, and Health
- Electrospun Nanofibers in Biomedical Applications
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Aldose Reductase and Taurine
- Biochemical effects in animals
- Glioma Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Reproductive Biology and Fertility
- Periodontal Regeneration and Treatments
- Sperm and Testicular Function
- Wound Healing and Treatments
- Anesthesia and Neurotoxicity Research
- Sulfur Compounds in Biology
- Animal Genetics and Reproduction
- Tissue Engineering and Regenerative Medicine
- Prenatal Substance Exposure Effects
Universidade Federal de Ciências da Saúde de Porto Alegre
2014-2024
Committee on Publication Ethics
2019
Creative Commons
2019
University of Health Sciences Antigua
2016
University of Health Sciences
2016
Universidade Federal do Rio Grande do Sul
2008-2014
Hospital de Clínicas de Porto Alegre
2011-2014
Universidade Estadual de Maringá
2009
Fundação Faculdade de Medicina
2007-2008
Universidade de São Paulo
2003
Early-life environmental events can induce profound long-lasting changes in several behavioral and neuroendocrine systems. The neonatal handling procedure, which involves repeated brief maternal separations followed by experimental manipulations, reduces stress responses sexual behavior adult rats. purpose of this study was to analyze the effects on social behaviors male female rats adulthood, as manifest results memory interaction tests. number oxytocin (OT) vasopressin (VP) neurons...
Air pollution is a public health concern that has been associated with adverse effects on the development and functions of central nervous system (CNS). However, studies exposure to pollutants CNS across entire developmental period still remain scarce. In this study, we investigated impacts prenatal and/or postnatal fine particulate matter (PM2.5) from São Paulo city, brain structure behavior juvenile male mice. BALB/c mice were exposed PM2.5 concentrated ambient particles (CAP) at daily...
The morbidity of acute respiratory infections in young children and the role viruses were evaluated a 29-month household-based study an impoverished urban population Fortaleza, Brazil; subjects 175 <5 years age 63 families. Home visits conducted three times weekly during which staff recorded presence systemic symptoms collected upper tract samples for viral isolation. A large sustained burden illness was observed, isolated 35% collected. Of isolates, 45.6% rhinoviruses, 16% parainfluenza...
Lesions with great loss of skin and extensive burns are usually treated heterologous grafts, which may lead rejection. Cell therapy mesenchymal stem cells is arising as a new proposal to accelerate the healing process. We tested consisting sodium carboxymethylcellulose (CMC) biomaterial, in combination adipose-derived (ADSCs), treat lesions an vivo rat model. This biomaterial did not affect membrane viability induced small transient genotoxicity, only at highest concentration (40 mg/mL). In...
Abstract BACKGROUND: Nonsmall cell lung cancer (NSCLC) is the major determinant of overall mortality worldwide. Despite progress in molecular research, current treatments offer limited benefits. Because NSCLC generates early metastasis, and this behavior requires great motility, herein authors assessed potential value CFL1 gene (main member invasion/metastasis pathway) as a prognostic predictive biomarker. METHODS: Metadata analysis tumor tissue microarray was applied to examine expression...
Chronic hyperglycemia increases oxidative stress status and has been associated with neurological complications in diabetic individuals. This study compared the antioxidant properties of red wine or resveratrol different brain areas non-diabetic rats, investigated effect them on hippocampal cell proliferation dentate gyrus rats. Streptozotocin-induced control rats were treated (4 mL/kg), (20 mg/kg), saline, by oral gavage, for 21 days. Lipid peroxidation (TBARS), catalase superoxide...
Congenital hypothyroidism is associated with delay in cell migration and proliferation brain tissue, impairment of synapse formation, misregulation neurotransmitters, hypomyelination mental retardation. However, the mechanisms underlying neuropsychological deficits observed congenital are not completely understood. In present study we proposed a mechanism by which leads to hippocampal neurotoxicity. induces c-Jun-N-terminal kinase (JNK) pathway activation leading hyperphosphorylation glial...
Diabetes mellitus (DM) has been studied recently as a major cause of cognitive deficits, memory and neurodegenerative damage. Taurine enriched environment have stood out for presenting neuroprotective stimulating effects that deserve further study. In this paper, we examined the taurine in context diabetes, evaluating on behaviour, memory, death cellular activity. Eighty-eight Wistar rats were divided into 2 groups (E = environment; C standard housing). Some animals (24/group) underwent...
Medulloblastoma (MB) is the most common malignant brain tumor in childhood. The alterations found include: presence of oncoproteins p53 and HER2, elevated mitotic index, neuronal differentiation. aim this study was to determine immunohistochemical expression markers Ki-67, NeuN, synaptophysin, HER2 40 MB samples their correlation with clinicopathologic parameters survival. In 29 patients (72.5%), >20% cells were positive for Ki-67. Males showed greater ki-67 (p=0.02) smaller survival rates...
The present study investigated the neuroprotective effect of taurine against deleterious effects chronic-recurrent neuroinflammation induced by LPS in cerebellum rats. Adult male Wistar rats were treated with for 28 days. Taurine was administered at a dose 30 or 100 mg/kg, gavage. On days 7, 14, 21, and 28, animals received (250 μg/kg) intraperitoneally. vehicle used saline. divided into six groups: vehicle, LPS, plus mg/kg. day 29, euthanized, removed prepared immunofluorescence analysis...