A5081418182- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Mitochondrial Function and Pathology
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Psychology and Mental Health
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Pluripotent Stem Cells Research
- Neurological Disorders and Treatments
- Autism Spectrum Disorder Research
- HIV Research and Treatment
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- COVID-19 and Mental Health
- Acute Ischemic Stroke Management
- Adolescent and Pediatric Healthcare
- Metabolomics and Mass Spectrometry Studies
- Adenosine and Purinergic Signaling
- Stroke Rehabilitation and Recovery
The University of Texas Health Science Center at Houston
2016-2025
The University of Texas at Austin
2015-2021
Houston Methodist
2021
Methodist Hospital
2021
Cornell University
2021
Weill Cornell Medicine
2021
University of Washington
2021
Universidade Federal do Rio Grande do Sul
2010-2019
Hospital de Clínicas de Porto Alegre
2010-2019
National Institute on Population Medical Genetics
2010
Sex differences in COVID-19 are increasingly recognized globally. Although infection rates similar between the sexes, men have more severe illness. The mechanism underlying these sex is unknown, but a differential immune response to has been implicated several recent studies. However, how shape remains understudied.We collected demographics and blood samples from over 600 hospitalized patients diagnosed with May 24th 2020 April 28th, 2021. These were divided into two cohorts: Cohort 1 was...
Objective There are several models of staging in bipolar disorder ( BD ), but none has been validated. The aims this study were to empirically investigate clinical variables that may be useful classify patients clusters according stage and the association with biomarkers as biological validators. Method This was a historical cohort study. Patients n = 115) diagnosed not an acute episode first‐degree relatives 25) recruited. Sociodemographic, clinical, functional data collected. Serum...
Bipolar disorder (BD) is a severe chronic psychiatric that has been associated with cellular dysfunctions related to mitochondria, neurotrophin levels, and oxidative stress. Evidence shown endoplasmic reticulum (ER) stress may be common pathway of the changes described in BD. In present study we assessed unfolded protein response (UPR) effects this process on lymphocytes from patients We also evaluated whether stage chronicity BD was UPR parameters. Cultured 30 32 age- sex-matched controls...
Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and brain. Experimental clinical studies have suggested presence of neuroinflammation in schizophrenia. In present study, effect antipsychotic drugs, including clozapine, risperidone, haloperidol (10, 20 μM, respectively), on production IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-17, IL-18, INF-γ, TNF-α was investigated unstimulated polyriboinosinic-polyribocytidilic acid [poly...
Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial (EIM) have been limited. Additionally, male bias in disease severity mortality after evident globally. Sex differences immune response to may mediate this disparity. We investigated BIM, EIM inflammatory cytokine/chemokine (CC) levels across sexes.Plasma samples from 57 subjects at < 48 h hospitalization, 20 matched...
<h3>Objective</h3> To define the role played by microglia in different stages of Huntington disease (HD), we used TSPO radioligand [11C]-ER176 and PET to evaluate microglial activation relation neurodegeneration clinical features seen at premanifest manifest disease. <h3>Methods</h3> This is a cross-sectional study which 18 subjects (6 controls, 6 premanifest, HD gene carriers) underwent scan an MRI for anatomic localization. Segmentation regions interest (ROIs) was performed, group...
Systemic toxicity is a relevant dimension of pathophysiology in bipolar disorder, and oxidative damage one potential link between central peripheral pathology. Although there mounting evidence that chronic disorder associated with stress, studies the early stages are scarce, heavily reliant on clinical lieu population studies. The objective this study was to confirm leading hypotheses about role disorder. To end, we nested case-control population-based young adults aged 18–24 yr. After an...
Neuroinflammation has been implicated in the pathophysiology of bipolar disorder. Some evidence shows that nonsteroidal anti-inflammatory drugs (NSAIDs) have promising antidepressant effects. The antioxidant N-acetylcysteine (NAC) may enhance effects NSAIDs. No study has, however, tested adjunctive therapeutic benefits an NSAID and NAC disorder.The sample included 24 medicated patients diagnosed with DSM-IV-TR disorder who were aged 18-65 years had a Montgomery-Asberg Depression Rating Scale...
Abstract Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic death. Although males are more susceptible severe and higher mortality due COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers therapeutic targets treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected SARS-CoV-2-positive male female patients with Key pathways that demonstrated robust...