A5085380040- Genetic Neurodegenerative Diseases
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Autism Spectrum Disorder Research
- Bipolar Disorder and Treatment
- Nerve injury and regeneration
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Renin-Angiotensin System Studies
- Alzheimer's disease research and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Dementia and Cognitive Impairment Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Nutrition and Feeding Issues
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Migraine and Headache Studies
- Apelin-related biomedical research
- Systemic Lupus Erythematosus Research
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Amyotrophic Lateral Sclerosis Research
- Infectious Encephalopathies and Encephalitis
- HIV Research and Treatment
The University of Texas Health Science Center at Houston
2016-2025
Huntington's Disease Society of America
2022-2024
Universidade Federal de Minas Gerais
2014-2023
Faculdade Frassinetti do Recife
2022
Universidade de Pernambuco
2022
Mayo Clinic
2022
University of Washington
2021
Houston Methodist
2021
Cornell University
2021
Weill Cornell Medicine
2021
This study tested the hypothesis that low-grade inflammation presented in patients with bipolar disorder (BD) is associated expansion of activated T cells, and this state may be due to a lack peripheral regulatory cells. Specifically, we investigated distribution monocytes lymphocyte subsets, Th1/Th2/Th17 cytokines plasma by flow cytometry. Twenty-one BD type I 21 age- sex-matched controls were recruited for study. had increased proportions (CD14+). Regarding populations, reduced cells...
The renin-angiotensin system (RAS) is a dual with two opposite arms: i) the classical one formed by angiotensin converting enzyme (ACE), (Ang) II and type 1 (AT1) receptors; ii) counter-regulatory arm consisting of ACE2, Ang-(1-7) Mas receptor. Physical exercise can modulate this system, however, only animal studies have compared effects different intensity protocols on RAS. No data humans were provided. Therefore, we investigated acute effect isowork aerobic [High-Intensity Interval...
<h3>Objective</h3> To define the role played by microglia in different stages of Huntington disease (HD), we used TSPO radioligand [11C]-ER176 and PET to evaluate microglial activation relation neurodegeneration clinical features seen at premanifest manifest disease. <h3>Methods</h3> This is a cross-sectional study which 18 subjects (6 controls, 6 premanifest, HD gene carriers) underwent scan an MRI for anatomic localization. Segmentation regions interest (ROIs) was performed, group...
Background: Acute kidney injury (AKI) is an uncommon but serious complication after trauma.The objective of this study was to evaluate the prevalence, clinical characteristics and outcome AKI trauma.Patients Methods: This a retrospective performed from January 2006 2008 in emergency specialized hospital Fortaleza city, northeast Brazil.All patients with admitted period were included.Prevalence AKI, investigated.Results: Of 129 intensive care unit (ICU), 52 had AKI.The mean age 30.1 ± 19.2...
Neurotrophic factors regulate the survival and growth of neurons, influence synaptic efficiency plasticity. Several studies suggest existence a relationship between changes in neurotrophic levels bipolar disorder (BD). The glial cell-line derived factor (GDNF) influences monoaminergic neurons cells, but its role BD patients is controversial. In order to elucidate it we evaluated plasma GDNF sample 70 (35 mania 35 euthymia) compared with 50 healthy controls matched for age, gender educational...