A5091476119- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Cardiac Health and Mental Health
- Hormonal Regulation and Hypertension
- Hearing Loss and Rehabilitation
- Adolescent and Pediatric Healthcare
- Circadian rhythm and melatonin
- Health, psychology, and well-being
- Neuroendocrine regulation and behavior
- Maternal Mental Health During Pregnancy and Postpartum
- Autoimmune and Inflammatory Disorders Research
- Noise Effects and Management
- Electrolyte and hormonal disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Heart Rate Variability and Autonomic Control
- Adrenal Hormones and Disorders
- Music Therapy and Health
- Sleep and related disorders
- Neurogenesis and neuroplasticity mechanisms
- Hormonal and reproductive studies
- Frailty in Older Adults
- Family and Disability Support Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiovascular Disease and Adiposity
- RNA Research and Splicing
William Harvey Research Institute
2017-2024
Queen Mary University of London
2017-2024
Universidade de São Paulo
2006-2024
Universidade Federal de Sergipe
2024
University College London
2012-2018
Royal London Hospital
2018
Université du Québec à Montréal
2018
Institut Universitaire de Gériatrie de Montréal
2018
Hospital Pró-Cardíaco
2017
Medical University of Lodz
2013-2014
Antidepressants increase adult hippocampal neurogenesis in animal models, but the underlying molecular mechanisms are unknown. In this study, we used human progenitor cells to investigate pathways involved antidepressant-induced modulation of neurogenesis. Because our previous studies have shown that antidepressants regulate glucocorticoid receptor (GR) function, specifically tested whether GR may be effects these drugs on We found treatment (for 3-10 days) with antidepressant, sertraline,...
While comorbidity between coronary heart disease (CHD) and depression is evident, it unclear whether the two diseases have shared underlying mechanisms. We performed a range of analyses in 367,703 unrelated middle-aged participants European ancestry from UK Biobank, population-based cohort study, to assess primarily due genetic or environmental factors, test cardiovascular risk factors CHD are likely be causally related using Mendelian randomization. showed family history was associated with...
BackgroundPeripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus investigation.MethodsWe used microarray data on whole blood from two independent case-control studies MDD: the GlaxoSmithKline–High-Throughput Disease-specific target Identification Program [GSK-HiTDiP] study (113 patients 57 healthy control subjects) Janssen–Brain Resource Company (94 100 subjects). Genome-wide differential gene expression...
Evidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised biomarkers persistence depressive symptoms. We examined temporal serum levels symptoms among older participants.Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess at baseline 5-year follow-up in 656 participants (233 men, 423 women) aged >60 years...
Significance These findings indicate that the combination of shorter leukocyte telomeres with high telomerase activity is associated stress-related impairment function at both biological and psychological levels. Slow poststress recovery in cardiovascular inflammatory responses reduced stress responsivity blood pressure cortisol are indicative a state heightened allostatic load. Older men telomere/high phenotype also show impoverished resources for dealing stress, including low levels social...
There is growing evidence that psychosocial interventions can have psychological benefits for people affected by cancer, including improved symptoms of mental health and wellbeing optimised immune responses. However, despite numbers music interventions, particularly singing, in cancer care, there less research into their impact. We carried out a multicentre single-arm preliminary study to assess the impact singing on mood, stress response three populations cancer: carers (n = 72), bereaved...
Significance Our observations provide evidence to link epidemiological studies implicating stress-related processes with biological dysfunction in type 2 diabetes. The patterns of cardiovascular, inflammatory, neuroendocrine, and cholesterol responses exemplify the disturbances reactivity recovery predicted by allostatic load model, including prolonged stress due delayed shutdown physiological reactivity, inadequate (blunted) resulting compensatory hyperactivity other mediating pathways....
Coronary heart disease (CHD) and depression are very common often co-existing disorders. In addition to psychological social morbidity, exacerbates adverse cardiac outcomes in CHD patients. Inflammation has been proposed as one of the mechanisms involved association between these two debilitating diseases. Therefore, present study aimed evaluate inflammatory responses well investigate pathophysiological underlying putative activation patients with without depression, by assessing function...
In this study, we used new technology to investigate whether a coherent pattern of enhanced expression inflammatory and other immune activation genes in circulating monocytes is found patients with major depression. Since high state might be related glucocorticoid resistance, also included the for two isoforms receptor. For aimed at finding similar MDD recruited 47 medication-free melancholic inpatients 42 healthy controls. A quantitative-polymerase chain reaction (Q-PCR) monocyte gene...
Growing numbers of mental health organizations are developing community music-making interventions for service users; however, to date there has been little research into their efficacy or mechanisms effect. This study was an exploratory examination whether 10 weeks group drumming could improve depression, anxiety and social resilience among users compared with a non-music control (with participants allocated by geographical location.) Significant improvements were found in the but not...
Background Shorter telomere length and poor sleep are more prevalent at older ages, but their relationship is uncertain. This study explored associations between duration in a sample of healthy middle early old age people. Methods Participants were 434 men women aged 63.3 years on average drawn from the Whitehall II cohort study. Sleep was measured by self-report. Results There linear association leukocyte not (P = 0.035). Men reporting shorter had telomeres, independently age, body mass...
Relationships between cortisol responses to laboratory stress and output over the day have not been studied extensively. We tested associations a set of challenges (colour/word interference mirror tracing) three aspects day, namely total area under curve (AUCday), awakening response (CAR) slope decline day. Participants were 466 men women aged 54–76 years. found that positively associated with AUCday independently sex, age, socioeconomic status, smoking, body mass index, time testing (B =...
Objectives To examine the association between hearing impairment and incident frailty in older adults. Design Cross‐sectional longitudinal analyses with 4‐year follow‐up using data from English Longitudinal Study of Ageing. Setting Community. Participants Community‐dwelling individuals aged 60 on status (N = 2,836). Measurements Hearing was defined as poor self‐reported hearing. Having none five Fried phenotype components (slow walking, weak grip, exhaustion, weight loss low physical...
Little is known about vision impairment and frailty in older age. We investigated the relationship of poor incident prefrailty frailty.
To determine if depressive symptoms assessed near diagnosis associate with future measures of pain, disability and disease for adolescent patients diagnosed JIA.Data were analysed from JIA aged 11-16 years recruited to the Childhood Arthritis Prospective Study, a UK-based inception cohort childhood-onset arthritis. Depressive (using Mood Feelings Questionnaire; MFQ), active limited joint count, score (Childhood Health Assessment Questionnaire), pain visual analogue scale patient's general...
Abstract Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to lack of regard persistency exposure. We examined whether being inflamed multiple occasions increases new depressive symptoms using prospective data from population-based sample adults aged 50 years or older (the English Longitudinal Study Ageing). Participants with less than four eight in 2004/05 and 2008/09 based the Eight-item Centre Epidemiologic Studies Depression scale were...