A5027533532- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Frailty in Older Adults
- Telomeres, Telomerase, and Senescence
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Genetics, Aging, and Longevity in Model Organisms
- Kruppel-like factors research
- Metabolism, Diabetes, and Cancer
- Sleep and related disorders
- Cholesterol and Lipid Metabolism
- Learning Styles and Cognitive Differences
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Thermoregulation and physiological responses
- Inflammasome and immune disorders
- Genetics and Physical Performance
- Muscle metabolism and nutrition
- Cardiovascular Disease and Adiposity
- Circadian rhythm and melatonin
Cardiff Metropolitan University
2014-2025
RMIT University
2012-2015
Cardiff University
2011
University of Wales Institute Cardiff
2008-2010
Background Shorter telomere length and poor sleep are more prevalent at older ages, but their relationship is uncertain. This study explored associations between duration in a sample of healthy middle early old age people. Methods Participants were 434 men women aged 63.3 years on average drawn from the Whitehall II cohort study. Sleep was measured by self-report. Results There linear association leukocyte not (P = 0.035). Men reporting shorter had telomeres, independently age, body mass...
An important mechanism by which physical activity reduces the risk of cardiovascular disease is through regulating plasma lipids. We investigated whether low-intensity exercise modulates lipid metabolism and transcription factors peroxisome proliferator-activated receptor gamma (PPARgamma) liver X alpha (LXRalpha) responsible for controlling reverse cholesterol transport (RCT).Thirty-four sedentary adults, mean age 45.6 +/- 11.1 yr, participated in an 8-wk program consisting walking 10,000...
The aim of the present study was to test hypotheses that exercise is associated with generation peroxisome proliferator-activated receptor-γ (PPARγ) ligands in plasma and this may activate PPARγ signaling within circulating monocytes, thus providing a mechanism underpin exercise-induced antiatherogenic benefits observed previous studies. A cohort healthy individuals undertook an 8-wk exercise-training program; samples were obtained before (Pre) after (Post) standardized submaximal bouts (45...
Hostility is associated with a significantly increased risk of age-related disease and mortality, yet the pathophysiological mechanisms involved remain unclear. Here we investigated hypothesis that hostility might impact health by promoting cellular aging.We tested relationship between cynical two known markers aging, leukocyte telomere length (TL) telomerase activity (TA), in 434 men women from Whitehall II cohort.High-hostile had shorter TL than their low-hostile counterparts. They also...
to evaluate the relationship between serum levels of soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail non-frail older adults.we studied 691 subjects (141 550 non-frail) with a median age 75 years from two population-based cohorts, Toledo Study Healthy Aging AMI study, who were enrolled FRAILOMIC initiative. Multivariate Cox proportional hazards regression Kaplan-Meier survival analysis used assess baseline sRAGE mortality.during 6 follow-up 101 participants...
We previously proposed 5′-AMP-activated protein kinase (AMPK) dephosphorylation within immune cells as an intracellular mechanism linking exercise and immunosuppression. In this study, AMPK phosphorylation underwent transient (<1 h) decreases (53.8 ± 7.2% basal) immediately after (45 min of cycling at 70% V̇o 2max ) in a cohort 16 adult male participants. Similar effects were seen with running. However, because exercise-induced inactivation was shown to occur AMP-independent manner, the...
<b><i>Introduction:</i></b> Frailty is prevalent among older adults with diabetes mellitus. Elevated serum levels of the soluble receptor for advanced glycation-end products (sRAGE) predict mortality in frail adults. The evidence that sRAGE also related to higher mellitus inconsistent. Therefore, this study explored if frailty status influences relationship between and condition. <b><i>Methods:</i></b> We analysed data 391 participants (median...
Key points Age significantly modifies the relationship between aortic pulse wave velocity and telomere length. The differential relationships observed length in younger older individuals suggest that links cellular vascular ageing reflect a complex interaction genetic environmental factors acting over life‐course. Abstract Ageing is associated with marked large artery stiffening. Telomere shortening, marker of ageing, linked arterial However, results existing studies are inconsistent,...
Peroxisome proliferator-activated receptor gamma (PPARγ) is known to be activated via exercise-associated transient increases in oxidative stress. However, the precise mechanism(s) triggering PPARγ activation monocytes during/following exercise remain confirmed. Here, two cohorts of five healthy male individuals undertook bouts (cycling; 70% VO2max; 45 min) presence/absence dietary antioxidant supplementation (vitamins C (1000 mg/day) and E (400IU/day) for four weeks before exercise);...
There is much evidence that prolonged intense exercise suppresses the immune system. However, intracellular biochemical mechanisms linking and immunosuppression remain obscure. The purpose of this study was to investigate hypothesis exercise-induced inactivation 5′AMP-activated protein kinase (AMPK) disrupts individual cell function, thus may be linked immunosuppression. To confirm AMPK’s role in cells, AMPK activity assessed cultured monocytic Mono Mac 6 (MM6) cells. effects single bouts...
Megakaryocytopoiesis is a complex differentiation process driven by the hormone thrombopoietin which haematopoietic progenitor cells give rise to megakaryocytes, giant bone marrow that in turn break down form blood platelets. The Tribbles Pseudokinase 3 gene (TRIB3) encodes pleiotropic protein increasingly implicated regulation of cellular programmes. Previous studies have hinted TRIB3 could be also involved megakaryocytopoiesis but its role this has so far not been investigated. Using model...
<b><i>Introduction:</i></b> The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status influences association. <b><i>Methods:</i></b> We analysed data 1,016 individuals (median age, 75 years) from 3 population-based European cohorts, enrolled FRAILOMIC project....
Objectives: Genomic markers linked to exercise-associated health benefits and/or sporting performance are increasingly used guide decision-making in healthcare and sport/exercise science. This project investigated whether the IL-6R SNP “rs2228145” might be provisionally designated a novel physical activity/exercise marker. rs2228145 results an Aspartate358/Alanine358 change adjacent site where protein is cleaved into two fragments, resulting ~two-fold increases blood-borne levels of soluble...
CCL11 (eotaxin-1) is a chemokine classically known to be involved in allergic responses. More recently, this mediator has been implicated age-related cognitive decline. However, data available on the relationship between and status older adults living community scarce. The aim of study was explore associations two cohorts community-based recognised for their contrasting socio-demographic environments, which participated FRAILOMIC Initiative (www.frailomic.org/ 3C-Bordeaux cohort, comprising...
Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed develop an vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding impact of rs2228145, clinically polymorphism coding region gene body’s response infection: interleukin-6 receptor (IL-6R) gene. Three monocyte-macrophage cell-lines (U937, THP-1, MM6) were shown exhibit AA, AC and CC rs2228145 genotypes, respectively, MM6...