A5048204227- Autoimmune and Inflammatory Disorders Research
- Spondyloarthritis Studies and Treatments
- Adolescent and Pediatric Healthcare
- Rheumatoid Arthritis Research and Therapies
- Childhood Cancer Survivors' Quality of Life
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Pediatric Pain Management Techniques
- Bone and Joint Diseases
- COVID-19 diagnosis using AI
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Inflammatory Myopathies and Dermatomyositis
- Child and Adolescent Health
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Neurogenetic and Muscular Disorders Research
- Family and Disability Support Research
- Anomaly Detection Techniques and Applications
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Musculoskeletal Disorders and Rehabilitation
University College London
2016-2025
University College Hospital
2012-2025
University College London Hospitals NHS Foundation Trust
2017-2025
Versus Arthritis
2013-2025
University of Manchester
2017-2023
British Society for Rheumatology
2023
Uppsala University
2023
Istituto Giannina Gaslini
2023
Centre for Epidemiology Versus Arthritis
2023
Istituto Ortopedico Gaetano Pini
2023
Background: Flare-ups in juvenile idiopathic arthritis (JIA) are characterized by joint pain and swelling often accompanied with fatigue, negative emotions, reduced participation activities. To minimize the impact of JIA on physical psychosocial development well-being young people (YP), it is essential to regularly monitor disease activity side effects, as well support self-management such adherence treatment plans engagement general health-promoting behaviors. Smartphone technology has...
To determine if depressive symptoms assessed near diagnosis associate with future measures of pain, disability and disease for adolescent patients diagnosed JIA.Data were analysed from JIA aged 11-16 years recruited to the Childhood Arthritis Prospective Study, a UK-based inception cohort childhood-onset arthritis. Depressive (using Mood Feelings Questionnaire; MFQ), active limited joint count, score (Childhood Health Assessment Questionnaire), pain visual analogue scale patient's general...
To explore whether anxiety and depression are associated with clinical measures of disease for adolescent patients juvenile idiopathic arthritis (JIA) increased peripheral proinflammatory cytokine levels in JIA healthy controls.A total 136 88 controls ages 13-18 years completed questionnaires on depressive symptoms. For JIA, pain, disability, physician global assessment (using a visual analog scale [VAS]), number joints active inflammation (active joint count) were recorded. In subsample, we...
Abstract Objectives To assess the frequency of joint inflammation detected by whole-body MRI (WBMRI) in young people (YP) with JIA and controls, to determine relationship between WBMRI-detected clinical findings. Methods YP aged 14–24 years, (patients) or arthralgia without (controls), recruited from one centre, underwent a WBMRI scan after formal assessment. Consensus at least two three independent radiologists was required define damage on WBMRI, according predefined criteria. were deemed...
This study aims to determine the prevalence of methotrexate-induced nausea and vomiting in both adolescent adult patients with inflammatory arthritis. A survey methotrexate side effects was conducted on We provided a brief questionnaire unselected arthritis being treated attending rheumatology clinics. The questions related presence, absence, severity vomiting, temporal relationship whether anti-emetics had been prescribed. total 106 from age 13 years above--57 adults (over 20 years) 49...
The aim was to evaluate diffusion-weighted imaging (DWI) as a tool for measuring treatment response in adolescents with enthesitis-related arthropathy (ERA).Twenty-two ERA underwent routine MRI and DWI before after TNF inhibitor therapy. Each patient's images were visually scored by two radiologists using the Spondyloarthritis Research Consortium of Canada system, sacroiliac joint apparent diffusion coefficient (ADC) normalized ADC (nADC) measured each patient. Therapeutic clinical defined...
Objective: To investigate the use of a quantitative diffusion-weighted imaging (DWI) tool for measuring inflammation sacroiliac joints (SIJs) in enthesitis-related arthritis (ERA). Methods: A retrospective study was performed with institutional review board approval. Subjects were adolescents who had undergone MRI SIJs since January 2010. 10 patients clinical diagnosis ERA and controls mechanical back pain assessed. Axial T1 weighted, short tau inversion recovery (STIR) DWI (b-values 0, 50,...
To describe and profile abnormalities of the lumbar spine in a cohort patients with enthesitis-related arthritis (ERA) as compared to control group adolescents mechanical back pain.We performed retrospective review magnetic resonance imaging (MRI) scans 79 (58 cases, 21 controls). The study was covered by institutional board approval informed consent obtained for all clinical investigations. Images were reviewed an expert MRI reader who blinded details. presence or absence morphologic...
Abstract Objectives This study aims to explore patients' and clinicians' understanding experiences of refractory disease (RD) persistent physical emotional symptoms (PPES) in patients with inflammatory arthritis (IA), namely rheumatoid or polyarticular juvenile idiopathic from their perspectives through interviews and/or focus groups. Design A qualitative was conducted, following a pragmatic epistemology approach framework analysis employed. Methods Semi‐structured groups IA ( n = 25)...
Abstract Background/Aims Chronic inflammation in ageing is associated with loss of skeletal muscle mass and function, known as sarcopenia. Sarcopenia multimorbidity. Juvenile idiopathic arthritis (JIA) a chronic inflammatory disease that presents before age sixteen carries enhanced risk The SARC-F survey validated screening tool for aim this was to investigate the utility identifying sarcopenia JIA explore relationship between musculoskeletal (MSK) function peripheral lymphocyte profile...
Purpose To determine the extent to which apparent diffusion coefficient (ADC) values vary with skeletal maturity in adolescent joints. Materials and Methods A retrospective study was performed Institutional Review Board (IRB) approval. We used a picture archiving communication system (PACS) search identify recruit all adolescents who had undergone 1.5T magnetic resonance imaging (MRI) of sacroiliac joints (SIJs) between January 2010 June 2015, no evidence sacroiliitis normal inflammatory...
To assess the temporal relationship between initiating biologic therapy and magnetic resonance imaging (MRI) scores of inflammation structural damage in young patients with spondyloarthritis.A local adolescent/young adult patient rheumatology database was searched for ages 12-24 years who had evidence sacroiliitis on MRI a clinical diagnosis enthesitis-related arthritis (ERA) axial involvement or nonradiographic spondyloarthritis. Patients treated tumor necrosis factor inhibitor (TNFi)...
To demonstrate proof-of-concept for a quantitative MRI method using histographic analysis to assess bone marrow oedema and fat metaplasia in the sacroiliac joints.Fifty-three adolescents aged 12-23 with known or suspected sacroiliitis were prospectively recruited underwent (qMRI) scans, consisting of chemical shift-encoded (at 3 T) diffusion-weighted imaging 1.5 T), plus conventional clinical assessment. qMRI scans produced proton-density fraction (PDFF) apparent diffusion coefficient (ADC)...
To analyse and compare drug-survival of adalimumab etanercept (and their biosimilars) in biologic-naïve patients with ERA (Enthesitis-Related Arthritis).In this retrospective observational study, conventional statistics machine-learning were applied to (adalimumab, biosimilars initiated: 2009-2019) identify determinants. The primary outcome was discontinuation treatment due primary- or secondary-failure adverse drug-reactions.During the observation period, 99 188 on first-line TNF inhibitors...
Enthesitis related arthritis (ERA) is one of the most poorly understood and under-researched forms childhood arthritis. Emerging evidence suggests that inflammatory spinal occurs earlier than previously thought there may be two distinct clinical phenotypes disease. This review will highlight existing for diagnosis treatment ERA discuss unmet research needs.
Antibodies to cyclic citrullinated peptides (anti-CCP) in rheumatoid arthritis (RA) can express the inherently autoreactive gene VH 4-34, detected using rat monoclonal antibody 9G4. Patients with polyarticular subtype of juvenile idiopathic (JIA) share some but not all features adult patients RA. This study was undertaken compare serologic findings for factor (RF), anti-CCP, and 9G4-expressing anti-CCP a large JIA cohort RA patients.Serum from 88 JIA, 29 enthesitis-related arthritis, 38...
Abstract Objectives This study aims to explore patients’ and clinicians’ experiences in managing living with refractory disease (RD) persistent physical emotional symptoms (PPES) patients RA or polyarticular JIA from their perspectives through interviews and/or focus groups. Methods A qualitative exploration 25 32 multidisciplinary rheumatology healthcare professionals (HCPs) was conducted obtain participants respective understanding of RD/PPES its impact on the patient–professional...
Most cases of enterically transmitted non-A, non-B hepatitis in India have so far been attributed to E virus (HEV) infection. the documented studies focused on incidence this disease northern, western, and south central India. A small seroprevalence study was conducted eastern Indian city Patna assess degree HEV infection among acute sporadic cases. Forty-two percent (24 57) were positive for anti-HEV antibodies. Absence any serologic markers A, B, or 58% (33 with symptoms suggest that there...
While pain is a common symptom in JIA patients, it remains unclear why some patients develop ongoing or persistent pain. Complex clinical and social settings confound analysis of individual factors that may contribute to this To address this, we first undertook retrospective reports patient cohort with the aim identifying potential contributing We then carried out an experimental laboratory study, using joint inflammatory behaviour rodents, validate role these onset under controlled...
Epidemiological studies suggest chronic and recurrent pain affects around a quarter of children, while 8% report intense frequent pain. The long-term implications in childhood are uncertain. Using electronic health records (EHRs) we used both disease codes medicines prescription to investigate the scale analgesic use children young people (CYP), if and/or at an early age is associated with substance misuse, opioids, poor mental adulthood.