A5001594708- Long-Term Effects of COVID-19
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and Mental Health
- Childhood Cancer Survivors' Quality of Life
- Intensive Care Unit Cognitive Disorders
- Adolescent and Pediatric Healthcare
- Child and Adolescent Health
- Psychosomatic Disorders and Their Treatments
- Family and Patient Care in Intensive Care Units
- Multiple Sclerosis Research Studies
- SARS-CoV-2 and COVID-19 Research
- Ethics and Legal Issues in Pediatric Healthcare
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Digital Mental Health Interventions
- LGBTQ Health, Identity, and Policy
- Animal Virus Infections Studies
- Cerebral Palsy and Movement Disorders
- Autoimmune and Inflammatory Disorders Research
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- COVID-19 Clinical Research Studies
- Delphi Technique in Research
- Menstrual Health and Disorders
- Child Development and Digital Technology
University College London
2005-2025
University College London Hospitals NHS Foundation Trust
2017-2025
Royal London Hospital
2008-2024
University College Hospital
2008-2024
Bridge University
2023
Prince Charles Hospital
2023
Great Ormond Street Hospital
2008
Guy's Hospital
1997
BackgroundWe describe post-COVID symptomatology in a non-hospitalised, national sample of adolescents aged 11–17 years with PCR-confirmed SARS-CoV-2 infection compared matched negative PCR status.MethodsIn this cohort study, from the Public Health England database who tested positive for between January and March, 2021, were by month test, age, sex, geographical region to negative. 3 months after testing, subsample contacted complete detailed questionnaire, which collected data on...
The coronavirus disease 2019 (COVID-19) pandemic substantially impacted different age groups, with children and young people not exempted. Many have experienced enduring health consequences. Presently, there is no consensus on the outcomes to assess in post-COVID-19 condition. Furthermore, it unclear which measurement instruments are appropriate for use research clinical management of post-COVID-19. To address these unmet needs, we conducted a study, aiming develop core outcome set (COS) an...
Delayed puberty can be due to either constitutional delay of growth and (CDGP) or hypogonadotropic hypogonadism (HH). Differentiating between the two using current testing difficult. We assessed utility a GnRH test in combination with 3-d 19-d human chorionic gonadotropin (HCG) discriminate conditions.We performed retrospective analysis 43 boys pubertal who required induction testosterone. All were followed through puberty; 29 subsequently diagnosed CDGP 14 HH. A standard (2.5 microg/kg) was...
Adolescents undergo a period of biological, social and psychosocial development, each these domains impacts other. Psychosocial areas concern often emerge over the adolescent (such as mental health conditions, drug use risky sexual behaviour); those with chronic illness being at higher risk. The paper aims to guide practitioners on when how approach interview young people assess risk or concern. This will include putting them ease, developing rapport, seeing alone explaining confidentiality...
Introduction The destination of transgender and gender variant young people referred by the National Health Service (NHS) Gender Identity Development (GIDS) to, discharged from two English paediatric endocrine liaison clinics is not known. Methods 1151 after full assessment GIDS; 827 to University College London Hospital since 2008; 324 Leeds Children’s 2013. Discharge categorisation was agreed criteria. Eleven emigrated 51 self-discharged. 1089 had known outcomes. Results 999/1089 (91.7%)...
To describe the prevalence of long COVID in children infected for first time (n = 332) or reinfected 243) with Omicron compared test-negative 311). Overall, 12%-16% those met research definition at 3 and 6 months after infection, no evidence difference between cases positive (Pχ2 0.17).
Abstract Our previous study in children and young people (CYP) at 3- 6-months post-infection showed that 12–16% of those infected with the Omicron (B.1.1.529) variant SARS-CoV-2 met research definition Long Covid, no differences between first-positive reinfected CYP. The primary objective current is to explore impact infection on 12 months post infection. 345 CYP aged 11–17 years a first laboratory-confirmed 360 completed an online questionnaire assessing demographics, symptoms, their...
Background: Although 99% of children and young people have been exposed to SARS-CoV-2, the long-term prevalence post-COVID-19 symptoms in is unclear. The aim this study describe symptom profiles 12 months after SARS-CoV-2 testing. Method: A matched cohort a national sample 20,202 who took PCR test between September 2020 March 2021. Results: post-index-test, there was difference number reported by initial negatives never tested positive (NN) compared other three groups had at least one (p...
Abstract Purpose of Review Long COVID, or post-COVID Condition, is increasingly recognized in children and adolescents, despite being less studied compared with the adult population. Recent studies are documenting that inappropriate sinus tachycardia (IST) postural orthostatic syndrome (POTS) may be key clinical problems patients long preliminary findings have shown these important features also children. However, POTS IST poorly known among non-specialized pediatricians, this gap limit...
Cognitive impairment is often reported after SARS-CoV-2 infection, yet evidence gaps remain. We aimed to (i) report the prevalence and characteristics of children young people (CYP) reporting "brain fog" (i.e., cognitive impairment) 12-months post PCR-proven infection determine whether differences by status exist (ii) explore CYP experiencing over a 12-month period post-infection investigate relationship between poor mental health well-being, fatigue sleep problems.
Post-COVID-19 syndrome is a new condition that can have major impact on the physical and mental well-being of children young people, affecting their ability to access activities including education. Paediatricians general practitioners need be able assess manage patients with this condition; making diagnosis, excluding serious pathology, managing comorbidities accessing appropriate management are crucial. This 15 minute consultation presents an approach history taking, examination,...
Post-COVID condition (PCC) emerged following the 2020 coronavirus pandemic and required rapid service development to manage affected patients. This evaluation describes demographics, medical background, management six-month outcomes of children young people with PCC-related symptoms referred one specialist tertiary between June August 2022. Data were retrospectively collected from referral information notes. 176 patients (61% female) aged 6-18 years referred, a mean 8.2 impacting on...
To investigate adrenal function in children and adolescents with chronic fatigue syndrome (CFS) compared age-matched controls.Case-control study of low dose (500 ng/m2) synacthen tests (LDST) 23 CFS 17 controls. Serum cortisol concentrations were measured at 5-min intervals from 10 to 45 minutes. Peak serum concentration, time peak, rise area under the curve (AUC) derived.Patients had significantly lower mean levels during LDST (p <0.001), peak <0.025), reduced AUC <0.005) longer <0.05)....
We have evaluated the use of immunosuppressant mycophenolate mofetil (MMF) in treatment severe insulin resistance caused by neutralising anti-insulin antibodies type 1 diabetes mellitus (T1DM). A 12-yr-old boy with a 5-month history T1DM developed immunological secondary to human antibodies. Various different modalities, including lispro insulin, intravenous prednisolone and immunoabsorption, were tried, all without sustained response treatment. Although introduction MMF only resulted small...
Background Acne vulgaris (acne) is a common adolescent skin condition. It associated with negative psychological impacts and sufferers do not easily seek help, hence undertreated. Objectives We investigated the self-reported prevalence, severity sequelae of acne, together assessing help-seeking behaviour its barriers, in separate school hospital samples. explored opportunistic treatment by paediatricians. Methods Self-reported survey participants drawn from: (1) 120 adolescents aged 13–18...
Post-COVID services have been set up in England to treat children with ongoing symptoms of Long COVID. To date, the characteristics seeking treatment from these has not described.
Context and challengesThe Long COVID in Children Young People (CLoCk) study began April 2021 against a backdrop of uncertainty surrounding the diagnosis, phenotype, prevalence, duration treatment long among children young people (CYP).At time, there was limited evidence suggesting that around 10% infected with SARS-CoV-2 experience prolonged symptoms after initial infection. 1][4] However, longer-term consequences infection CYP were unclear, some reporting ongoing such as fatigue, dyspnoea,...
Adolescence can be defined as a period of biopsychosocial transition from dependent child to an autonomous/independent adult, usually taking place between 13 and 20 years age. There is considerable variation individuals cultures – in some it truncated circumcision. As group adolescents make up 13% the general population, but they probably account for about 30–40% both paediatrician adult physician's workload, especially when dealing with chronic disease limited life span. constitutes large...
Evaluate the experience of virtual consultations for young people and their families assess whether are being offered a confidential space as part these encounters.An anonymous online survey was sent to age 10-18 y.o. who had experienced at least one consultation with an adolescent medicine tertiary service in United Kingdom between March 13th June 2020 mostly associated with, but not exclusively, management chronic fatigue syndrome or medically unexplained symptoms. Responses from were...
Importance Cardiac dysfunction and myocarditis have emerged as serious complications of multisystem inflammatory syndrome in children (MIS-C) vaccines against SARS-CoV-2. Understanding the role autoantibodies these conditions is essential for guiding MIS-C management vaccination strategies children. Objective To investigate presence anticardiac or COVID-19 vaccine-induced myocarditis. Design, Setting, Participants This diagnostic study included with acute vaccine myocarditis, adults...
Abstract Background Some children and young people (CYP) infected with SARS-COV-2 experience impairing symptoms post-infection, known as post-COVID-19 condition (PCC). Using data from the National Long COVID in Children Young People (CloCk) study, we report their impact up to 24-months post-infection. Methods CloCk is a cohort of CYP England aged 11-to-17-years when they had SARS-CoV-2 PCR-test (between September 2020 March 2021). Of 31,012 eligible post-PCR test, 12,632 participated...
Background During the COVID-19 pandemic children and young people (CYP) were socially restricted during a stage of life crucial to development, potentially putting an already vulnerable population at higher risk loneliness, social isolation, poorer wellbeing. The objectives this study are conduct exploratory analysis into loneliness before pandemic, determine which self-reported factors associated with loneliness. Methods findings Participants from Children Long COVID (CLoCk) national...
Objectives Primary objective: to determine the point prevalence and incidence rate of severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in children aged 5–16 years over 13 months. Secondary objectives: describe demographic features, symptoms, impact on activities daily living, school attendance time diagnosis. Design Prospective surveillance study conducted by British Paediatric Surveillance Unit. Paediatricians was asked if they had assessed a child with ME/CFS (screening...