A5103036711- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Adrenal Hormones and Disorders
- Diabetes Management and Research
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Hypothalamic control of reproductive hormones
- Pituitary Gland Disorders and Treatments
- Hormonal and reproductive studies
- Diet and metabolism studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic Syndromes and Imprinting
- Thyroid Disorders and Treatments
- Stress Responses and Cortisol
- Lipid metabolism and disorders
- Ovarian function and disorders
- Childhood Cancer Survivors' Quality of Life
- Metabolism, Diabetes, and Cancer
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Electrolyte and hormonal disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
University College London
2014-2024
University College London Hospitals NHS Foundation Trust
1998-2024
Great Ormond Street Hospital for Children NHS Foundation Trust
2015-2022
Royal London Hospital
2008-2021
Great Ormond Street Hospital
2007-2018
University College Hospital
2000-2018
University Hospital of the West Indies
2018
National and Kapodistrian University of Athens
2015
Institute of Child Health
2000-2014
National Health Service
2003-2011
The feasibility, safety, and efficacy of prolonged use an artificial beta cell (closed-loop insulin-delivery system) in the home setting have not been established.
Background: Glycemic variability has been proposed as a contributing factor in the development of diabetes complications. Multiple measures exist to calculate magnitude glycemic variability, but normative ranges for subjects without have not described. For treatment targets and clinical research we present published variability. Methods: Seventy-eight having fasting plasma glucose <120 mg/dL (6.7 mmol/L) underwent up 72 h continuous monitoring (CGM) with Medtronic Minimed (Northridge, CA)...
Toy choices of 3‐ to 10‐year‐old children with congenital adrenal hyperplasia (CAH) and their unaffected siblings were assessed. Also assessed was parental encouragement sex‐typed toy play. Girls CAH displayed more male‐typical than did sisters, whereas boys without not differ. Mothers fathers encouraged sex‐typical play in CAH. However, girls received positive feedback for girls' toys girls. Data show that increased by cannot be explained Although parents encourage sex‐appropriate behavior,...
OBJECTIVE The mechanisms underlying the association between reduced size at birth and cardiovascular disease non‐insulin‐dependent diabetes mellitus in adult life are not known. One possibility is that intra‐uterine environment has permanent effects on function or activity of hypothalamo‐pituitary‐adrenal axis. We tested this by relating to urinary excretion adrenal androgen glucocorticoid metabolites a population sample 9‐year‐old children. SUBJECTS AND METHODS hundred ninety children (89...
P450 oxidoreductase deficiency (PORD) is a unique congenital adrenal hyperplasia variant that manifests with glucocorticoid deficiency, disordered sex development (DSD), and skeletal malformations. No comprehensive data on genotype-phenotype correlations in Caucasian patients are available.The objective of the study was to establish large PORD cohort.The design clinical, biochemical, genetic assessment including multiplex ligation-dependent probe amplification (MLPA) 30 from 11 countries.We...
Individual variability in human gender-related behaviour is influenced by many factors, including androgen exposure prenatally, as well self-socialization and socialization others postnatally. Many studies have looked at these types of influences isolation, but little known about how they work together. Here, we report that girls exposed to high concentrations androgens because the genetic condition congenital adrenal hyperplasia, show changes processes related behaviour. Specifically, are...
Objective: The objective was to explore psychosocial experiences of closed loop technology for adults, children, and adolescents with type 1 diabetes their parents taking part in two multicenter, free-living, randomized crossover home studies. Methods: Participants using insulin pump therapy were either 12 weeks automated closed-loop glucose control, then sensor augmented (open loop), or vice versa. Closed used 24 hours by adults overnight only children adolescents. completed the Diabetes...
Background There is a marked male preponderance in autism spectrum conditions. The extreme brain theory and the fetal androgen of suggest that elevated prenatal testosterone exposure key contributor to autistic traits. current paper reports findings from two separate studies test this hypothesis. Methods A parent‐report questionnaire, Childhood Autism Spectrum Test ( CAST ), was employed measure traits both studies. first study examined young children with congenital adrenal hyperplasia CAH...
Abstract Aims Hybrid closed‐loop (HCL) systems are characterised by integrating continuous glucose monitoring (CGM) with insulin pumps that automate delivery via specific algorithms and user‐initiated delivery. The aim of the study was to evaluate effectiveness HCLs on HbA1c, time‐in‐range (TIR), hypoglycaemia frequency quality life measures in children young people (CYP) T1D, their carers. Methods Patients were recruited prospectively into National Health Service (NHS) England real‐world...
Abstract Hybrid closed-loop (HCL) systems seamlessly interface continuous glucose monitoring (CGM) with insulin pumps, employing specialised algorithms and user-initiated automated delivery. This study aimed to assess the efficacy of HCLs at 12 months post-initiation on glycated haemoglobin (HbA1c), time-in-range (TIR), hypoglycaemia frequency, quality life measures among children young people (CYP) type 1 diabetes mellitus (T1DM) their caregivers in a real-world setting. Conducted between...
As pituitary function depends on the integrity of hypothalamic-pituitary axis, any defect in development and organogenesis this gland may account for a form combined hormone deficiency (CPHD). Although pit-1 was 1 first factors identified as cause CPHD mice, many other homeodomain transcription have been characterized being involved different developmental stages development, such prophet (prop-1), P-Lim, ETS-1, Brn 4. The aims present study were to screen families patients suffering from...
Abstract Aim As the practice of multiple assessments glucose concentration throughout day increases for people with diabetes, there is a need an assessment glycaemic control weighted clinical risks both hypoglycaemia and hyperglycaemia. Methods We have developed methodology to report degree risk which profile represents. Fifty diabetes professionals assigned values range 40 blood concentrations. Their responses were summarised generic function was derived. This applied patient profiles...
It is estimated that 3-30% of cases with isolated GH deficiency (IGHD) have a genetic etiology, number mutations being reported in GH1 and GHRHR. The aim our study was to genetically characterize cohort patients congenital IGHD analyze their characteristics.A total 224 (190 pedigrees) eutopic posterior pituitary were screened for To explore the possibility an association abnormalities multiple hormone deficiencies, we 62 either deficiencies (42 pedigrees), or ectopic (21 pedigrees).Mutations...
Delayed puberty can be due to either constitutional delay of growth and (CDGP) or hypogonadotropic hypogonadism (HH). Differentiating between the two using current testing difficult. We assessed utility a GnRH test in combination with 3-d 19-d human chorionic gonadotropin (HCG) discriminate conditions.We performed retrospective analysis 43 boys pubertal who required induction testosterone. All were followed through puberty; 29 subsequently diagnosed CDGP 14 HH. A standard (2.5 microg/kg) was...
Summary Objective Recent studies have suggested that mutations in genes encoding several hypothalamo–pituitary (H–P) transcription factors result hypopituitarism [isolated GH deficiency (IGHD) and combined pituitary hormone (CPHD)], which may turn be related to the neuroanatomy revealed by magnetic resonance (MR) imaging. Although focused on patients with either optic nerve hypoplasia (ONH) or isolated normal nerves, few compared two groups. We aimed relate clinical phenotype of a large...
Progress through puberty involves a complex hormonal cascade, but the individual contributions of hormones, particularly IGF-1, are unknown. We reanalysed Chard growth study data to explore tempo based on changes in both height and hormone levels, using novel method curve analysis.Schoolboys (n = 54) girls 70) from Chard, Somerset, England, recruited 1981 at age 8/9 followed 16.Every 6 months, Tanner stages (genitalia, breast, pubic hair) were recorded, subsample (24 boys, 27 girls), blood...
Reports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) of a sufficiently high scientific
Abstract Context Although primary adrenal insufficiency (PAI) in children and young people is often due to congenital hyperplasia (CAH) or autoimmunity, other genetic causes occur. The relative prevalence of these conditions poorly understood. Objective We investigated PAI over a 25 year period. Design, Setting Participants Unpublished published data were reviewed for 155 the United Kingdom who underwent analysis unknown etiology three major research centers between 1993 2018. pre-excluded...
Epidemiological studies suggest that retarded growth in infancy is associated with low adult bone mass. The mechanism underlying this association unknown, but the programming of GH secretion or sensitivity by environmental influences during early development may play a role. We examined issue sample 37 healthy men, aged 63–73 yr, whose weight gain had been recorded. Venous blood samples were obtained under standard conditions every 20 min over 24-h period. Measurements made secretory...