A5027935204- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Disease Management Strategies
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Sleep and related disorders
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Cardiac pacing and defibrillation studies
- COVID-19 and healthcare impacts
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Clinical Research Studies
- Pharmaceutical studies and practices
- Health Promotion and Cardiovascular Prevention
- Heart Failure Treatment and Management
- Pharmacology and Obesity Treatment
- Pharmaceutical Practices and Patient Outcomes
- Health and Lifestyle Studies
- Neuroblastoma Research and Treatments
- Species Distribution and Climate Change
- Sepsis Diagnosis and Treatment
Manchester Academic Health Science Centre
2017-2025
University of Manchester
2017-2025
Manchester Royal Infirmary
2018-2025
Manchester University NHS Foundation Trust
2018-2025
NIHR Manchester Biomedical Research Centre
2023-2024
Diabetes Australia
2022
University of Cambridge
2012-2019
Wellcome/MRC Institute of Metabolic Science
2013-2019
Wellcome Trust
2013-2019
National Health Service
2014-2019
The feasibility, safety, and efficacy of prolonged use an artificial beta cell (closed-loop insulin-delivery system) in the home setting have not been established.
BackgroundThe achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness day-and-night hybrid closed-loop insulin delivery compared sensor-augmented pump therapy in people suboptimally controlled diabetes aged 6 years and older.MethodsIn this open-label, multicentre, multinational, single-period, parallel randomised trial, participants were recruited from outpatient clinics at four hospitals UK two centres USA. randomly assigned...
To compare rates of performing National Institute for Health and Care Excellence-recommended health checks prescribing in people with type 2 diabetes (T2D), before after the first COVID-19 peak March 2020, to assess whether trends varied by age, sex, ethnicity deprivation. We studied 618 161 T2D followed between December 2020 from 1744 UK general practices registered Clinical Practice Research Datalink. focused on six checks: haemoglobin A1c, serum creatinine, cholesterol, urinary albumin...
OBJECTIVE To evaluate feasibility, safety, and efficacy of overnight closed-loop insulin delivery in free-living youth with type 1 diabetes. RESEARCH DESIGN AND METHODS Overnight closed loop was evaluated at home by 16 pump-treated adolescents diabetes aged 12–18 years. Over a 3-week period, directed system, on another period sensor-augmented therapy applied. The order interventions random. primary end point time when adjusted sensor glucose between 3.9 8.0 mmol/L from 2300 to 0700 h....
In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) improve glucose control in type 1 diabetes. We wanted to investigate whether could also 2 diabetes who were receiving noncritical care.In this randomized, open-label trial conducted on general wards two tertiary hospitals located United Kingdom and Switzerland, we assigned 136 adults required...
In persons with type 1 diabetes and high glycated hemoglobin levels, the benefits of intermittently scanned continuous glucose monitoring optional alarms for low blood levels are uncertain.
OBJECTIVE Type 2 diabetes is associated with insulin resistance and skeletal muscle mitochondrial dysfunction. We have found that subjects early-onset type show incapacity to increase Vo2max in response chronic exercise. This suggests a defect Here, we explored the nature of mechanisms involved. RESEARCH DESIGN AND METHODS Muscle biopsies were collected from young diabetic obese control before after acute or exercise protocols, expression genes and/or proteins relevant function was measured....
To explore the experiences of adolescents with type 1 diabetes mellitus (T1DM) and their parents taking part in an overnight closed loop study at home, using qualitative quantitative research methods.
Background Closed-loop insulin delivery is a promising option to improve glycaemic control and reduce the risk of hypoglycaemia.We aimed assess whether overnight home use automated closed-loop would glucose control. MethodsWe did this open-label, multicentre, randomised controlled, crossover study between Dec 1, 2012, 23, 2014, recruiting patients from three centres in UK.Patients aged 18 years or older with type 1 diabetes were randomly assigned receive 4 weeks (using model-predictive...
Continuous glucose monitoring (CGM) enables users to view real-time interstitial readings and provides information on the direction rate of change blood levels. Users can also access historical data inform treatment decisions. While clinical psychological benefits CGM are well established, little is known about how individuals use diabetes self-management. We explored participants' experiences using in order provide recommendations for supporting make optimal this technology. In-depth...
Tight control of blood glucose concentration in people with type 1 diabetes predisposes to hypoglycaemia. We aimed investigate whether day-and-night hybrid closed-loop insulin delivery can improve while alleviating the risk hypoglycaemia adults HbA
OBJECTIVE To evaluate the feasibility of day and night closed-loop insulin delivery in adults with type 1 diabetes under free-living conditions. RESEARCH DESIGN AND METHODS Seventeen on pump therapy (means ± SD age 34 9 years, HbA1c 7.6 0.8%, duration 19 years) participated an open-label multinational three-center crossover study. In a random order, participants underwent two 8-day periods (first at clinical research facility followed by 7 days home) sensor-augmented (SAP) or automated...
Objective: The objective was to explore psychosocial experiences of closed loop technology for adults, children, and adolescents with type 1 diabetes their parents taking part in two multicenter, free-living, randomized crossover home studies. Methods: Participants using insulin pump therapy were either 12 weeks automated closed-loop glucose control, then sensor augmented (open loop), or vice versa. Closed used 24 hours by adults overnight only children adolescents. completed the Diabetes...
Closed-loop (CL) systems modulate insulin delivery according to glucose levels without nurse input. In a prospective randomized controlled trial, we evaluated the feasibility of an automated closed-loop approach based on subcutaneous measurements in comparison with local sliding-scale insulin-therapy protocol.Twenty-four critically ill adults (predominantly trauma and neuroscience patients) hyperglycemia (glucose, ≥10 mM) or already receiving therapy, were receive either fully therapy (model...
OBJECTIVE To evaluate feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions without remote monitoring or supervision. RESEARCH DESIGN AND METHODS In an open-label, randomized, free-living, crossover study design, 12 receiving pump therapy (mean [±SD] age 15.4 ± 2.6 years; HbA1c 8.3 0.9%; duration 8.2 3.4 years) underwent two 7-day periods sensor-augmented supervision monitoring. During the...
We assessed whether fully closed-loop insulin delivery (the so-called artificial pancreas) is safe and effective compared with standard subcutaneous therapy in patients type 2 diabetes the general ward.For this single-centre, open-label, parallel-group, randomised controlled trial, we enrolled aged 18 years or older who were receiving therapy. Patients recruited from wards at Addenbrooke's Hospital, Cambridge, UK. Participants randomly assigned (1:1) by a computer-generated minimisation...
To explore the psychosocial experiences of closed-loop technology and to compare ratings closed- open-loop for adults with Type 1 diabetes taking part in a randomized crossover study.Adults (aged > 18 years) on insulin pump therapy were recruited receive first phase either real-time continuous glucose monitoring overnight or alone (open-loop) followed by second alternative treatment random order, at home 4 weeks, unsupervised. Participants invited share their views semi-structured...
To evaluate the use of hybrid closed-loop glucose control with faster-acting insulin aspart (Fiasp) in adults type 1 diabetes (T1D).