A5031218806- Obesity, Physical Activity, Diet
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Physical Activity and Health
- Child Abuse and Trauma
- Birth, Development, and Health
- Migration, Health and Trauma
- Health disparities and outcomes
- Nutrition and Health in Aging
- Intensive Care Unit Cognitive Disorders
- Nutritional Studies and Diet
- Childhood Cancer Survivors' Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- AI in cancer detection
- Genetic Associations and Epidemiology
- Digital Radiography and Breast Imaging
- Respiratory Support and Mechanisms
- Behavioral Health and Interventions
- Psychosomatic Disorders and Their Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Homelessness and Social Issues
- Employment and Welfare Studies
- Thermal Regulation in Medicine
- Multiple Sclerosis Research Studies
University College London
2016-2025
Faculty (United Kingdom)
2022-2025
English Institute of Sport
2022-2024
Bridge University
2023
MRC Unit for Lifelong Health and Ageing
2018-2022
Great Ormond Street Hospital
2016-2019
Committee on Publication Ethics
2015
MRC Epidemiology Unit
2014
Institute of Cancer Research
2011
Buckinghamshire Healthcare NHS Trust
2011
BackgroundWe describe post-COVID symptomatology in a non-hospitalised, national sample of adolescents aged 11–17 years with PCR-confirmed SARS-CoV-2 infection compared matched negative PCR status.MethodsIn this cohort study, from the Public Health England database who tested positive for between January and March, 2021, were by month test, age, sex, geographical region to negative. 3 months after testing, subsample contacted complete detailed questionnaire, which collected data on...
The aim of this study was to derive a research definition for 'Long COVID (post-COVID-19 condition)' in children and young people (CYP) allow comparisons between studies.A three-phase online Delphi process used, followed by consensus meeting. Participants were presented with 49 statements each phase scored them from 1 9 based on how important they inclusion the Long CYP. meeting held achieve representation across stakeholder groups. Statements agreed at reviewed participants Patient Public...
Abstract Background Childhood abuse is associated with increased adult disease risk, suggesting that processes acting over the long-term, such as epigenetic regulation of gene activity, may be involved. DNA methylation a critical mechanism in regulation. We aimed to establish whether childhood was profiles. Methods In 40 males from 1958 British Birth Cohort we compared genome-wide promoter blood taken at 45y for those with, versus without, (n = 12 vs 28). analysed 20,000 genes and 489...
Background Knowledge of sedentary behaviour associations with health has relied mainly on television-viewing as a proxy and studies other measures are less common. To clarify whether is associated disease-risk, we examined for sitting at work. Methods Using the 1958 British birth cohort (n = 7660), analysed cross-sectional between work (four categories, 0–1 to ≥3 h/d) total, high-density lipoprotein (HDL) low-density (LDL)-cholesterol, triglycerides, blood pressure, glycated haemoglobin,...
<h3>Importance</h3> Associations have been documented between physical activity and depressive symptoms, but the direction of this association is unclear. <h3>Objective</h3> To examine whether symptoms are concurrent with to relationship from 23 50 years age. <h3>Design, Setting, Participants</h3> Participants included members 1958 British Birth Cohort, a general population sample all persons born in England, Scotland, Wales single week March who were followed up age (2008). We approximately...
Adverse childhood experiences (ACEs) have long been known to be related poorer health across the life course. Previous studies typically relied on cumulative risk scores or individual adversities measured through retrospective self-reports. However, these approaches important limitations. Cumulative assume equal weighting of and single adversity approach ignores high probability that co-occur. In contrast, latent class analysis (LCA) offers an alternative operationalise ACEs respects...
Despite high numbers of children and young people (CYP) having acute COVID, there has been no prospective follow-up CYP to establish the pattern health well-being over a year following infection.
Little is known about the prevalence and natural trajectory of post-COVID symptoms in young people, despite very high numbers people having acute COVID. To date, there has been no prospective follow-up to establish pattern over a 6-month time period.A non-hospitalised, national sample 3,395 (1,737 SARS-COV-2 Negative;1,658 Positive at baseline) children (CYP) aged 11-17 completed questionnaires 3 6 months after PCR-confirmed SARS-CoV-2 infection between January March 2021 were compared with...
To describe the physical and mental health of children young people (CYP) 6 months after infection with SARS-CoV-2 explore whether this varies by COVID-19 vaccination.
Background Childhood maltreatment including abuse and neglect has been associated with adult obesity, but evidence on life-course development of obesity or BMI gain is unclear. We aim to establish whether childhood maltreatments are related at different life-stages 7y-50y identify possible explanations for associations. Methods physical, psychological sexual abuse, seven ages were recorded in the 1958 birth cohort (n~15,000). Associations child separate tested using linear regression...
BACKGROUND AND OBJECTIVE: Child maltreatment (abuse and neglect) has established effects on mental health. Less is known about its influence adult economic circumstances. We aimed to establish associations of child with such outcomes explore potential pathways. METHODS: used 1958 British birth cohort data (N = 8076) examine neglect abuse (50 years) long-term sickness absence, not in employment, education or training (NEET), lacking assets, income-related support, poor qualifications,...
Abstract Introduction: We describe post-COVID symptomatology in a national sample of 11-17-year-old children and young people (CYP) with PCR-confirmed SARS-CoV-2 infection compared to test-negative controls. Methods analysis: A cohort study test-positive (n=3,065) age-, sex- geographically-matched CYP (n=3,739) completed detailed questionnaires 3 months post-test. Results : At PCR-testing, 35.4% test-positives 8.3% test-negatives had any symptoms whilst 30.6% 6.2%, respectively, 3+ symptoms....
To describe the prevalence of long COVID in children infected for first time (n = 332) or reinfected 243) with Omicron compared test-negative 311). Overall, 12%-16% those met research definition at 3 and 6 months after infection, no evidence difference between cases positive (Pχ2 0.17).
Abstract Our previous study in children and young people (CYP) at 3- 6-months post-infection showed that 12–16% of those infected with the Omicron (B.1.1.529) variant SARS-CoV-2 met research definition Long Covid, no differences between first-positive reinfected CYP. The primary objective current is to explore impact infection on 12 months post infection. 345 CYP aged 11–17 years a first laboratory-confirmed 360 completed an online questionnaire assessing demographics, symptoms, their...
Abstract Background Findings from studies assessing Long Covid in children and young people (CYP) need to be assessed light of their methodological limitations. For example, if non-response and/or attrition over time systematically differ by sub-groups CYP, findings could biased any generalisation limited. The present study aimed (i) construct survey weights for the Children with (CLoCk) study, (ii) apply them published CLoCk showing prevalence shortness breath tiredness increased baseline...
Background: Although 99% of children and young people have been exposed to SARS-CoV-2, the long-term prevalence post-COVID-19 symptoms in is unclear. The aim this study describe symptom profiles 12 months after SARS-CoV-2 testing. Method: A matched cohort a national sample 20,202 who took PCR test between September 2020 March 2021. Results: post-index-test, there was difference number reported by initial negatives never tested positive (NN) compared other three groups had at least one (p...
Cognitive impairment is often reported after SARS-CoV-2 infection, yet evidence gaps remain. We aimed to (i) report the prevalence and characteristics of children young people (CYP) reporting "brain fog" (i.e., cognitive impairment) 12-months post PCR-proven infection determine whether differences by status exist (ii) explore CYP experiencing over a 12-month period post-infection investigate relationship between poor mental health well-being, fatigue sleep problems.
Objectives Research on associations between childhood maltreatment and adult cardiometabolic disease risk is sparse. We aimed to investigate different forms of child mid-adult markers whether potential intermediaries could account for the observed. Setting 1958 British birth cohort. Participants Approximately 9000 cohort members with data markers. Outcomes Adult (45y) (blood pressure, lipids glycated haemoglobin [HbA 1c ]). Results Seventeen per cent participants were identified as...
BackgroundAn understanding of whether early-life depression is associated with physical multimorbidity could be instrumental for the development preventive measures and integrated management depression. We therefore aimed to map out cumulative incidence over adulthood, determine association between presence depressive symptoms during early adulthood in middle age.MethodsIn this observational cohort study, we used pooled data from 1958 National Child Development Study (NCDS) 1970 British...