Jon Genuneit
A5076790898- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Infant Nutrition and Health
- Breastfeeding Practices and Influences
- Indoor Air Quality and Microbial Exposure
- Occupational exposure and asthma
- Neonatal Respiratory Health Research
- COVID-19 and Mental Health
- Long-Term Effects of COVID-19
- Child Development and Digital Technology
- Infant Health and Development
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Contact Dermatitis and Allergies
- Noise Effects and Management
- Respiratory and Cough-Related Research
- Sleep and related disorders
- Air Quality and Health Impacts
- Eosinophilic Esophagitis
- Maternal Mental Health During Pregnancy and Postpartum
- Chronic Obstructive Pulmonary Disease (COPD) Research
Leipzig University
2019-2025
Universität Ulm
2016-2025
Zimmer Biomet (Germany)
2016-2025
German Center for Pediatric and Adolescent Rheumatology
2025
Université de Lorraine
2024
Institute for Asthma and Allergy
2024
Helmholtz Zentrum München
2024
University Hospital Leipzig
2019-2024
Helmholtz-Institute Ulm
2012-2024
Klinik und Poliklinik für Kinder- und Jugendmedizin
2020-2022
Children who grow up in environments that afford them a wide range of microbial exposures, such as traditional farms, are protected from childhood asthma and atopy. In previous studies, markers exposure have been inversely related to these conditions.
The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess outcomes previously hospitalised with COVID-19 and associated risk factors.This is a prospective cohort (≤18 years old) admitted hospital confirmed COVID-19. Children between 2 April 2020 26 August were included. Telephone interviews used the International Severe Acute Respiratory Emerging Infection Consortium (ISARIC) Health Wellbeing Follow-up Survey for...
Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, specific description of subtypes atopic depending on the timing onset and progression childhood lacking.To identify different phenotypes using definition based symptoms before age 6 years to determine whether some are more at risk for developing other allergic diseases.The Protection Against Allergy Study Rural Environments (PASTURE) European birth cohort where...
The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with and potential risk factors.
A substantial portion of people with COVID-19 subsequently experience lasting symptoms including fatigue, shortness breath, and neurological complaints such as cognitive dysfunction many months after acute infection. Emerging evidence suggests that this condition, commonly referred to long COVID but also known post-acute sequelae SARS-CoV-2 infection (PASC) or post-COVID-19 could become a significant global health burden.While the number studies investigating condition is increasing, there...
Previous studies assessing the prevalence of COVID-19 sequelae in adults and children were performed absence an agreed definition. We investigated post-COVID-19 condition (PCC) (WHO definition), at 6- 12-months follow-up, amongst previously hospitalised assessed risk factors.Prospective cohort study with confirmed Moscow, between April August, 2020. Two follow-up telephone interviews, using International Severe Acute Respiratory Emerging Infection Consortium survey, 6 12 months after...
The coronavirus disease 2019 (COVID-19) pandemic substantially impacted different age groups, with children and young people not exempted. Many have experienced enduring health consequences. Presently, there is no consensus on the outcomes to assess in post-COVID-19 condition. Furthermore, it unclear which measurement instruments are appropriate for use research clinical management of post-COVID-19. To address these unmet needs, we conducted a study, aiming develop core outcome set (COS) an...
Abstract The long-tern implications of stress during university for individuals’ mental health are not well understood so far. Hence, we aimed to examine the potential effect while studying at on depression in later life. We analysed data from two waves longitudinal Study Occupational Allergy Risks. Using ‘work overload’ and ‘proving oneself’ scales Trier Inventory Chronic Stress Patient Health Questionnaire-2 (PHQ-2), participants reported chronic (2007–2009, mean age 22.2 years, T1)...
Abstract In less than half a century, allergy, originally perceived as rare disease, has become major public health threat, today affecting the lives of more 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting budgets systems. More disturbingly, its prevalence impact are on rise, development that been associated with environmental lifestyle changes accompanying continuous process urbanization globalization. Therefore, there is an urgent need...
Clinical and epidemiologic approaches have identified two distinct sets of classifications for asthma wheeze phenotypes.To compare phenotype definitions by latent class analysis (LCA) with clinical phenotypes based on patient histories, diagnostic work-up, treatment responses. To relate to genetic environmental determinants as well treatment-related parameters.LCA was performed in an international multicenter birth cohort yearly questions about current until age 6 years. Associations classes...
Abstract Background Genetic susceptibility and environmental influences are important contributors to the development of asthma atopic diseases. Epigenetic mechanisms may facilitate gene by environment interactions in these Methods We studied rural birth cohort PASTURE (Protection against allergy: study environments) investigate (a) whether epigenetic patterns candidate genes influenced farm exposure general, (b) change over first years life, (c) changes contribute asthma. DNA was extracted...
Rationale: Growing up on a farm protects from childhood asthma and early wheeze. Virus-triggered wheeze in infancy predicts individuals with genetic risk associated chromosome 17q21.Objectives: To test environmental determinants of infections the first year life, potential modifications these associations by 17q21, implications for different trajectories wheeze.Methods: We followed 983 children rural areas Europe birth until age 6 years. Symptoms wheeze, rhinitis, fever, exposures were...
Background The COVID-19 pandemic has potentially had a negative impact on the mental health and well-being of individuals families. Anxiety levels risk factors within particular populations are poorly described. Objective This study aims to evaluate confidence, understanding, trust, concerns, anxiety during in general population assess for increased anxiety. Methods We launched cross-sectional online survey large Russian between April 6 15, 2020, using multiple social media platforms. A set...
Background High microbial diversity in the environment has been associated with lower asthma risk, particularly children exposed to farming. It remains unclear whether this effect operates through an altered microbiome of mucosal surfaces airways. Methods DNA from mattress dust and nasal samples 86 school age was analyzed by 454 pyrosequencing 16S rRNA gene fragments. Based on operational taxonomic units (OTUs), bacterial composition were related farm exposure status. Results Farm positively...