A5069569825- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Intensive Care Unit Cognitive Disorders
- Cerebrospinal fluid and hydrocephalus
- Long-Term Effects of COVID-19
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Vascular Malformations Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Traumatic Brain Injury Research
- Retinal and Optic Conditions
- Inflammatory Biomarkers in Disease Prognosis
- Cerebrovascular and Carotid Artery Diseases
- Retinal Imaging and Analysis
- Moyamoya disease diagnosis and treatment
- Neuroscience and Neuropharmacology Research
The University of Texas Health Science Center at Houston
2015-2025
Columbia University
2020
University of Ulsan
2017
Asan Medical Center
2017
Ulsan College
2017
Abstract Objective The pulvinar nucleus of the thalamus has extensive cortical connections with temporal, parietal, and occipital lobes. Deep brain stimulation (DBS) targeting nucleus, therefore, carries potential for therapeutic benefit in patients drug‐resistant posterior quadrant epilepsy (PQE) neocortical temporal lobe (TLE). Here, we present a single‐center experience managed via bilateral DBS nucleus. Methods A single‐institution retrospective review five who underwent TLE or PQE was...
Abstract BACKGROUND Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies EBI the lack radiographic surrogate marker. OBJECTIVE To propose scoring system based on early changes in clinically obtained computed tomography (CT), called Subarachnoid Brain Edema Score (SEBES). METHODS Patients with spontaneous aneurysmal SAH and CT within 24 h ictus were included. We defined SEBES as scale 0 4 points...
Inflammatory mechanism has been implicated in delayed cerebral ischemia (DCI) and poor functional outcomes after subarachnoid hemorrhage (SAH). Identification of cytokine patterns associated with inflammation acute SAH will provide insights into underlying biological processes DCI that may be amenable to interventions.Serum samples were collected from a prospective cohort 60 patients non-traumatic at four time periods (< 24 h, 24-48 3-5 days, 6-8 days SAH) concentration levels 41 cytokines...
Abstract The gut microbiome is fundamental in neurogenesis processes. Alterations microbial constituents promote inflammation and immunosuppression. Recently, immune-oncology, specific taxa have been described to enhance the effects of therapeutic modalities. However, dysbiosis on glioma are still unknown. aim this study was explore development Temozolomide (TMZ) fecal mice humans. C57BL/6 were implanted with GL261/Sham given TMZ/Saline. Fecal samples collected longitudinally analyzed by 16S...
To determine whether machine learning (ML) algorithms can improve the prediction of delayed cerebral ischemia (DCI) and functional outcomes after subarachnoid hemorrhage (SAH).
Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial (EIM) have been limited. Additionally, male bias in disease severity mortality after evident globally. Sex differences immune response to may mediate this disparity. We investigated BIM, EIM inflammatory cytokine/chemokine (CC) levels across sexes.Plasma samples from 57 subjects at < 48 h hospitalization, 20 matched...
Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage negatively impacts long-term recovery but is often detected too late to prevent damage. We aim develop hourly risk scores using routinely collected clinical data detect DCI.A DCI classification model was trained vital sign measurements (heart rate, blood pressure, respiratory and oxygen saturation) demographics for care. Twenty-two time-varying physiological measures were computed including mean, SD, cross-correlation...
To investigate inflammatory processes after aneurysmal subarachnoid hemorrhage (aSAH) with network models.This is a retrospective observational study of serum samples from 45 participants aSAH analyzed at multiple predetermined time points: <24 hours, 24 to 48 3 5 days, and 6 8 days aSAH. Concentrations cytokines were measured 41-plex human immunoassay kit, the Pearson correlation coefficients between all possible cytokine pairs computed. Systematic models constructed on basis correlations...
ABSTRACT Introduction: Traumatic brain injury (TBI) is associated with secondary to the central nervous system (CNS) via inflammatory mechanisms. The combination of polytrauma and TBI further exacerbates response injury; however, combined phenomena have not been thoroughly studied. In this study, we examined differences between patients versus polytrauma, but no (polytrauma). We hypothesize that a heightened early compared polytrauma. Methods: conducted single-center retrospective study...
Objective: Systemic inflammation after subarachnoid hemorrhage (SAH) is implicated in delayed cerebral ischemia (DCI) and adverse clinical outcomes. We hypothesize that early changes peripheral leukocytes will be associated with outcomes SAH. Methods: SAH patients admitted between January 2009 December 2016 were enrolled into a prospective observational study assessed for Hunt Hess Scale (HHS) at admission, DCI, modified Ranked (mRS) discharge. Total white blood cell (WBC) counts each...
Increased soluble endoglin (sENG) has been observed in human brain arteriovenous malformations (bAVMs). In addition, the overexpression of sENG concurrence with vascular endothelial growth factor (VEGF)-A shown to induce dysplastic vessel formation mouse brains. However, underlying mechanism sENG-induced is not clear. The evidence suggests role as a pro-inflammatory modulator, and increased microglial accumulation inflammation have bAVMs. Therefore, we hypothesized that microglia mediate...
Aneurysmal subarachnoid hemorrhage (aSAH) causes systemic changes that contribute to delayed cerebral ischemia (DCI) and morbidity. Circulating metabolites reflecting underlying pathophysiological mechanisms warrant investigation as biomarker candidates. Blood samples, prospectively collected within 24 hours (T1) of admission 7-days (T2) post ictus, from patients with acute aSAH two tertiary care centers were retrospectively analyzed. Samples healthy subjects non-neurologic critical illness...
INTRODUCTION: Aneurysmal subarachnoid hemorrhage (aSAH) results in significant morbidity and mortality with delayed cerebral ischemia (DCI) contributing to poor outcomes. Pathophysiological mechanisms leading the subacute complication eventual functional deficits are poorly understood. METHODS: Adult subjects aSAH were included. Control consisted of healthy controls from an outpatient clinic hospitalized individuals admitted intensive care unit (ICU). Plasma samples analyzed within 24-hours...
Abstract COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after diagnosis, however there no data available the long-term symptoms. Using prospective registry of hospitalized patients, we assessed assessments (including functional, cognitive and psychiatric assessments) several patients at 3 months. Our main finding that 71% still experienced months most common being fatigue (42%) PTSD (29%). 64% report pain well....
Cerebral edema (CE) at admission is a surrogate marker of 'early brain injury' (EBI) after subarachnoid hemorrhage (SAH). Only recently has the focus on changes in CE SAH such as delayed resolution or newly developed been examined. Among several factors, an early systemic inflammatory response shown to be associated with CE. We investigate markers subjects which does not resolve, i.e., persistent SAH.
Abstract The INSPIRE randomized clinical trial demonstrated that a high protein diet (HPRO) combined with neuromuscular electrical stimulation (NMES) attenuates muscle atrophy and may improve outcomes after aneurysmal subarachnoid hemorrhage We sought to identify specific metabolites mediating these effects. Blood samples were collected from subjects on admission prior randomization either standard of care (SOC; N = 12) or HPRO + NMES (N at 7 days. Untargeted metabolomics performed for each...
Background Subarachnoid hemorrhage (SAH) causes life-long neurologic dysfunctions. Peripheral inflammatory processes as a reaction to brain injury has been shown worsen outcomes after SAH. Galantamine reduce proinflammatory microglial activities and improve synaptic connections. We hypothesize that galantamine treatment SAH mitigates inflammation-mediated neuronal outcomes. conducted pilot clinical trial examine the tolerability safety of in patients. Methods This prospective, multicenter,...
Mild traumatic brain injury (mTBI) accounts for 70-90% of all TBI cases. Lipid metabolites have important roles in plasma membrane biogenesis, function, and cell signaling. As can compromise integrity alter we sought to identify circulating phospholipid alterations after mTBI, determine if these changes were associated with clinical outcomes. Patients mTBI (Glasgow Coma Score [GCS] ≥13 loss consciousness <30 min) recruited. A total 84 subjects enrolled admission a level I trauma center, the...
Study Objective To assess whether a positive linear association exists between body mass index (BMI) and incidence of venous thromboembolism (VTE) in overweight obese hospitalized patients. Design Single‐center retrospective observational cohort study. Setting Large academic tertiary care medical center. Patients A total 1452 adults January 1, 2013, December 31, 2014, who weighed more than 100 kg had BMI 25 kg/m 2 or greater on admission, received heparin subcutaneously for VTE prophylaxis....