A5100661680- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Antiplatelet Therapy and Cardiovascular Diseases
- Thermal Regulation in Medicine
- Venous Thromboembolism Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Parkinson's Disease and Spinal Disorders
- Stroke Rehabilitation and Recovery
- Takotsubo Cardiomyopathy and Associated Phenomena
- Long-Term Effects of COVID-19
- Electrolyte and hormonal disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury Research
- Orthopedic Infections and Treatments
- S100 Proteins and Annexins
- Respiratory Support and Mechanisms
Morristown Medical Center
2025
Atlantic Health System
2025
University of Michigan
1982-2025
Rutgers, The State University of New Jersey
2017-2023
Ulsan College
2011-2023
Gangneung Asan Hospital
2006-2023
University of Ulsan
2011-2023
Johnson University
2018-2023
Columbia University
2007-2022
Robert Wood Johnson University Hospital
2017-2022
Abstract Introduction Subarachnoid hemorrhage (SAH) is a devastating form of stroke. Causes and mechanisms in-hospital death after SAH in the modern era neurocritical care remain incompletely understood. Methods We studied 1200 consecutive patients prospectively enrolled Columbia University Outcomes Project between July 1996 January 2009. Analysis was performed to identify predictors mortality. Results In-hospital mortality 18 % (216/1200): 3 for Hunt-Hess grade 1 or 2, 9 3, 24 4, 71 5. The...
To obtain an estimate of how often practicing neurologists in California encounter unexpected strokes, myelopathies, or radiculopathies following chiropractic manipulation, we surveyed each member the American Academy Neurology and inquired about number patients evaluated over preceding 2 years who suffered a neurologic complication within 24 hours manipulation. Four hundred eighty-six were surveyed, 177 responded; 55 16 30 reported. Patients between ages 21 60, majority experienced...
OBJECTIVE Transcranial Doppler (TCD) is widely used to monitor the temporal course of vasospasm after subarachnoid hemorrhage (SAH), but its ability predict clinical deterioration or infarction from delayed cerebral ischemia (DCI) remains controversial. We sought determine prognostic utility serial TCD examination SAH. METHODS analyzed 1877 examinations in 441 aneurysmal SAH patients within 14 days onset. The highest mean blood flow velocity (mBFV) value any vessel before DCI onset was...
Abstract BACKGROUND Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies EBI the lack radiographic surrogate marker. OBJECTIVE To propose scoring system based on early changes in clinically obtained computed tomography (CT), called Subarachnoid Brain Edema Score (SEBES). METHODS Patients with spontaneous aneurysmal SAH and CT within 24 h ictus were included. We defined SEBES as scale 0 4 points...
Background and Purpose— To identify a minimally acceptable cerebral perfusion pressure threshold above which the risks of brain tissue hypoxia (BTH) oxidative metabolic crisis are reduced for patients with subarachnoid hemorrhage (SAH). Methods— We studied 30 poor-grade SAH who underwent multimodality monitoring (3042 hours). Physiological measures were averaged over 60 minutes each collected microdialysis sample. Metabolic was defined as lactate/pyruvate ratio >40 glucose concentration...
Therapeutic hypothermia improves outcomes in experimental stroke models, especially after ischemia-reperfusion injury. We investigated the clinical and radiological effects of therapeutic acute ischemic patients recanalization.A prospective cohort study at 2 centers was performed. enrolled with anterior circulation an initial National Institutes Health Stroke Scale≥10 who had successful recanalization (≥thrombolysis cerebral ischemia, 2b). Patients center A underwent a mild (34.5°C)...
Abstract Introduction Daily interruption of sedation (IS) has been implemented in 30 to 40% intensive care units worldwide and may improve outcome medical patients. Little is known about the benefit IS acutely brain-injured Methods This prospective observational study was performed a neuroscience unit tertiary-care academic center. Twenty consecutive severely patients with multimodal neuromonitoring were analyzed for levels brain lactate, pyruvate glucose, intracranial pressure (ICP),...
Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic resonance imaging of stroke patients. We investigated how hyperintensity volumes affect outcomes, generally and by subtype. In total, 5035 acute ischaemic patients were enrolled. Strokes classified as large artery atherosclerosis, small vessel occlusion, cardioembolism. White stratified into quintiles. Mean age (± standard deviation) was 66.3 ± 12.8, 59.6% male. Median (interquartile range) modified Rankin...
<h3>Introduction</h3> It is still unknown whether subsequent perihaematomal oedema (PHE) formation further increases the odds of an unfavourable outcome. <h3>Methods</h3> Demographic, clinical, radiographic and outcome data were prospectively collected in a single large academic centre. A multiple logistic regression model was then developed to determine effect admission volume on <h3>Results</h3> 133 patients analysed this study. While there no significant association between relative PHE...
Introduction Takotsubo Cardiomyopathy (TCM) is a rare but well recognized complication of subarachnoid hemorrhage associated with increased morbidity and poor clinical outcomes. There scarcity literature describing the prevalence risk factors this complication. The aim study was to identify patients who are at developing TCM in non-traumatic hemorrhage. Methods 2016 2021 National Inpatient Sample (NIS) used adult inpatients primary diagnosis Univariate multivariable analyses adjusting for...
Object The purpose of this study was to identify predictors shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage (SAH). Methods authors evaluated the incidence in a consecutive cohort 580 patients with SAH who were admitted Neurological Intensive Care Unit Columbia University Medical Center between July 1996 and September 2002. Patient demographics, 24-hour admission variables, initial CT scan characteristics, daily transcranial Doppler development in-hospital complications...
Background and Purpose— Delayed cerebral ischemia (DCI) is an important complication after subarachnoid hemorrhage appears to be associated with clot burden on CT. Quantification of digitized images may a more accurate method for predicting DCI than qualitative scales. Methods— Quantitative analysis CT was performed in 160 patients who were scanned within 24 hours from the symptom onset between June 25, 2005 July 19, 2009. Cisternal plus intraventricular volumes (CIHV) classified into...
Fever during the first week after subarachnoid hemorrhage (SAH) is associated with poor outcome; however, eliminating fever has not been shown to improve outcome. We sought explore potential impact of induced normothermia using advanced control (AFC) methods on outcome SAH.We identified 40 consecutive febrile patients enrolled in Columbia University SAH Outcomes Project between 2003 and 2005 who underwent AFC (37 degrees C) a surface cooling device 14 days randomly matched by age, Hunt Hess...
To determine the association between exposure to hyperoxia and risk of delayed cerebral ischaemia (DCI) after subarachnoid haemorrhage (SAH).We analysed data from a single centre, prospective, observational cohort database. Patient inclusion criteria were age ≥18 years, aneurysmal SAH, endotracheal intubation with mechanical ventilation, arterial partial pressure oxygen (PaO2) measurements. Hyperoxia was defined as highest quartile an area under curve PaO2, until development DCI (PaO2≥173 mm...
Cerebral glucose metabolism and energy production are affected by serum levels. Systemic variability has been shown to be associated with poor outcome in critically ill patients. The objective of this study was assess whether is cerebral metabolic distress after subarachnoid hemorrhage. A total 28 consecutive comatose patients hemorrhage, who underwent microdialysis intracranial pressure monitoring, were studied. Metabolic defined as lactate/pyruvate ratio (LPR) >40. relationship between...
Two mRNA COVID-19 vaccines (mRNA-1273, Moderna; and BNT162b2, Pfizer-BioNTech) one viral vector vaccine (JNJ-78436735, Janssen/Johnson Johnson) are authorized in the US to hinder infections. We analyzed severe common adverse events response using real-world, Vaccine Adverse Effect Reporting System (VAERS) data. From 14 December 2020 30 September 2021, 481,172 (50.7 ± 17.5 years, males 27.89%, 12.35 per 100,000 people) individuals reported (AEs). The median time AEs was 2 days after...