A5029043796- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Menopause: Health Impacts and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrospinal fluid and hydrocephalus
- Estrogen and related hormone effects
- Glioma Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- History of Medical Practice
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Muscle metabolism and nutrition
- Aortic aneurysm repair treatments
- Thermoregulation and physiological responses
- Neurological Disease Mechanisms and Treatments
- Surgical Simulation and Training
The University of Texas Health Science Center at Houston
2015-2025
University of Illinois Urbana-Champaign
2025
Harvard University
2005-2022
Memorial Hermann–Texas Medical Center
2022
Brigham and Women's Hospital
2002-2022
Autism Speaks
2022
Albany Medical Center Hospital
2022
Myongji Hospital
2022
Neurological Surgery
1986-2021
Stanford University
2021
The present study was undertaken to determine if estrogens protect female rats from the neurodegenerative effects of middle cerebral artery (MCA) occlusion. were ovariectomized and 7 or 8 days later various estrogen preparations administered before after MCA Pretreatment with 17beta-estradiol (17beta-E2) a brain-targeted 17beta-E2 chemical delivery system (CDS) decreased mortality 65% in 22% 17beta-E2-treated 16% CDS-treated rats. This marked reduction accompanied by ischemic area brain...
A 39-year-old man developed retrograde and anterograde amnesia following haemorrhage from an arteriovenous malformation situated near the splenium of corpus callosum. MRI studies demonstrated damage to splenium, a region containing retrosplenial cortex cingulate bundle. The fornix was anterior inferior site maximal damage, but may have been involved; stria terminalis probably spared. Structures known be important in memory spared by lesion included hippocampus, thalamus, basal forebrain....
✓ The clinical, radiographic, and anatomical features in 80 patients with ophthalmic segment aneurysms were reviewed, categorized according to a presumed origin related the (41 cases) or superior hypophyseal (39 arteries. There was marked female predominance (7:1) high incidence of multiple (45%) within this population. Clinical presentations included subarachnoid hemorrhage 23 cases (29%) visual deficits 24 (30%); five exhibited both loss. Twenty-eight incidentally identified. Ophthalmic...
Green’s View that the Kilauea Emanation is Anhydrous In a book, 1 now little known and rare, William Lowthian Green, distinguished Englishman, long in service of native government Hawaiian Islands, writes as follows : “What we mainly wish to contend for Impress upon geologists—for re-consideration, at least—is, it may be mistake assert, so often done most positive manner water steam are inseparably connected with volcanic action. On contrary would appear elastic vapors have nothing do...
Background and Purpose —17β-Estradiol (E2) has been reported to exert neuroprotective effects when administered before an ischemic insult. This study was designed determine whether E2 treatment after ischemia exerts the same and, if so, how long this therapeutic window remains open, are related changes in cerebral blood flow (CBF). Methods —Female Sprague-Dawley rats were subjected permanent middle artery occlusion (MCAO). In protocol 1, (100 μg/kg IV followed immediately by subcutaneous...
✓ The clinical and anatomical features of 21 surgically treated saccular aneurysms the posterior inferior cerebellar artery (PICA) are analyzed. Seventeen these lesions originated from PICA-vertebral junction, four arose distal PICA branching sites. Twelve left PICA, nine were right-sided, all small (less than 12.5 mm). Most occurred in females (16 21) presented as classic subarachnoid hemorrhage. lack specific focal deficits prevented an accurate pre-angiographic determination aneurysm...
Aneurysms located on the distal portion of posterior inferior cerebellar artery (PICA) are uncommon, and their underlying pathology, natural history, clinical management poorly understood. To clarify these lesions more fully, authors undertook a retrospective analysis features results 22 PICA aneurysms in 20 consecutive patients treated at one institution by same surgeon during past decade.The series included 10 men women (mean age presentation 51 years). Nine presented with only...
A prospective multi-institutional study was carried out to evaluate automated percutaneous discectomy in the treatment of lumbar disc herniations. Of 327 patients who prospectively met criteria and were followed for longer than 1 year, 75.2% successfully treated. When (n = 168) did not meet treated, success rate 49.4%. One case discitis reported; otherwise, no other serious complications noted, specifically vascular or nerve damage encountered. This indicates that can be used treat...
Abstract BACKGROUND Early brain injury (EBI) after subarachnoid hemorrhage (SAH) is an important determinant of clinical outcomes. However, a major hindrance to studies EBI the lack radiographic surrogate marker. OBJECTIVE To propose scoring system based on early changes in clinically obtained computed tomography (CT), called Subarachnoid Brain Edema Score (SEBES). METHODS Patients with spontaneous aneurysmal SAH and CT within 24 h ictus were included. We defined SEBES as scale 0 4 points...
Background and Purpose— The identification of a neuroprotective drug for stroke remains elusive. Given that mitochondria play key role both in maintaining cellular energetic homeostasis triggering the activation cell death pathways, we evaluated efficacy newly identified inhibitors cytochrome c release hypoxia/ischemia induced death. We demonstrate methazolamide melatonin are protective vivo models neuronal hypoxia. Methods— effects were tested oxygen/glucose deprivation–induced primary...
Genetic risk factors for intracranial aneurysm (IA) are not yet fully understood. Genomewide association studies have been successful at identifying common variants; however, the role of rare variation in IA susceptibility has explored. In this study, we report use whole exome sequencing (WES) seven densely-affected families (45 individuals) recruited as part Familial Intracranial Aneurysm study. WES variants were prioritized by functional prediction, frequency, predicted pathogenicity, and...
Time elapsed from last-known well (LKW) and baseline imaging results are influential on endovascular thrombectomy (EVT) outcomes.In a prospective multicenter cohort study of selection for (SELECT [Optimizing Patient's Selection Endovascular Treatment in Acute Ischemic Stroke], the early infarct growth rate (EIGR) was defined as ischemic core volume perfusion (relative cerebral blood flow<30%) divided by time LKW to imaging. The optimal EIGR cutoff identified maximizing sum sensitivity...
Patients with large ischemic core stroke have poor clinical outcomes and are frequently not considered for interfacility transfer endovascular thrombectomy (EVT).