Morris A. Swertz
A5052368642- Genetic Associations and Epidemiology
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Scientific Computing and Data Management
- Research Data Management Practices
- Gene expression and cancer classification
- Biomedical Text Mining and Ontologies
- Bioinformatics and Genomic Networks
- Genomic variations and chromosomal abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Health, Environment, Cognitive Aging
- Genetic and phenotypic traits in livestock
- Semantic Web and Ontologies
- Diet and metabolism studies
- Birth, Development, and Health
- Data Quality and Management
- Nutritional Studies and Diet
- Gut microbiota and health
- RNA modifications and cancer
- Metabolomics and Mass Spectrometry Studies
- Ethics in Clinical Research
- Distributed and Parallel Computing Systems
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Leiden University Medical Center
2016-2024
Institut thématique Génétique, génomique et bioinformatique
2018-2023
Radboud University Nijmegen
2011-2023
Radboud University Medical Center
2011-2023
Vrije Universiteit Amsterdam
2023
Amsterdam University Medical Centers
2023
Queen's University Belfast
2022
Biobanking and BioMolecular resources Research Infrastructure The Netherlands
2012-2020
There is an urgent need to improve the infrastructure supporting reuse of scholarly data. A diverse set stakeholders-representing academia, industry, funding agencies, and publishers-have come together design jointly endorse a concise measureable principles that we refer as FAIR Data Principles. The intent these may act guideline for those wishing enhance reusability their data holdings. Distinct from peer initiatives focus on human scholar, Principles put specific emphasis enhancing ability...
“Normal” for the gut microbiota For benefit of future clinical studies, it is critical to establish what constitutes a “normal” microbiome, if exists at all. Through fecal samples and questionnaires, Falony et al. Zhernakova targeted general populations in Belgium Netherlands, respectively. Gut composition correlated with range factors including diet, use medication, red blood cell counts, chromogranin A, stool consistency. The data give some hints possible biomarkers normal communities....
The LifeLines Cohort Study is a large population-based cohort study and biobank that was established as resource for research on complex interactions between environmental, phenotypic genomic factors in the development of chronic diseases healthy ageing. Between 2006 2013, inhabitants northern part Netherlands their families were invited to participate, thereby contributing three-generation design. Participants visited one sites physical examination, including lung function, ECG cognition...
Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several large-scale cohort studies. Aim this study was describe prevalence obesity, syndrome (MetS) metabolically healthy (MHO) in ten participating studies.Ten different cohorts seven countries were combined,...
Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individuals the eQTLGen Consortium. We observed that cis -eQTLs can be detected for 88% of studied genes, but they a different genetic architecture compared to variants, limiting our ability use pinpoint...
Differences in gut microbiota composition and function were observed between patients with inflammatory bowel disease or irritable syndrome.
Abstract The methylome is subject to genetic and environmental effects. Their impact may depend on sex age, resulting in sex- age-related physiological variation disease susceptibility. Here we estimate the total heritability of DNA methylation levels whole blood variance explained by common single nucleotide polymorphisms at 411,169 sites 2,603 individuals from twin families, establish a catalogue between-individual methylation. Heritability estimates vary across genome (mean=19%)...
The recent proliferation of high-resolution mass spectrometers has generated a wealth new data analysis methods. However, flexible integration these methods into configurations best suited to the research question is hampered by heterogeneous file formats and monolithic software development. mzXML, mzData, mzML have enabled uniform access unprocessed raw data. In this paper we present our efforts produce an equally simple powerful format, PeakML, uniformly exchange processed intermediary...
Within the Netherlands a national network of biobanks has been established (Biobanking and Biomolecular Research Infrastructure-Netherlands (BBMRI-NL)) as node European BBMRI. One aims BBMRI-NL is to enrich with different types molecular phenotype data. Here, we describe Genome (GoNL), one projects within BBMRI-NL. GoNL whole-genome-sequencing project in representative sample consisting 250 trio-families from all provinces Netherlands, which characterize DNA sequence variation Dutch...
There is a critical need for population-based prospective cohort studies because they follow individuals before the onset of disease, allowing that can identify biomarkers and disease-modifying effects, thereby contributing to systems epidemiology.This paper describes design baseline characteristics an intensively examined subpopulation LifeLines in Netherlands. In this unique subcohort, DEEP, we included 1539 participants aged 18 years older.We collected additional blood (n = 1387), exhaled...