A5100666789- Inflammatory Bowel Disease
- Transplantation: Methods and Outcomes
- Genetic Associations and Epidemiology
- Microscopic Colitis
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Organ Transplantation Techniques and Outcomes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Hemoglobin structure and function
- Protein Structure and Dynamics
- Eosinophilic Esophagitis
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- Cancer-related molecular mechanisms research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Blood Pressure and Hypertension Studies
- Immunotherapy and Immune Responses
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Mechanical Circulatory Support Devices
- Bacterial Genetics and Biotechnology
- Cleft Lip and Palate Research
- Metabolism, Diabetes, and Cancer
University of Cambridge
2014-2025
Twin Cities Orthopedics
2024-2025
University of Minnesota
2018-2025
The Royal Free Hospital
2022-2025
University College London
2022-2025
The Francis Crick Institute
2021-2025
University of Oxford
2023-2025
Henry Ford Health System
2019-2025
MRC Epidemiology Unit
2022-2025
Kaiser Permanente
2024
Interleukin-8 (IL-8) is a member of family pro-inflammatory cytokines. Although the best characterized activities IL-8 include chemoattraction and activation neutrophils, other members this have wide range specific actions including chemotaxis monocytes, selective memory T cells, inhibition hematopoietic stem cell proliferation, induction neutrophil infiltration in vivo. A complementary DNA encoding receptor from human neutrophils has now been isolated. The amino acid sequence shows that...
The interactions between proteins and solvent components have been investigated for the sucrose/water system. Thermodynamic kinetic measurements of thermal unfolding alpha-chymotrypsin, chymotrypsinogen, ribonuclease were performed as a function sucrose concentration. alteration in protein-solvent presence was also studied by density analyzed multicomponent thermodynamic theory. Sucrose does not induce conformational change three studied, although it small circular dichroism spectrum...
The proto-oncogene designated erb B2 or HER2 encodes a 185-kilodalton transmembrane tyrosine kinase (p185 ), whose overexpression has been correlated with poor prognosis in several human malignancies. A 45-kilodalton protein heregulin-α (HRG-α) that specifically induced phosphorylation of p185 was purified from the conditioned medium breast tumor cell line. Several complementary DNA clones encoding related HRGs were identified, all which are similar to proteins epidermal growth factor...
Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies identified 163 susceptibility loci for disease, mostly shared between colitis. We undertook largest genotype association study, to date, in widely used clinical subphenotypes with goal further understanding biological relations diseases.
Interleukin-8 (IL-8) is a proinflammatory cytokine that specifically attracts and activates human neutrophils. A murine gene with high degree of homology to the two known IL-8 receptors was cloned then deleted from mouse genome by homologous recombination in embryonic stem (ES) cells. These mice, although outwardly healthy, had lymphadenopathy, resulting an increase B cells, splenomegaly, metamyelocytes, band, mature Thus, this receptor may participate expansion development neutrophils This...
Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.We sought to identify donor, recipient, perioperative factors PGD.We performed a 10-center prospective cohort study enrolled between March 2002 December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society Heart Transplantation grade 3 at 48 or 72 hours post-transplant....
We report identification of interleukin (IL)-17E, a novel member the IL-17 family cytokines. IL-17E is ligand for recently identified protein termed EVI27/IL-17BR, which we term receptor homolog 1 (IL-17Rh1) in light multiple reported ligand-receptor relationships. Murine EVI27 was through its location at common site retroviral integration BXH2 murine myeloid leukemias. IL-17Rh1 shows highest level expression kidney with moderate other organs, whereas mRNA detected very low levels several...
The interferon-inducible transmembrane (IFITM) protein family represents a new class of cellular restriction factors that block early stages viral replication; the underlying mechanism is currently not known. Here we provide evidence IFITM proteins restrict membrane fusion induced by representatives all three classes proteins. IFITM1 profoundly suppressed syncytia formation and cell-cell almost examined; IFITM2 IFITM3 also strongly inhibited their fusion, with efficiency somewhat dependent...
ADVERTISEMENT RETURN TO ISSUEPREVArticleIn vitro reconstitution of calf brain microtubules: effects solution variablesJames C. Lee and Serge N. TimasheffCite this: Biochemistry 1977, 16, 8, 1754–1764Publication Date (Print):April 19, 1977Publication History Published online1 May 2002Published inissue 19 April 1977https://pubs.acs.org/doi/10.1021/bi00627a037https://doi.org/10.1021/bi00627a037research-articleACS PublicationsRequest reuse permissionsArticle Views514Altmetric-Citations232LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPartial specific volumes and interactions with solvent components of proteins in guanidine hydrochlorideJames C. Lee Serge N. TimasheffCite this: Biochemistry 1974, 13, 2, 257–265Publication Date (Print):January 15, 1974Publication History Published online1 May 2002Published inissue 15 January 1974https://doi.org/10.1021/bi00699a005RIGHTS & PERMISSIONSArticle Views741Altmetric-Citations290LEARN ABOUT THESE METRICSArticle Views are the...
Crohn disease (CD) and ulcerative colitis (UC) are increasingly common, chronic forms of inflammatory bowel disease. The behavior these diseases varies unpredictably among patients. Identification reliable prognostic biomarkers would enable treatment to be personalized so that patients destined experience aggressive could receive appropriately potent therapies from diagnosis, while those who will more indolent not exposed the risks side effects unnecessary immunosuppression. Using...