A5086233693- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Intensive Care Unit Cognitive Disorders
- Neonatal Respiratory Health Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Polyomavirus and related diseases
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Pulmonary Hypertension Research and Treatments
- Organ and Tissue Transplantation Research
- Tracheal and airway disorders
- Viral Infections and Immunology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Respiratory viral infections research
- Family and Patient Care in Intensive Care Units
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
University of Pennsylvania
2016-2025
Penn Center for AIDS Research
2019-2024
Hospital of the University of Pennsylvania
2014-2024
California University of Pennsylvania
2012-2024
KU Leuven
2024
Newcastle University
2024
Pulmonary Associates
2023-2024
National Heart Lung and Blood Institute
2008-2024
Pulmonary and Allergy Associates
2012-2023
International Society for Heart and Lung Transplantation
2007-2023
Translational studies in liver transplantation often require an endpoint of graft function or dysfunction beyond loss. Prior definitions early allograft (EAD) vary, and none have been validated a large multicenter population the Model for End-Stage Liver Disease (MELD) era. We examined updated definition EAD to validate previously used criteria, correlated this with patient outcome. performed cohort study 300 deceased donor transplants at 3 U.S. programs. was defined as presence one more...
Principle: Serum lactate is a potentially useful biomarker to risk-stratify patients with severe sepsis; however, it plausible that elevated serum simply manifestation of clinically apparent organ dysfunction and/or shock (i.e., refractory hypotension). Objective: To test whether the association between initial level and mortality in presenting emergency department (ED) sepsis independent shock. Design: Single-center cohort study. The primary outcome was 28-day risk factor variable venous...
Doppler echocardiography is commonly used to estimate systolic pulmonary artery pressure and diagnose hypertension, but data relating its utility in patients with advanced lung disease are limited. In a cohort study of 374 transplant candidates, the performance characteristics compared right heart catheterization determination diagnosis hypertension were investigated. The prevalence was 25% population. Estimation by possible 166 (44%). correlation between estimated measured cardiac good (r =...
Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.We sought to identify donor, recipient, perioperative factors PGD.We performed a 10-center prospective cohort study enrolled between March 2002 December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society Heart Transplantation grade 3 at 48 or 72 hours post-transplant....
Renin-angiotensin system (RAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of acute respiratory distress syndrome (ARDS). We postulated that repleting ACE2 using GSK2586881, a recombinant form human (rhACE2), could attenuate lung injury. conducted two-part phase II trial comprising an open-label intrapatient dose escalation randomized, double-blind, placebo-controlled ten intensive care units North America. Patients were between ages 18 80...
Cognitive and psychiatric morbidity is common potentially modifiable after acute lung injury (ALI). However, practical measures of neuropsychological function for use in multicenter trials are lacking.
Despite advances in clinical management, there are currently no reliable diagnostic and therapeutic targets for acute respiratory distress syndrome (ARDS). The inflammasome/caspase-1 pathway regulates the maturation secretion of proinflammatory cytokines (e.g., IL-18). IL-18 is associated with injury animal models systemic inflammation.We sought to determine contribution inflammasome experimental lung human ARDS.We performed comprehensive gene expression profiling on peripheral blood from...
Mitochondrial DNA (mtDNA) is a critical activator of inflammation and the innate immune system. However, mtDNA level has not been tested for its role as biomarker in intensive care unit (ICU). We hypothesized that circulating cell-free levels would be associated with mortality improve risk prediction ICU patients.Analyses were performed on blood samples obtained from two prospective observational cohort studies patients (the Brigham Women's Hospital Registry Critical Illness [BWH RoCI, n =...