A5078708353- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Heart Disease Studies
- Cardiac pacing and defibrillation studies
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Foot and Ankle Surgery
- Cardiovascular Function and Risk Factors
- Organ Donation and Transplantation
- Heart Failure Treatment and Management
- Cardiac and Coronary Surgery Techniques
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Hepatitis C virus research
- Aortic Disease and Treatment Approaches
- Intensive Care Unit Cognitive Disorders
- Polyomavirus and related diseases
- Orthopedic Surgery and Rehabilitation
Vanderbilt University
2016-2025
University of Alabama at Birmingham
2022-2025
Vanderbilt University Medical Center
2016-2025
Vanderbilt Health
2016-2024
University of Manitoba
2022-2024
Suamandeep Vidyapeeth University
2024
St. Boniface Hospital
2023-2024
Willis-Knighton Cancer Center
2024
Medical College of Wisconsin
2023
Charlottesville Medical Research
2023
Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors.We sought to identify donor, recipient, perioperative factors PGD.We performed a 10-center prospective cohort study enrolled between March 2002 December 2010 (the Lung Transplant Outcomes Group). The primary outcome was International Society Heart Transplantation grade 3 at 48 or 72 hours post-transplant....
Although accumulating data support the efficacy of intramyocardial cell-based therapy to improve left ventricular (LV) function in patients with chronic ischemic cardiomyopathy undergoing CABG, underlying mechanism and impact cell injection site remain controversial. Mesenchymal stem cells (MSCs) LV structure through several effects including reducing fibrosis, neoangiogenesis, neomyogenesis.To test hypothesis that on cardiac after injections autologous MSCs results from a concordance...
Data showing the efficacy and safety of transplantation hearts obtained from donors after circulatory death as compared with brain are limited. Download a PDF Research Summary. We conducted randomized, noninferiority trial in which adult candidates for heart were assigned 3:1 ratio to receive donor or if that was available first (circulatory-death group) only had been preserved use traditional cold storage (brain-death group). The primary end point risk-adjusted survival at 6 months...
BackgroundHeart transplantation is an effective treatment offering the best recovery in both quality and quantity of life those affected by refractory, severe heart failure. However, limited donor organ availability. The reintroduction donation after circulatory determination death (DCD) 2014 offered uplift transplant activity 30%. Thoraco-abdominal normothermic regional perfusion (taNRP) enables in-situ reperfusion DCD heart. objective this paper to assess clinical outcomes hearts recovered...
Exogenous gene delivery to alter the function of heart is a potential novel therapeutic strategy for treatment cardiovascular diseases such as failure (HF). Before therapy approaches cardiac can be realized, efficient and reproducible in vivo techniques must established efficiently transfer transgenes globally myocardium. We have been testing hypothesis that genetic manipulation myocardial β-adrenergic receptor (β-AR) system, which impaired HF, enhance function. delivered adenoviral...
When the heart fails, there is often a constellation of biochemical alterations β-adrenergic receptor (βAR) signaling system, leading to loss cardiac inotropic reserve. βAR down-regulation and functional uncoupling are mediated through enhanced activity kinase (βARK1), expression which increased in ischemic failing myocardium. These changes widely viewed as representing an adaptive mechanism, protects against chronic activation. In this study, we demonstrate, using vivo intracoronary...
Background —Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed determine the feasibility and functional consequences of in vivo β-adrenergic receptor kinase (βARK1) inhibition a model chronic left ventricular (LV) dysfunction after myocardial infarction (MI). Methods Results —Rabbits underwent ligation circumflex (LCx) marginal artery implantation sonomicrometric crystals. Baseline cardiac physiology...
Pulmonary hypertension (PH) secondary to left heart failure portends a poor prognosis and is relative contraindication transplantation at many centers. We tested the hypothesis that when PH persists after adequate ventricle unloading via recent ventricular assist device (LVAD) therapy, phosphodiesterase type 5A inhibition would decrease in this population.We performed an open-label clinical trial using control patients not receiving therapy. Between 1999 2007, 138 consecutive undergoing...
Introduction— Single-institution series have suggested that men receiving orthotopic heart transplantation from female donors decreased survival. No multi-institutional has comprehensively addressed the issue of donor and recipient sex matching for both male recipients. Methods Results— We used data prospectively collected United Network Organ Sharing open cohort to review 18 240 adult patients who received 1999 2007. Four strata were identified (male donor/male recipient, N=10 750;...
<h3>Importance</h3> Delirium occurs in up to 52% of patients after cardiac surgery and may result from changes cerebral perfusion. Using intraoperative autoregulation monitoring individualize optimize perfusion be a useful strategy reduce the incidence delirium surgery. <h3>Objective</h3> To determine whether targeting mean arterial pressure during cardiopulmonary bypass (CPB) using reduces compared with usual care. <h3>Design, Setting, Participants</h3> This randomized clinical trial nested...
An increasing number of patients older than 65 years are referred for and have access to organ transplantation, an adults donating organs. Although short-term outcomes similar in versus younger transplant recipients, donor or recipient age is associated with inferior long-term outcomes. However, often a proxy other factors that might predict poor more strongly better identify at risk adverse events. Approaches transplantation vary across programs, but despite recent gains the increased use...