Axel Unbehaun
A5055058077- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac, Anesthesia and Surgical Outcomes
- Heart Rate Variability and Autonomic Control
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Vascular Procedures and Complications
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Cardiovascular and Diving-Related Complications
- Infant Health and Development
- Non-Invasive Vital Sign Monitoring
- Neuroscience of respiration and sleep
- Acute Ischemic Stroke Management
German Centre for Cardiovascular Research
2017-2025
Charité - Universitätsmedizin Berlin
1999-2025
Deutsches Herzzentrum der Charité
2016-2025
Humboldt-Universität zu Berlin
1995-2025
Freie Universität Berlin
2023-2025
Berlin Heart (Germany)
2011-2024
Deutsches Herzzentrum München
2022
Auguste-Viktoria-Klinik
2022
ETH Zurich
2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2018
We sought to evaluate the outcomes of transcatheter mitral valve replacement (TMVR) for patients with degenerated bioprostheses [valve-in-valve (ViV)], failed annuloplasty rings [valve-in-ring (ViR)], and severe annular calcification [valve-in-mitral (ViMAC)].From TMVR multicentre registry, procedural clinical ViV, ViR, ViMAC were compared according Mitral Valve Academic Research Consortium (MVARC) criteria. A total 521 mean Society Thoracic Surgeons score 9.0 ± 7.0% underwent (322 141 58...
Transcatheter aortic valve implantation (TAVI) has matured into a standard treatment option for patients with severe symptomatic stenosis (AS) across the whole spectrum of risk. The advances in interventional AS raise question which should be referred to surgery. myriad clinical permutations does not allow providing single, uniform strategy. Rather, advent TAVI along established surgical replacement (SAVR) fundamentally enforces role multidisciplinary heart team decision-making recommending...
Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There no data on long-term outcomes after ViV. Our aim was perform a large-scale assessment of survival and reintervention ViV.A total 1006 ViV performed more than 5 years ago [mean age 77.7 ± 9.7 years; 58.8% male; median STS-PROM score 7.3% (4.2-12.0)] were included in the analysis. Patients treated with Medtronic self-expandable valves (CoreValve/Evolut, Inc., Minneapolis, MN, USA)...
Peri-procedural transcatheter valve embolization and migration (TVEM) is a rare but potentially devastating complication of aortic implantation (TAVI). We sought to assess the incidence, causes, outcome TVEM in large multicentre cohort.We recorded cases peri-procedural patients undergoing TAVI between January 2010 December 2017 from 26 international sites. occurred 273/29 636 (0.92%) (age 80.8 ± 7.3 years; 53.8% female), which 217 were ascending aorta 56 left ventricle. The use...
Mitral valve-in-valve (ViV) and valve-in-ring (ViR) are alternatives to surgical reoperation in patients with recurrent mitral valve failure after previous repair or replacement. Our aim was perform a large-scale analysis examining midterm outcomes ViV ViR.Patients undergoing ViR were enrolled the Valve-in-Valve International Data Registry. Cases performed between March 2006 2020. Clinical endpoints reported according Valve Academic Research Consortium (MVARC) definitions. Significant...
Background— Transcatheter caval valve implantation is under evaluation as a treatment option for inoperable patients with severe tricuspid regurgitation (TR). The procedure involves the catheter-based of bioprosthetic valves in inferior vena cava and superior to treat symptoms associated TR. This study first evaluate feasibility, safety, efficacy this interventional concept. Methods Results— Twenty-five (mean age, 73.9±7.6 years; women, 52.0%) symptomatic TR despite optimal medical deemed...
Abstract Background and Aims This trial sought to assess the safety efficacy of ShortCut, first dedicated leaflet modification device, prior transcatheter aortic valve implantation (TAVI) in patients at risk for coronary artery obstruction. Methods pivotal prospective study enrolled with failed bioprosthetic valves scheduled undergo TAVI were The primary endpoint was procedure-related mortality or stroke discharge 7 days, per-patient splitting success. Independent angiographic,...
Since the first description of a characteristic clinical neuropsychiatric picture in patient with Hashimoto thyroiditis by Brain et al.1 1966, several patients similar or identical symptoms have been reported and Hashimoto’s encephalopathy (HE) has generally accepted as separate type encephalopathy.2 Major characteristics include generalized focal seizures, stroke-like events, temporary neurologic deficits, variety psychiatric disturbances from dementia to visual hallucinations frank...
Negative pressure wound therapy (NPWT) is a recently introduced treatment modality for post-sternotomy mediastinitis. The aim of this study was to compare the mortality rate, sternal re-infection rate and length hospital stay in patients with mediastinitis after NPWT conventional treatment.We retrospectively analysed 118 cardiac surgery. One group 69 treated other 49 therapy.There were no major differences between two groups concerning preoperative data (EuroScore) or primary surgery (mainly...
Objective: Transapical aortic valve implantation (TAVI) is a new method that might reduce the surgical risk of conventional replacement in very high-risk patients. Increased downstream microembolization expected transapical implantation. However, whether it usually occurs, how often, and its clinical relevance are not known. We report results ultrasound microembolic signal detection middle cerebral artery during procedure. Methods: Fifty patients (mean age: 80 ± 5 years; mean EuroSCORE: 36...
Iatrogenic damage of different structures the aortic root, in region so-called "device landing zone," may occur during transcatheter valve implantation (TAVI). It is mostly considered difficult to treat or even untreatable.We performed a retrospective analysis occurrence, clinical presentation, treatment, and outcome iatrogenic rupture device zone series 618 consecutive patients who underwent TAVI at our institution between April 2008 October 2011. The incidence was 1% (6 patients). correct...
Minimally invasive surgical mitral valve repair (MVRepair) has become routine for the treatment of regurgitation, and indications have been expanded to include reoperations. Current European Society Cardiology/European Association Cardio-Thoracic Surgery guidelines management valvular heart disease recommended standards in terms differentiation, timing intervention techniques improve patient care. Numerous minimally lessen invasiveness described, such as minimal-access J-sternotomy...
Background: Patients with severe tricuspid regurgitation present late and are often ineligible for surgery or transcatheter repair systems. Transfemoral venous implantation of a bicaval valved stent has been proposed as therapeutic option in selected patients. The aim this study was to summarize the early procedural clinical outcomes novel TRICENTO system treatment patients symptomatic regurgitation. Methods: All consecutive treated custom-made implant at participating centers were included...