A5055010337- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- Lipoproteins and Cardiovascular Health
- Coronary Interventions and Diagnostics
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Drug Transport and Resistance Mechanisms
- Acute Myocardial Infarction Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cell Adhesion Molecules Research
- Genetics and Neurodevelopmental Disorders
- Cardiac Valve Diseases and Treatments
- Neurological disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Medical Research and Treatments
- Cardiac pacing and defibrillation studies
- Healthcare and Venom Research
Guangzhou University of Chinese Medicine
2023-2025
Kunming Medical University
2008-2025
Houston Methodist
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2013-2024
Shanghai University of Traditional Chinese Medicine
2013-2024
Sichuan University
2024
West China Second University Hospital of Sichuan University
2024
Shanxi Medical University
2024
Shanxi Academy of Medical Sciences
2024
Shandong University of Traditional Chinese Medicine
2024
Abstract Chromatin remodeling has emerged as a hallmark of gastric cancer, but the regulation chromatin regulators other than genetic change is unknown. Helicobacter pylori causes epigenetic dysregulation to promote carcinogenesis, roles and functions microRNAs (miRNA) in this multistage cascade are not fully explored. In study, miRNA expression preneoplastic neoplastic lesions murine stomachs induced by H. N-methyl-N-nitrosourea (MNU) was profiled array. miR-490-3p exhibited progressive...
Hepatocellular carcinoma (HCC) is one of the most lethal malignant diseases worldwide. Despite advances in diagnosis and treatment HCC, its overall prognosis remains poor. Recent studies have shown that long noncoding RNAs (lncRNAs) play crucial roles various pathophysiological processes, including liver cancer. In current study, we report lncRNA SLC2A1-AS1 frequently downregulated HCC samples, as by quantitative real-time polymerase chain reaction analysis. deletion significantly associated...
Abstract Long non‐coding RNA (lncRNA) is an important regulatory factor in the development of lung adenocarcinoma, which related to control autophagy. LncRNA can also be used as a biomarker prognosis patients with adenocarcinoma. Therefore, it determine prognostic value autophagy‐related lncRNA In this study, mRNAs‐lncRNAs were screened from adenocarcinoma and co‐expression network was constructed by using The Cancer Genome Atlas (TCGA). univariate multivariate Cox proportional hazard...
PFIC II is a subtype of progressive familial intrahepatic cholestasis (PFIC) that associated with mutations in the ABCB11 gene encoding bile salt export pump (BSEP). However it not known how these cause this disease. To evaluate mechanisms, we introduced seven II–associated missense into rat Bsep and assessed their effects on membrane localization transport function MDCK Sf9 cells, respectively. Five mutations, G238V, E297G, G982R, R1153C, R1268Q, prevented protein from trafficking to apical...
To investigate the therapeutic effect of different doses low energy shock wave therapy (LESWT) on erectile dysfunction (ED) in streptozotocin (STZ) induced diabetic rats. SD rats (n = 75) were randomly divided into 5 groups (normal control, 3 dose LESWT treated groups). Diabetic by intra-peritoneal injection STZ (60 mg/kg) and with fasting blood glucose ≥ 300 mg/dL selected as models. Twelve weeks later, (100, 200 shocks each time) treatment penises used to treat ED (7.33 MPa, 2 shocks/s)...
Discoidin Domain Receptor 1 (DDR1) belongs to the family of collagen receptor tyrosine kinases that confers progression various cancers. Aberrant expression DDR1 was detected in several human cancers including ovarian cancer, which had been shown increase migration and invasion tumor cells. However, precise mechanisms underlying abnormal cancer has not well investigated previous studies.In this work, a negative correlation between suppressor miRNA, miR-199a-3p, observed tissues. Furthermore,...
Abstract In recent years, circular RNA s (circ s) have been revealed to important roles in carcinogenesis. Metastasis is the leading cause of lung adenocarcinoma ( LUAC ) death. However, contributions circ metastasis remain largely unknown. Based on circBase data and our biobank tissues, we identified CRIM 1 (a derived from exons 2, 3 4 gene, hsa_circ_0002346) as having a significantly decreased expression samples compared with matched normal control samples. Both vivo vitro experiments that...
PFIC II is a subtype of progressive familial intrahepatic cholestasis (PFIC) that associated with mutations in the ABCB11 gene encoding bile salt export pump (BSEP). However it not known how these cause this disease. To evaluate mechanisms, we introduced seven II–associated missense into rat Bsep and assessed their effects on membrane localization transport function MDCK Sf9 cells, respectively. Five mutations, G238V, E297G, G982R, R1153C, R1268Q, prevented protein from trafficking to apical...
The bile salt export pump (Bsep) represents the major transport system at canalicular membrane of hepatocytes. When examined in model cell lines, genetic mutations BSEP gene impair its targeting and function, contributing to pathogenesis progressive familial intrahepatic cholestasis type II (PFIC II). PFIC are known lead a deficiency human hepatocytes, suggesting that mutants unstable degraded cell. To investigate this further, we have characterized impact several on processing stability rat...
Dysregulation of long non-coding RNAs (LncRNAs) participated into the initiation and progression different diseases via direct regulation proteins or indirect microRNA (miRNA)-target genes. LINC00473 is a novel carcinoma-related LncRNA up-regulated in many cancers for tumor growth metastasis, but its role chemotherapy resistance unclear. We here investigated function colorectal cancer (CRC) vitro vivo The CRC tissues (n=20) relative normal were collected found that was overexpressed when...
The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), and red cell distribution width (RDW) are markers of systemic inflammation with prognostic significance for cancers. aim the study was to investigate predictive pretreatment values NLR, PLR, RDW in cervical cancer. We retrospectively analyzed 515 patients Median NLR PLR were higher cancer compared controls consistently elevated during tumor progression, while uninformative. Increased associated lymph node (LN) metastasis depth...
Abstract There is accumulating evidence that histidine triad (HIT) nucleotide-binding protein 1 (HINT1), a member of the evolutionary highly conserved HIT super family, novel tumor suppressor. However, mechanism action HINT1 with respect to suppression not known. In present study, we found series human colon cancer cell lines displayed various levels expression HINT1, very low level in SW480 cells. This line also partial methylation promoter region Hint1 gene, and treatment these cells...
The graded mechanical properties (e.g., stiffness and stress/strain) of excellular matrix play an important role in guiding cellular alignment, as vital tissue reconstruction with proper functions. Though various methods have been developed to engineer a environment study its effect on behaviors, most them failed distinguish from stress/strain during loading. Here, we construct programmable strain gradients by using hydrogel linear elastic property. When seeding cells such hydrogels,...
Abstract Breast cancer is the most frequently diagnosed and leading cause of death among women worldwide. Long non-coding RNAs (lncRNAs) are a class in human genome that involves breast development progression. Here, we identify lncRNA, LINC00978, which upregulated cell lines tissues compared with corresponding controls. Furthermore, LINC00978 expression negatively associated hormone receptor (HR) status 195 patients studied ( p = 0.033). Kaplan–Meier survival analysis shows high have poorer...
Association between palliative case management (PCM) and the utilization of major health services during last 30 days life in Medicaid patients with cancer was assessed using retrospective cohort analysis. There were 132 PCM enrollees intervention group 54 non-PCM comparison group. The had lower inpatient admission rate than that (56.8% vs 74.1%), ICU (12.9% 24.1%), longer mean hospice (45.8 31.1 days), percentage persons death hospital (24.2% 35.9%). No statistically significant differences...
Invadopodium formation is a crucial early event of invasion and metastasis hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying regulation invadopodia remain elusive. This study aimed to investigate potential role discs large homolog 5 (Dlg5) in invadopodium function HCC. We found that Dlg5 expression was significantly lower human HCC tissues cell lines than adjacent nontumor liver cells. Lower associated with advanced stages HCC, poor overall disease‐free survival...
Living cells can alter their shapes and functions in response to physical cues at the cell–substrate interface, consequently temporal variations of substrate surface are thought be very important governing cell behaviors. In this study, a thermally-activated shape memory function was employed tune dynamic change topography features on polymer nanocomposite substrate. The is composed chemically cross-linked poly(ε-caprolactone) with allyl alcohol Fe3O4 nanoparticles. regular arrays...
Questions exist regarding the causal relationship between malnutrition and stroke outcomes. This study aimed to determine whether nutritional status changes or during hospitalisation could predict 3-month outcomes in acute patients.During a 10-month period, patients who suffered their first within 7 days after onset were included this prospective multi-centre study. The demographic parameters, risk severity factors, factors dysphagia recorded. Nutritional was assessed by 3 anthropometric...
Microchannels often serve as highways for cancer migration, and their topology largely determines the migration efficiency. Curvature, a topological parameter in biological systems, has recently been reported to be efficient guiding cell polarization migration. Curvature varies widely along curved microchannels, while its influence on remains elusive. Here, we recapitulated observed clinical tumor tissues with hydrogels, studied how cells respond curvature. We found that bend more...
Background: This study evaluates the effects of hydroxytyrosol (HT), a component olive oil, on mammographic breast density reduction. We explored HT Wnt β-catenin and other pathways involved in cancer stem cell renewal, DNA repair, proliferation, differentiation. Methods: Twenty-five milligrams per day oral dose was given for 12 months pre- postmenopausal women at increased risk cancer. Out 51 patients enrolled, 41 completed study. The annualized percent decrease maximum volumetric (max...