A5100718618- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- COVID-19 Pandemic Impacts
- Psoriasis: Treatment and Pathogenesis
- Chromatin Remodeling and Cancer
- SARS-CoV-2 detection and testing
- High voltage insulation and dielectric phenomena
- Mechanisms of cancer metastasis
- Respiratory viral infections research
- Genomics and Chromatin Dynamics
- Data-Driven Disease Surveillance
- Protein Degradation and Inhibitors
- COVID-19 Clinical Research Studies
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- COVID-19 impact on air quality
- vaccines and immunoinformatics approaches
- Genomics and Rare Diseases
- Thermal Analysis in Power Transmission
- Animal Disease Management and Epidemiology
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
Hong Kong Jockey Club
2015-2025
Chinese University of Hong Kong
2016-2025
University of York
2025
Cornell University
2025
Southwest Medical University
2025
City University of Hong Kong, Shenzhen Research Institute
2015-2024
University of Hong Kong
2015-2024
Henan Cancer Hospital
2024
Zhengzhou University
2023-2024
Chinese University of Hong Kong, Shenzhen
2015-2024
In December 2019, an outbreak of respiratory illness caused by a novel coronavirus (2019-nCoV) emerged in Wuhan, China and has swiftly spread to other parts number foreign countries. The 2019-nCoV cases might have been under-reported roughly from 1 15 January 2020, thus we estimated the unreported basic reproduction number, R0, 2019-nCoV.We modelled epidemic curve cases, mainland 2019 24 2020 through exponential growth. was determined maximum likelihood estimation. We used serial intervals...
There is a need for effective and safe treatment during pregnancy in women with chronic inflammatory diseases. This study evaluated placental transfer of certolizumab pegol (CZP), an Fc-free anti-tumour necrosis factor drug, from CZP-treated pregnant to their infants.
Increased renewable energy integration and international power trades have led to the construction development of new HVDC transmission systems. cables, in particular, play an important role undersea offshore having lower losses higher reliability. In this paper, current commercial feasibility cables different types accessories are reviewed. The non-uniform electric field distribution caused by applied voltage, temperature dependent conductivity, space charge accumulation is briefly...
Asymptomatic transmission of the coronavirus disease 2019 is an important topic. A recent study in China showed that transmissibility asymptomatic cases comparable to symptomatic cases. Here, we discuss conclusion may depend on how interpret data. To best our knowledge, this first time relative COVID-19 infections quantified.
Abstract Backgrounds An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit major city China, Wuhan, December 2019 and subsequently reached other provinces/regions China countries. We present estimates the basic reproduction number, R 0 , 2019-nCoV in early phase outbreak. Methods Accounting for impact variations disease reporting rate, we modelled epidemic curve cases time series, mainland from January 10 to 24, 2020, through exponential growth. With estimated intrinsic growth...
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant viral pathogenicity. Here, by transcriptome analysis, we demonstrated inflammasome-related NOD-like receptor signaling was activated in SARS-CoV-2-infected lung epithelial cells and Disease 2019 (COVID-19) patients' tissues. The induction inflammasomes/pyroptosis patients with severe COVID-19 confirmed serological markers....
ABSTRACT Background The combined effects of some modifiable lifestyle factors on incident inflammatory bowel disease (IBD) are uncertain. Aims To evaluate the association between healthy behaviours and IBD incidence. Methods This population‐based prospective cohort study used data from UK Biobank. We included 105,715 participants aged 40–70 who had no diagnosis at baseline in analyses. five that we studied were never smoking, optimal sleep, high level vigorous physical activity, dietary...
Summary Background The outbreak of coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization, while several key epidemiological parameters remain to be clarified. This study aimed obtain robust estimates incubation period, upper limit latent period (interval between infector’s exposure and infectee’s exposure), serial interval, time point (the day infector relative latter’s symptom onset date) basic reproduction number (R 0 ) COVID-19. Methods Between...
Abstract Chromatin remodeling has emerged as a hallmark of gastric cancer, but the regulation chromatin regulators other than genetic change is unknown. Helicobacter pylori causes epigenetic dysregulation to promote carcinogenesis, roles and functions microRNAs (miRNA) in this multistage cascade are not fully explored. In study, miRNA expression preneoplastic neoplastic lesions murine stomachs induced by H. N-methyl-N-nitrosourea (MNU) was profiled array. miR-490-3p exhibited progressive...
Abstract Background Altered microbiome composition and aberrant promoter hypermethylation of tumor suppressor genes (TSGs) are two important hallmarks colorectal cancer (CRC). Here we performed concurrent 16S rRNA gene sequencing methyl-CpG binding domain-based capture in 33 tissue biopsies (5 normal colonic mucosa tissues, 4 pairs adenoma adenoma-adjacent 10 CRC CRC-adjacent tissues) to identify significant associations between TSG CRC-associated bacteria, followed by functional validation...
Since the first case of coronavirus disease 2019 (COVID-19) in Africa was detected on February 14, 2020, cumulative confirmations reached 15 207 including 831 deaths by April 13, 2020. has been described as one most vulnerable region with COVID-19 infection during initial phase outbreak, due to fact that is a great commercial partner China and some other EU American countries. Which result large volume travels traders more frequently causing African countries face even bigger health threat...
The coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China on December patients presenting with atypical pneumonia. Although 'city-lockdown' policy reduced the spatial spreading of COVID-19, city-level outbreaks within each city remain a major concern to be addressed. local or regional level control mainly depends individuals self-administered infection prevention actions. contradiction between choice taking actions not makes elimination difficult under voluntary acting...
The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which becomes prevalent the UK rapidly, is one of major challenges COVID-19 control. To explore transmission advantage, we estimate that substitution increases infectivity by 52% (95% confidence interval: 46, 58) terms reproduction number.
With modern power utilities going green by utilising renewable energy technologies and the development of smart grid, high-voltage direct current (HVDC) become more important in transmission. In particular, HVDC cable systems play a prominent role undersea transmission offshore integration. As an essential part complete system, termination is one most critical components. The mathematical physical background discussed various types terminations reviewed. Regarding non-uniform field...