A5084377118- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Cancer Risks and Factors
- DNA Repair Mechanisms
- RNA modifications and cancer
- Toxic Organic Pollutants Impact
- Nutrition, Genetics, and Disease
- BRCA gene mutations in cancer
- Air Quality and Health Impacts
- DNA and Nucleic Acid Chemistry
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Mycotoxins in Agriculture and Food
- Cancer-related gene regulation
- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Genetic factors in colorectal cancer
- Gene expression and cancer classification
- Folate and B Vitamins Research
Columbia University
2015-2024
Columbia University Irving Medical Center
2014-2024
Icahn School of Medicine at Mount Sinai
2007-2021
San Diego State University
2021
The University of Texas MD Anderson Cancer Center
2010-2020
Arkansas Department of Agriculture
2020
John Wiley & Sons (United States)
2020
Hudson Institute
2020
University of North Carolina at Chapel Hill
2007-2017
University of South Carolina
2016-2017
<h3>Context</h3>Secondary analyses of 2 randomized controlled trials and supportive epidemiologic preclinical data indicated the potential selenium vitamin E for preventing prostate cancer.<h3>Objective</h3>To determine whether selenium, E, or both could prevent cancer other diseases with little no toxicity in relatively healthy men.<h3>Design, Setting, Participants</h3>A randomized, placebo-controlled trial (Selenium Vitamin Cancer Prevention Trial [SELECT]) 35 533 men from 427...
Reduced levels of global DNA methylation are associated with genomic instability and independent predictors cancer risk. Little is known about the environmental determinants in peripheral blood. We examined association between demographic lifestyle factors leukocyte 161 cancer-free subjects enrolled North Texas Healthy Heart Study aged 45–75 years 2008. used in-person interviews for demographics factors, a self-administrated Block food frequency questionnaire diet, bioelectrical impedance...
We have examined DNA from four human esophageal carcinoma cell lines and 50 primary carcinomas obtained China, Italy, France for amplification of the cyclin D1 gene. also 36 these expression retinoblastoma (RB) proteins by immunohistochemistry. found a 3- to 10-fold gene in 16 (32%) tumors two lines. Cyclin protein was overexpressed 12 13 that showed when compared normal controls. Studies on RB indicated 6 (17%) tumor samples one line did not show detectable this protein. The had...
Prostate cancer continues to be a major health threat, especially among African American men. The Selenium and Vitamin E Cancer Prevention Trial (SELECT), which opened on July 25, 2001, was planned study possible agents for the prevention of prostate in population 32,400 men United States, including Puerto Rico, Canada. SELECT is phase III randomized, placebo-controlled trial selenium (200 microg/day from L-selenomethionine) and/or vitamin (400 IU/day all rac alpha-tocopheryl acetate)...
Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased postmenopausal women. It unclear whether this association mediated through shared genetic or environmental factors.
The etiology of familial breast cancer is complex and involves genetic environmental factors such as hormonal lifestyle factors. Understanding aggregation a key to understanding the causes facilitating development effective prevention therapy. To address urgent research questions expedite translation results clinical setting, National Cancer Institute (USA) supported in 1995 establishment novel infrastructure, Breast Family Registry, collaboration six academic institutions their medical...
The authors briefly review the current potential and limitations of molecular epidemiology. This approach uses biomarkers to measure internal bioeffective dose toxicants, early biologic effects likely be predictive cancer, variations in individual susceptibility. most frequent application has been assessment exposure/dose susceptibility due genetic nongenetic factors. More research is needed establish significance terms disease risk. To illustrate that epidemiology identifying etiologic...
The presence of covalent DNA chemical addition products (adducts) in human term placentas was investigated by recently developed immunologic and 32P-postlabeling assays. from placental specimens smokers showed a small but not statistically significant increase adduct levels when tested antibodies to modified with benzo[ ]pyrene dihydrodiol epoxide (BPDE-I), the ultimate carcinogenic derivative ]pyrene. postlabeling assay detected several nucleotides, one which (adduct 1) strongly related...
To investigate the carcinogenic effect of environmental aflatoxin exposure, 56 cases hepatocellular carcinoma (HCC) diagnosed between 1991 and 1995 were identified individually matched by age, sex, residence date recruitment to 220 healthy controls from same large cohort in Taiwan. Blood samples analyzed for hepatitis B C viral markers aflatoxin-albumin adducts; urine was tested metabolites. We obtained information about socio-demographic characteristics, habitual alcohol drinking, cigarette...
Abstract Purpose: Most hepatocellular carcinomas (HCC) are diagnosed at an advanced stage. Hypermethylation of CpG islands in promoter regions is now recognized as important early event carcinogenesis and detection methylated DNA has been suggested a potential biomarker for cancer. There no studies on epigenetic changes samples from HCC patients before diagnosis. We explored the possible diagnostic value aberrant hypermethylation three tumor suppressor genes serum HCC. Experimental Design:...
Alterations in DNA methylation frequently occur hepatocellular cancer (HCC). We have previously demonstrated that hypermethylation candidate genes can be detected plasma before HCC diagnosis. To identify, with a genome-wide approach, additional hypermethylated could used for more accurate analysis of early diagnosis, we analyzed tumor and adjacent nontumor tissues from 62 Taiwanese cases using Illumina arrays (Illumina, Inc., San Diego, CA) screen 26,486 autosomal CpG sites. After Bonferroni...
Changes in DNA methylation may represent an intermediate step between the environment and human diseases. Little is known on whether behavioral risk factors modify gene expression through methylation. To assess associated with different levels of physical activity, we measured global genomic using bisulfite converted real time PCR (MethyLight) for LINE-1 peripheral blood 161 participants aged 45-75 years enrolled North Texas Healthy Heart Study activity accelerometer (Actigraph GT1M...
Abstract BACKGROUND It is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa). METHODS We examined hypothesis plasma miRNA levels can differentiate patients by aggressiveness in 82 PCa patients. Taqman based quantitative RT‐PCR assays were performed to measure copy number target miRNAs. RESULTS miR‐20a was significantly overexpressed from stage 3 tumors compared 2 or below ( P = 0.03). The expression for miR‐21...
Abstract One plausible mechanism for the environment to alter cancer susceptibility is through DNA methylation. Alterations in methylation can lead genomic instability and altered gene transcription. Genomic levels have been inversely associated with age, suggesting that factors throughout life may be declines Using information from a multiethnic New York City birth cohort (born between 1959 1963), we examined whether methylation, measured peripheral blood mononuclear cells, was smoking...
Accumulating evidence from epidemiologic studies suggests that risk of breast cancer is reduced in relation to increased consumption folate and related B vitamins. We investigated independent joint effects vitamin intake as well two polymorphisms a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T 1298A>C] on risk. The study uses the resources population-based case-control study, which includes 1,481 cases 1,518 controls. Significant inverse...