A5011642832- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Urologic and reproductive health conditions
- Renal and related cancers
- Urinary Bladder and Prostate Research
- Ureteral procedures and complications
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Molecular Biology Techniques and Applications
- Renal and Vascular Pathologies
- Hormonal and reproductive studies
- Cancer Genomics and Diagnostics
- MRI in cancer diagnosis
- Colorectal Cancer Screening and Detection
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Organ Donation and Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Amino Acid Enzymes and Metabolism
Columbia University
2010-2023
Columbia University Irving Medical Center
2011-2021
New York Hospital Queens
2004-2020
NewYork–Presbyterian Hospital
2009-2020
Sidney Kimmel Cancer Center
2017
University of Pennsylvania
2017
New York Proton Center
2005-2016
Columbia College
1999-2016
Royal College of Physicians
1999-2016
Memorial Sloan Kettering Cancer Center
2013
Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent prostate cancer. We compared docetaxel plus estramustine mitoxantrone prednisone metastatic, hormone-independent cancer.We randomly assigned 770 to one of two treatments, each given 21-day cycles: 280 mg three times daily on days 1 through 5, 60 per square meter body-surface area day 2, and dexamethasone divided doses before docetaxel, or 12 5 twice daily. The primary end...
Isolated prostate specific antigen (PSA) determinations in asymptomatic individuals have not demonstrated sufficient sensitivity and specificity to be useful the routine evaluation of disease. To enhance accuracy serum PSA we used a quotient volume, which refer as density (PSAD). Prostate volume this study was calculated from magnetic resonance imaging benign prostatic hypertrophy (BPH) or dimensions surgical specimen cancer using formula, length x width depth 0.5 = volume. A total 61...
Prostate specific antigen (PSA) is an extremely valuable tumor marker. However, its use in detection limited by low positive and negative predictive values. The ability of serum PSA to distinguish between benign malignant prostatic conditions particularly poor the intermediate range 4.1 10 ng./ml. Hybritech assay. We used transrectal ultrasound determined prostate volumes a well characterized population 533 men form PSA/prostate volume ratio called density (PSAD). prevalence cancer entire...
PURPOSE: To evaluate the toxicity, efficacy, and pharmacokinetics of docetaxel when combined with oral estramustine dexamethasone in a phase I study patients progressive metastatic androgen-independent prostate cancer. PATIENTS AND METHODS: Thirty-four men were stratified into minimally pretreated (MPT) extensively (EPT) groups. Estramustine 280 mg PO tid was administered 1 hour before or 2 hours after meals on days through 5, escalated doses from 40 to 80 mg/m day 2. Treatment repeated...
Background: The identification of surrogate endpoints that can replace true outcome is crucial to the rapid evaluation new cancer drugs. Retrospective analyses phase II and III trials in metastatic androgen-independent prostate have shown associations between declines serum prostate-specific antigen (PSA) levels survival. We evaluated PSA changes as potential markers for survival by using data from a clinical trial. Methods: Men with were randomly assigned either docetaxel/estramustine (D/E)...
Glucocorticoids induce tyrosine aminotransferase (EC 2.6.1.5) synthesis in cultured rat hepatoma cells. These steroids penetrate the cell membrane and bind to specific cytoplasmic receptor proteins. The resulting complex binds nucleus. This nuclear binding has now been studied a cell-free preparation. reaction appears require temperature-dependent modification of steroid-receptor complex. There is fixed number sites that are half saturated at concentration 6 24 × 10 -11 M. Treatment with...
Abstract We examined a series of 29 surgical specimens benign and malignant human prostate tissue for the expression both cHa ‐ ras c myc protooncogenes. Northern blots were prepared using polyadenylated mRNA extracted from nine prostatic adenocarcinomas, 19 hypertrophied prostates (BPH) one normal prostate. When hybridized to probe , only specimen BPH showed an appreciable amount 1.2‐kb transcript homologous . Upon reprobing these with six cancers considerable 2.4‐kb Three other all little...
Abstract BACKGROUND It is becoming increasingly evident that microRNAs (miRNAs) are associated with the development and progression of prostate cancer (PCa). METHODS We examined hypothesis plasma miRNA levels can differentiate patients by aggressiveness in 82 PCa patients. Taqman based quantitative RT‐PCR assays were performed to measure copy number target miRNAs. RESULTS miR‐20a was significantly overexpressed from stage 3 tumors compared 2 or below ( P = 0.03). The expression for miR‐21...
Prior phase II studies of intravesical gemcitabine have shown it to be active and well tolerated, but durable responses in patients with nonmuscle invasive bladder cancer who experienced recurrence after bacillus Calmette-Guérin treatment are uncommon. We performed a multi-institutional study within the SWOG (Southwest Oncology Group) cooperative group evaluate potential role induction plus maintenance therapy this setting.
A three-gene panel derived from mechanistic models of cell senescence predicts outcome low Gleason score prostate tumors.
No AccessJournal of UrologyAdult Urology1 Mar 2013Long-Term Survival Outcomes with Intravesical Docetaxel for Recurrent Nonmuscle Invasive Bladder Cancer After Previous Bacillus Calmette-Guérin Therapy LaMont J. Barlow, James M. McKiernan, and Mitchell C. Benson BarlowLaMont Barlow , McKiernanJames McKiernan BensonMitchell View All Author Informationhttps://doi.org/10.1016/j.juro.2012.10.068AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints...
Objectives. Cellular senescence is a unique cellular response pathway thought to be closely associated with the aging process. The senescent phenotype characterized by loss of cell's ability respond proliferative and apoptotic stimuli even while normal metabolic activity vitality maintained. Recently, novel biomarker, senescent-associated beta-galactosidase (SA-β-gal), was found identify cells phenotype. In present study, we examined whether human prostatic epithelial adopt...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Oct 2001SALVAGE CRYOTHERAPY USING AN ARGON BASED SYSTEM FOR LOCALLY RECURRENT PROSTATE CANCER AFTER RADIATION THERAPY: THE COLUMBIA EXPERIENCE MOHAMED A. GHAFAR, CHRISTOPHER W. JOHNSON, ALEXANDER DE LA TAILLE, MITCHELL C. BENSON, EMILIA BAGIELLA, MARIE FATAL, CARL OLSSON, and AARON E. KATZ GHAFARMOHAMED GHAFAR , JOHNSONCHRISTOPHER JOHNSON TAILLEALEXANDER TAILLE BENSONMITCHELL BENSON BAGIELLAEMILIA BAGIELLA FATALMARIE FATAL...
Abstract Androgen deprivation subsequent to castration of an adult male rat results in the regression sexual accessory tissues. Regression these tissues involves massive death androgen‐dependent cells. Using ventral prostate gland as a model study androgen‐programed cell death, we have characterized series molecular events that accompany its regression. This analysis has shown there was sequential induction specific gene transcripts following castration. The first event this cascade abrupt...