A5081580894- Cardiac Valve Diseases and Treatments
- Heart Rate Variability and Autonomic Control
- Prostate Cancer Treatment and Research
- Epilepsy research and treatment
- Cardiac Structural Anomalies and Repair
- Prostate Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Pharmacological Effects and Toxicity Studies
- Cardiac Health and Mental Health
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Blood Pressure and Hypertension Studies
- Mechanical Circulatory Support Devices
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Heart Failure Treatment and Management
- Acute Ischemic Stroke Management
- Neonatal and fetal brain pathology
- Religion, Spirituality, and Psychology
Icahn School of Medicine at Mount Sinai
2016-2025
Athinoula A. Martinos Center for Biomedical Imaging
2024
Harvard University
2024
Spaulding Rehabilitation Hospital
2024
Massachusetts General Hospital
2020-2024
Mount Sinai Health System
2024
Mount Sinai Hospital
2012-2024
Institute of Population and Public Health
2022
Center for Discovery
2021
Boston University
2021
In a randomized trial comparing mitral-valve repair with replacement in patients severe ischemic mitral regurgitation, we found no significant difference the left ventricular end-systolic volume index (LVESVI), survival, or adverse events at 1 year after surgery. However, group had significantly more recurrences of moderate regurgitation. We now report 2-year outcomes this trial.We randomly assigned 251 to replacement. Patients were followed for 2 years, and clinical echocardiographic...
Ischemic mitral regurgitation is associated with a substantial risk of death. Practice guidelines recommend surgery for patients severe form this condition but acknowledge that the supporting evidence repair or replacement limited.
Cognitive function was examined in 227 patients three months after admission to hospital for ischaemic stroke, and 240 stroke-free controls, using 17 scored items that assessed memory, orientation, verbal skills, visuospatial ability, abstract reasoning, attentional skills. After adjusting demographic factors with standardised residual scores all subjects, the fifth percentile used controls as criterion failure on each item. The mean (SD) number of failed 3.4 (3.6) stroke 0.8 (1.3) (p <...
Amantadine hydrochloride is one of the most commonly prescribed medications for patients with prolonged disorders consciousness after traumatic brain injury. Preliminary studies have suggested that amantadine may promote functional recovery.We enrolled 184 who were in a vegetative or minimally conscious state 4 to 16 weeks injury and receiving inpatient rehabilitation. Patients randomly assigned receive placebo followed 2 treatment was discontinued. The rate recovery on Disability Rating...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new human with few effective treatments1. Convalescent plasma, donated persons who have recovered from COVID-19, the acellular component of blood that contains antibodies, including those specifically recognize SARS-CoV-2. These when transfused into patients infected SARS-CoV-2, are thought to exert an antiviral effect, suppressing virus replication before mounted their own...
In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients moderate ischemic mitral regurgitation, we found no significant difference the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant was associated reduced prevalence of severe but had more adverse events. We now report 2-year outcomes.We randomly assigned 301 to undergo either combined procedure. Patients were followed for 2 years clinical and...
Among patients undergoing mitral-valve surgery, 30 to 50% present with atrial fibrillation, which is associated reduced survival and increased risk of stroke. Surgical ablation fibrillation has been widely adopted, but evidence regarding its safety effectiveness limited.We randomly assigned 260 persistent or long-standing who required surgery undergo either surgical (ablation group) no (control during the operation. Patients in group underwent further randomization pulmonary-vein isolation a...
Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients moderate regurgitation, the benefits of adding mitral-valve repair to coronary-artery bypass grafting (CABG) are uncertain.
Atrial fibrillation after cardiac surgery is associated with increased rates of death, complications, and hospitalizations. In patients postoperative atrial who are in stable condition, the best initial treatment strategy--heart-rate control or rhythm control--remains controversial.Patients new-onset were randomly assigned to undergo either rate control. The primary end point was total number days hospitalization within 60 randomization, as assessed by Wilcoxon rank-sum test.Postoperative...
Background— Right ventricular (RV) morphology is an important predictor of outcomes in heart and lung disease; however, determinants RV anatomy have not been well studied. We examined the demographic factors associated with function a population-based multiethnic sample free clinical cardiovascular disease. Methods Results— In Multi-Ethnic Study Atherosclerosis (MESA), cardiac magnetic resonance imaging was performed on 5098 participants. volumes mass were available for 4204 Normative...
Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE acute injury that evolves HS.FEBSTAT 2 affiliated studies prospectively recruited 226 children aged 1 month 6 years with controls simple seizures. All had magnetic resonance imaging (MRI), follow-up MRI was obtained approximately year later in the majority. Visual interpretation by neuroradiologists informed only of...
Idiopathic pulmonary fibrosis is often initially misdiagnosed. Delays in accessing subspecialty care could lead to worse outcomes among those with idiopathic fibrosis.
Diabetes and hyperinsulinemia may be risk factors for Alzheimer's disease (AD). We conducted a pilot study of metformin, medication efficacious in treating preventing diabetes while reducing hyperinsulinemia, among persons with amnestic mild cognitive impairment (aMCI) the goal collec ting preliminary data on feasibility, safety, efficacy. Participants were 80 men women aged 55 to 90 years aMCI, overweight or obese, without treated diabetes. randomized participants metformin 1000 mg twice...
Background COVID-19 has infected millions of people worldwide and is responsible for several hundred thousand fatalities. The pandemic necessitated thoughtful resource allocation early identification high-risk patients. However, effective methods to meet these needs are lacking. Objective aims this study were analyze the electronic health records (EHRs) patients who tested positive admitted hospitals in Mount Sinai Health System New York City; develop machine learning models making...
Tricuspid regurgitation is common in patients with severe degenerative mitral regurgitation. However, the evidence base insufficient to inform a decision about whether perform tricuspid-valve repair during mitral-valve surgery who have moderate tricuspid or less-than-moderate annular dilatation. We randomly assigned 401 were undergoing for receive procedure without annuloplasty (TA). The primary 2-year end point was composite of reoperation regurgitation, progression by two grades from...
Patients with brain injury who are unresponsive to commands may perform cognitive tasks that detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as motor dissociation, has not been systematically studied in a large cohort of persons disorders consciousness.
There is increasing interest among the general public and medical community in role of religion medicine. Polls indicate that U.S. population highly religious; most people believe heaven hell,1 healing power prayer,2 capacity faith to aid recovery from disease.3 The popular press has published many articles which religious practice have been said promote comfort, healing, or both. A report 77 percent hospitalized patients wanted physicians consider their spiritual needs consistent with this...
PURPOSE: To evaluate the toxicity, efficacy, and pharmacokinetics of docetaxel when combined with oral estramustine dexamethasone in a phase I study patients progressive metastatic androgen-independent prostate cancer. PATIENTS AND METHODS: Thirty-four men were stratified into minimally pretreated (MPT) extensively (EPT) groups. Estramustine 280 mg PO tid was administered 1 hour before or 2 hours after meals on days through 5, escalated doses from 40 to 80 mg/m day 2. Treatment repeated...
Stroke is considered the second most common cause of dementia, but magnitude risk posed by stroke has not been fully clarified. The aim this study was to determine long-term developing dementia after onset in a hospitalized cohort. We prospectively examined 185 nondemented patients aged ≥60 years with ischemic and 241 age-matched controls without from same community using neurologic, neuropsychological, functional assessments given annually. Using criteria modified DSM-III-R, we diagnosed...