A5102786148- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neonatal and fetal brain pathology
- Neuroscience and Neuropharmacology Research
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- EEG and Brain-Computer Interfaces
- Infectious Encephalopathies and Encephalitis
- Pharmaceutical studies and practices
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Fetal and Pediatric Neurological Disorders
- Diet, Metabolism, and Disease
- Cerebrospinal fluid and hydrocephalus
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological and metabolic disorders
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Cytomegalovirus and herpesvirus research
- Digestive system and related health
- Neonatal Health and Biochemistry
- Neurological disorders and treatments
- Ion Transport and Channel Regulation
- Tuberous Sclerosis Complex Research
- Electrolyte and hormonal disorders
University of Chicago
2020-2025
University of Chicago Medical Center
2022
Nationwide Children's Hospital
2021
Mayo Clinic
2021
University of Colorado Anschutz Medical Campus
2021
Cornell University
2021
Hospices Civils de Lyon
2020
Icahn School of Medicine at Mount Sinai
2020
Eisai (United States)
2020
Children's Hospital of Los Angeles
2016-2019
The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, approaches for classifying seizures forms of epilepsy. Generalized focal are redefined as occurring in rapidly engaging bilaterally distributed networks (generalized) within limited to one hemisphere either discretely localized or more widely (focal). generalized is simplified. No natural classification exists; should be described according their manifestations...
The International League Against Epilepsy (ILAE) Classification of the Epilepsies has been updated to reflect our gain in understanding epilepsies and their underlying mechanisms following major scientific advances that have taken place since last ratified classification 1989. As a critical tool for practicing clinician, epilepsy must be relevant dynamic changes thinking, yet robust translatable all areas globe. Its primary purpose is diagnosis patients, but it also research, development...
Whether febrile status epilepticus (FSE) produces hippocampal sclerosis (HS) and temporal lobe epilepsy (TLE) has long been debated. Our objective is to determine whether FSE acute injury that evolves HS.FEBSTAT 2 affiliated studies prospectively recruited 226 children aged 1 month 6 years with controls simple seizures. All had magnetic resonance imaging (MRI), follow-up MRI was obtained approximately year later in the majority. Visual interpretation by neuroradiologists informed only of...
国際抗てんかん連盟(ILAE)は,1989年の前回分類以降の大きな科学的進歩によっててんかんやその発症機序に関する理解が深まったことをうけ,今回てんかん分類を改訂するに至った。てんかん分類は臨床医に不可欠なツールとして,考え方の変化に関連し変動するものでなければならないが,同時に確固たるものでかつ全世界で翻訳可能なものでなければならない。てんかん分類の第一の目的は患者の診断であるが,てんかんの研究,治療法の開発,世界中のコミュニケーションにおいても重要である。今回の新たな分類は,パブリック・コメントを募集するために2013年に提出した初案に端を発しており,数回にわたる協議を経ててんかんに関わる世界各国の人々からの幅広い意見を組み込んで改訂されたものである。この分類には3つのレベルがある。最初のレベルは「発作型」診断であり,2017年ILAE発作分類の定義に基づいて患者がてんかん発作を有していることを前提としている。発作型診断の次のステップは「てんかん病型」診断であり,焦点てんかん,全般てんかん,全般焦点合併てんかん,病型不明てんかんのいずれかに分類される。3つ目のレベルは「てんか...
To evaluate the effectiveness, tolerability, and adverse effects of ketogenic diet in infants with refractory epilepsy.A retrospective review 32 who had been treated at a large metropolitan institution.Most (71%) were able to maintain strong ketosis. The overall effectiveness was similar that reported literature for older children; 19.4% became seizure-free, an additional 35.5% >50% reduction seizure frequency. particularly effective patients infantile spasms/myoclonic seizures. There...
To elucidate the presence and potential involvement of brain inflammation cell death in neurological morbidity intractable seizures childhood epilepsy, we quantified death, astrocyte proliferation, microglial activation cytokine release tissue from patients who underwent epilepsy surgery.Cortical was collected thirteen with due to focal cortical dysplasia (6), encephalomalacia (5), Rasmussen's encephalitis (1) or mesial temporal lobe (1). Sections were processed for immunohistochemistry...
The FEBSTAT study is a prospective that seeks to determine the acute and long-term consequences of febrile status epilepticus (FSE) in childhood.From 2003 2010, 199 children age 1 month 5 years presenting with FSE (>30 minutes) were enrolled within 72 hours episode. Of these, 191 had imaging emphasis on hippocampus. All MRIs reviewed by 2 neuroradiologists blinded clinical details. A group 96 first simple FS who imaged using similar protocol served as controls.A total 22 (11.5%) definitely...
Summary Purpose: In a prospective study, Consequences of Prolonged Febrile Seizures in Childhood (FEBSTAT), we determined the frequency human herpesvirus (HHV)‐6 and HHV‐7 infection as cause febrile status epilepticus (FSE). Methods: Children ages 1 month to 5 years presenting with FSE were enrolled within 72 h received comprehensive assessment including specimens for HHV‐6 HHV‐7. The presence HHV‐6A, HHV‐6B, or DNA RNA (amplified across spliced junction) using quantitative polymerase chain...
In prior studies of febrile seizures (FSs), prolonged FSs were defined, absent empirical evidence, as lasting 10 or 15 minutes more. We assessed the distribution FS duration in a cohort with first FSs, and association between baseline characteristics children.
Summary: There are eight syndromes currently recognized by the International League Against Epilepsy (ILAE) that would fit original operational definition of idiopathic generalized epilepsy (IGE) syndromes, including benign myoclonic in infancy; with febrile seizures plus, an entity evolution; absences; myoclonic‐astatic seizures; childhood absence epilepsy; juvenile and tonic–clonic only. All these can be easily diagnosed when distinctive features present. In some cases, such not present or...
Summary: Purpose: To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut‐1 DS). Methods: Twenty children with clinical laboratory Glut‐1 DS were evaluated. Age at diagnosis, classification, response to treatment determined by chart review. Thirty‐two continuous 24‐h EEG monitoring sessions reports 42 routine studies assessed. Results: diagnosis was between 4 weeks 18 months (mean, 5 months). Seizure generalized tonic or...
To evaluate the efficacy and tolerability of adjunctive levetiracetam in very young children (aged 1 month to <4 years) with partial-onset seizures inadequately controlled one or two antiepileptic drugs. This multicenter, double-blind, randomized, placebo-controlled study consisted a 48-h inpatient baseline video-EEG (electroencephalography) 5-day treatment period (1-day up-titration; evaluation last 2 days). Children who experienced at least during were randomized either [40 mg/kg/day (age...
Summary Purpose: Parents often expect immediate seizure improvement after starting the ketogenic diet (KD) for their children. The purpose of this study was to determine typical time reduction as well which it unlikely be helpful in those children started on KD. Methods: Records all KD at Johns Hopkins Hospital, Baltimore (n = 83) and Children's Memorial Chicago 35) from November 2003 December 2006 were examined first day seizures reportedly improved. Results: Of 118 KD, 99 (84%) had...
The terms "electrical status epilepticus during sleep (ESES)" and "continuous spikes waves (CSWS)" have been used interchangeably when referring to related but different concepts. In addition, the quantification of epileptiform activity has not standardized, approaches used. aim this study was evaluate extent which pediatric neurologists epileptologists use a homogeneous terminology conceptualization in CSWS ESES characterize current understanding these conditions.
Summary Purpose: Febrile status epilepticus (FSE) has been associated with hippocampal injury and subsequent sclerosis (HS) temporal lobe epilepsy. The FEBSTAT study was designed to prospectively examine the association between prolonged febrile seizures development of HS epilepsy, one most controversial issues in We report on baseline phenomenology final cohorts as well detailed aims methodology. Methods: “Consequences Prolonged Seizures Childhood” (FEBSTAT) is a prospective, multicenter...
Summary Objective Treatment of seizures varies by region, with no standard emergency treatment protocol. Febrile status epilepticus ( FSE ) is often a child's first seizure; therefore, families are rarely educated about treatment. Methods From 2002 to 2010, 199 subjects, age 1 month 6 years, were recruited as part prospective, multicenter study consequences , which was defined febrile seizure or series lasting >30 min. The patients' charts reviewed. No standardized protocol implemented...
Our aim was to explore the association between plasma cytokines and febrile status epilepticus (FSE) in children, as well their potential biomarkers of acute hippocampal injury.Analysis performed on residual samples children with FSE (n = 33) part Consequences Prolonged Febrile Seizures Childhood study (FEBSTAT) compared fever 17). Magnetic resonance imaging (MRI) obtained FEBSTAT within 72 h FSE. Cytokine levels ratios antiinflammatory versus proinflammatory without T2 hyperintensity were...
<h3>ABSTRACT</h3> <h3>Objective:</h3> The FEBSTAT (Consequences of Prolonged Febrile Seizures) study is prospectively addressing the relationships among serial EEG, MRI, and clinical follow-up in a cohort children followed from time presentation with febrile status epilepticus (FSE). <h3>Methods:</h3> We recruited 199 FSE within 72 hours presentation. Children underwent detailed history, physical examination, EEG hours. All EEGs were read by 2 teams then conferenced. Associations abnormal...
Summary Objective Infantile spasms ( IS ) represent a severe epileptic encephalopathy presenting in the first 2 years of life. Recommended first‐line therapies (hormonal therapy or vigabatrin) often fail. We evaluated response to second treatment for children whom initial failed produce both clinical remission and electrographic resolution hypsarhythmia whether time was related outcome. Methods The National Spasms Consortium established multicenter, prospective database enrolling infants...
Abstract Objective This study was undertaken to determine whether hippocampal T2 hyperintensity predicts sequelae of febrile status epilepticus, including atrophy, sclerosis, and mesial temporal lobe epilepsy. Methods Acute magnetic resonance imaging (MRI) obtained within a mean 4.4 (SD = 5.5, median 2.0) days after on >200 infants with follow‐up MRI at approximately 1, 5, 10 years. Hippocampal size, morphology, signal intensity were scored visually by neuroradiologists blinded clinical...
To report the authors' experience with diagnosis and management of Dravet syndrome, or severe myoclonic epilepsy in infancy, era commercially available genetic testing, authors performed a retrospective study 16 patients diagnosed syndrome at tertiary care pediatric center. They analyzed their clinical presentation, electroencephalographic findings, (SCN1A gene) results, treatment responses compared findings to previous reports. The presented all previously described characteristics...