A5025489238- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Metabolism and Genetic Disorders
- Pharmaceutical studies and practices
- Ion channel regulation and function
- Diet and metabolism studies
- Porphyrin Metabolism and Disorders
- Pharmacogenetics and Drug Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Genetics and Neurodevelopmental Disorders
- Infectious Encephalopathies and Encephalitis
- Neonatal Health and Biochemistry
- Neonatal and fetal brain pathology
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- Genomics and Rare Diseases
- Anesthesia and Sedative Agents
- Mitochondrial Function and Pathology
- Adenosine and Purinergic Signaling
- Cardiac electrophysiology and arrhythmias
- Schizophrenia research and treatment
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
Western Infirmary
2013-2025
University of Glasgow
2014-2025
University College London
2001-2022
Southbank Centre
2017-2022
Heidelberg University
2022
National Hospital for Neurology and Neurosurgery
2001-2022
University of Southern Denmark
2022
University Medical Center Utrecht
2022
University Hospital Heidelberg
2022
Columbia University Irving Medical Center
2021
More than 30 percent of patients with epilepsy have inadequate control seizures drug therapy, but why this happens and whether it can be predicted are unknown. We studied the response to antiepileptic drugs in newly diagnosed identify factors associated subsequent poor seizures.We prospectively 525 (age, 9 93 years) who were given a diagnosis, treated, followed up at single center between 1984 1997. Epilepsy was classified as idiopathic (with presumed genetic basis), symptomatic (resulting...
The International League Against Epilepsy (ILAE) Commission on Classification and Terminology has revised concepts, terminology, approaches for classifying seizures forms of epilepsy. Generalized focal are redefined as occurring in rapidly engaging bilaterally distributed networks (generalized) within limited to one hemisphere either discretely localized or more widely (focal). generalized is simplified. No natural classification exists; should be described according their manifestations...
Summary To improve patient care and facilitate clinical research, the International League Against Epilepsy (ILAE) appointed a Task Force to formulate consensus definition of drug resistant epilepsy. The overall framework has two “hierarchical” levels: Level 1 provides general scheme categorize response each therapeutic intervention, including minimum dataset knowledge about intervention that would be needed; 2 core epilepsy using set essential criteria based on categorization (from 1)...
<h3>Importance</h3> A study published in 2000 showed that more than one-third of adults with epilepsy have inadequate control seizures antiepileptic drugs (AEDs). This evaluates overall treatment outcomes light the introduction 1 dozen new AEDs past 2 decades. <h3>Objective</h3> To assess long-term outcome patients newly diagnosed and treated epilepsy. <h3>Design, Setting, Participants</h3> longitudinal observational cohort was conducted at Epilepsy Unit Western Infirmary Glasgow, Scotland....
To delineate the temporal patterns of outcome and to determine probability seizure freedom with successive antiepileptic drug regimens in newly diagnosed epilepsy.Patients whom epilepsy was first prescribed between July 1, 1982, April 2006, were followed up until March 31, 2008. Outcomes categorized into 4 patterns: (A) early sustained freedom; (B) delayed but (C) fluctuation periods relapse; (D) never attained. Probability compared. Seizure defined as no seizures for ≥1 year.A total 1,098...
Purpose: To pool data from four published case–control studies of sudden unexpected death in epilepsy (SUDEP) with live controls, to increase the power determine risk factors. Methods: Case–control United States, Sweden, Scotland, and England were combined. SUDEP was defined as (1) a history (>1 epileptic seizure during period <5 years); (2) occurring suddenly; (3) (i.e., no life-threatening illness); (4) remained unexplained after all investigative efforts, including autopsy. Definite...
<b>Objective: </b> We report the results of a prospective study efficacy and tolerability levetiracetam, new antiepileptic drug with unique mechanism action, in comparison controlled-release carbamazepine as first treatment newly diagnosed epilepsy. <b>Methods: Adults ≥2 partial or generalized tonic–clonic seizures previous year were randomly assigned to levetiracetam (500 mg twice daily, n = 288) (200 291) multicenter, double-blind, noninferiority, parallel-group trial. If seizure occurred...
Summary: Purpose: To investigate the interaction among efficacy, tolerability, and overall effectiveness of first antiepileptic drug (AED) in patients with newly diagnosed epilepsy. Methods: The 470 were diagnosed, treated followed up from January 1984 at a single center. Outcome was classified as seizure freedom for least last year or failure initial treatment because inadequate control, adverse events, other reasons. Results: Overall, 47% became seizure‐free prescribed AED. A higher...
Diagnosing refractory epilepsy would facilitate referral for specialist pharmacological review and early consideration of surgery. An outcomes study was undertaken in an unselected cohort newly diagnosed patients to determine the number antiepileptic drug (AED) regimens needed be failed before could designated as pharmacoresistant. Between July 1982 May 2001, 780 adolescents adults prescribed their first AED at Western Infirmary Glasgow, Scotland provided longitudinal data suitable analysis....
Summary Purpose Autoantibodies to specific neurologic proteins are associated with subacute onset encephalopathies, which often present seizures that poorly controlled by conventional antiepileptic drugs (AEDs). Previous cross‐sectional studies have found antibodies in a small proportion of people established epilepsy, but these investigations seldom included patients recent diagnosis. Methods We screened two large epilepsy cohorts investigate the prevalence multiple autoantibodies adult...
To provide information on the effect of coronavirus disease 2019 (COVID-19) pandemic people with epilepsy and consensus recommendations how to best possible care for while avoiding visits urgent facilities hospitalizations during novel pandemic.The authors developed statements in 2 sections. The first was "How should we/clinicians modify our clinical pathway COVID-19 pandemic?" second "What general advice we give this crisis? individually scored a scale -10 (strongly disagree) +10 agree)....