A5074578462- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Intensive Care Unit Cognitive Disorders
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Pharmacological Effects and Toxicity Studies
- Peripheral Neuropathies and Disorders
- COVID-19 and Mental Health
- Sepsis Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Neural dynamics and brain function
- Cerebrospinal fluid and hydrocephalus
- Infectious Encephalopathies and Encephalitis
- Clinical Reasoning and Diagnostic Skills
- Autoimmune Neurological Disorders and Treatments
- Palliative Care and End-of-Life Issues
- Neonatal and fetal brain pathology
- SARS-CoV-2 and COVID-19 Research
- Neurobiology of Language and Bilingualism
Sorbonne Université
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Pitié-Salpêtrière Hospital
2015-2025
Inserm
2016-2025
Institut du Cerveau
2016-2025
Centre National de la Recherche Scientifique
2013-2025
Institut de Psychiatrie et Neurosciences de Paris
2021-2025
Columbia University
2013-2024
Athinoula A. Martinos Center for Biomedical Imaging
2024
Harvard University
2008-2024
Can conscious processing be inferred from neurophysiological measurements? Some models stipulate that the active maintenance of perceptual representations across time requires consciousness. Capitalizing on this assumption, we designed an auditory paradigm evaluates cerebral responses to violations temporal regularities are either local in or global several seconds. Local led early response cortex, independent attention presence a concurrent visual task, whereas late and spatially...
Patients with acquired brain injury and acute or prolonged disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions on coma other DoC is limited but accumulating. This guideline provides the state-of-the-art evidence regarding diagnosis DoC, summarizing data from bedside examination techniques, functional neuroimaging electroencephalography (EEG).Sixteen members European Academy Neurology (EAN) Scientific Panel Coma Chronic Disorders Consciousness,...
In recent years, numerous electrophysiological signatures of consciousness have been proposed. Here, we perform a systematic analysis these electroencephalography markers by quantifying their efficiency in differentiating patients vegetative state from those minimally conscious or state. Capitalizing on review previous experiments and current theories, identify series measures that can be organized into four dimensions: (i) event-related potentials versus ongoing activity; (ii) local...
Dynamic patterns of brain activity at rest distinguish conscious and unconscious states in humans.
Brain activation in response to spoken motor commands can be detected by electroencephalography (EEG) clinically unresponsive patients. The prevalence and prognostic importance of a dissociation between commanded behavior brain the first few days after injury are not well understood.
Determining the state of consciousness in patients with disorders is a challenging practical and theoretical problem. Recent findings suggest that multiple markers brain activity extracted from EEG may index human brain. Furthermore, machine learning has been found to optimize their capacity discriminate different states clinical practice. However, it unknown how dependable these are face signal variability because configurations, protocols subpopulations centres encountered In this study we...
Little is known about the neuronal substrates of neuropsychiatric symptoms associated with COVID-19 and their evolution during course disease. We aimed at describing longitudinal brain metabolic pattern in COVID-19-related encephalopathy using 18F-FDG-PET/CT.Seven patients variable clinical presentations were explored thrice 18F-FDG-PET/CT, once acute phase, 1 month later 6 months after onset. PET images analysed voxel-wise regions-of-interest approaches comparison 32 healthy...
Patients with brain injury who are unresponsive to commands may perform cognitive tasks that detected on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). This phenomenon, known as motor dissociation, has not been systematically studied in a large cohort of persons disorders consciousness.
Probing consciousness in noncommunicating patients is a major medical and neuroscientific challenge. While standardized expert behavioral assessment of constitutes mandatory step, this clinical evaluation stage often difficult doubtful, calls for complementary measures which may overcome its inherent limitations. Several functional brain imaging methods are currently being developed within perspective, including fMRI cognitive event-related potentials (ERPs). We recently designed an original...
Abstract Coma and disordered consciousness are common manifestations of acute neurological conditions among the most pervasive challenging aspects treatment in neurocritical care. Gaps exist patient assessment, outcome prognostication, directed specifically at improving cognitive recovery. In 2019, Neurocritical Care Society (NCS) launched Curing Campaign order to address “grand challenge” management patients with coma decreased consciousness. One first steps was bring together a Scientific...
We here aimed at characterizing heart-brain interactions in patients with disorders of consciousness. tested how this information impacts data-driven classification between unresponsive and minimally conscious patients.A cohort 127 vegetative state/unresponsive wakefulness syndrome (VS/UWS; n = 70) state (MCS; 57) were presented the local-global auditory oddball paradigm, which distinguishes 2 levels processing: short-term deviation local regularities global long-term rule violations. In...
Neurological manifestations of coronavirus disease 19 (COVID-19) such as encephalitis and seizures have been reported increasingly, but our understanding COVID-19-related brain injury is still limited. Herein we describe prefrontal involvement in a patient with COVID-19 who presented prior anosmia, raising the question potential trans-olfactory bulb invasion.
Abstract Severe brain injuries can lead to long-lasting disorders of consciousness (DoC) such as vegetative state/unresponsive wakefulness syndrome (VS/UWS) or minimally conscious state (MCS). While behavioral assessment remains the gold standard determine state, EEG has proven be a promising complementary tool monitor effect new therapeutics. Encouraging results have been obtained with invasive electrical stimulation brain, and recent studies identified transcranial direct current (tDCS) an...
The prognosis value of early clinical diagnosis consciousness impairment is documented by an extremely limited number studies, whereas it may convey important information to guide medical decisions.We aimed at determining if patients diagnosed stage (<90 days after brain injury) as being in the minimally conscious state (MCS) have a better than vegetative state/Unresponsive Wakefulness syndrome (VS/UWS), independent care limitations or withdrawal decisions.Patients hospitalized ICUs...