Vincent Perlbarg
A5035205639- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Trauma and Emergency Care Studies
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurobiology of Language and Bilingualism
- Psychosomatic Disorders and Their Treatments
- Neurosurgical Procedures and Complications
- Sepsis Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Neurodegenerative Diseases
- Blind Source Separation Techniques
- Medical Imaging and Analysis
- Tensor decomposition and applications
- Cerebrospinal fluid and hydrocephalus
- Transcranial Magnetic Stimulation Studies
- Respiratory Support and Mechanisms
- Alzheimer's disease research and treatments
- Radiation Dose and Imaging
Assistance Publique – Hôpitaux de Paris
2012-2025
University of Cambridge
2024
Genomic Vision (France)
2024
Addenbrooke's Hospital
2024
Sorbonne Université
2014-2023
Brain (Germany)
2023
Sorbonne University Abu Dhabi
2023
Institut du Cerveau
2013-2022
Inserm
2013-2022
Centre National de la Recherche Scientifique
2015-2022
The ‘default network’ is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown it possible to reliably identify this network in the absence any task, by resting state functional magnetic resonance imaging connectivity analyses healthy volunteers. However, significance these spontaneous brain fluctuations...
Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis impaired consciousness NREM associated with an increased modularity of activity. Cerebral connectivity was quantified resting-state functional magnetic resonance imaging times series acquired 13 healthy volunteers wakefulness and sleep. The analysis revealed a modification hierarchical organization large-scale networks into...
Existing methods to predict recovery after severe traumatic brain injury lack accuracy. The aim of this study is determine the prognostic value quantitative diffusion tensor imaging (DTI).In a multicenter study, authors prospectively enrolled 105 patients who remained comatose at least 7 days injury. Patients underwent magnetic resonance imaging, including DTI in 20 preselected white matter tracts. were evaluated 1 yr with modified Glasgow Outcome Scale. A composite score was constructed for...
The objective of the study is to test whether multimodal magnetic resonance imaging can provide a reliable outcome prediction clinical status, focusing on consciousness at 1 year after severe traumatic brain injury (TBI).Single center prospective cohort with consecutive inclusions.Critical Care Neurosurgical Unit university hospital.Forty-three TBI patients not responding simple orders sedation cessation and 15 healthy controls.A combining morphologic sequences, diffusion tensor (DTI), H...
Reduced dopamine input to cortical and subcortical brain structures, particularly those in the sensorimotor network, is a hallmark of Parkinson's disease (PD). The extent which dysfunction affects connectivity within this other networks remains be investigated. purpose study was measure anatomical functional groups PD patients controls determine whether deficits cortico–basal ganglia thalamocortical system could attributed PD, connections. A neuroimaging paradigm involving diffusion‐weighted...
Abstract Severe cognitive impairment involving multiple domains can occur early during the course of sclerosis (MS). We investigated resting state functional connectivity changes in large‐scale brain networks and related structural damage underlying dysfunction patients with MS. Patients relapsing MS (3–5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), abnormal...
Heart rate has natural fluctuations that are typically ascribed to autonomic function. Recent evidence suggests conscious processing can affect the timing of heartbeat. We hypothesized heart is modulated by and therefore dependent on attentional focus. To test this, we leverage observation neural processes synchronize between subjects presenting an identical narrative stimulus. As predicted, find significant inter-subject correlation (ISC-HR) when presented with auditory or audiovisual...
As gene-based therapies may soon arise for patients with spinocerebellar ataxia (SCA), there is a critical need to identify biomarkers of disease progression effect sizes greater than clinical scores, enabling trials smaller sample sizes.We enrolled unique cohort SCA1 (n = 15), SCA2 12), SCA3 20) and SCA7 10) 24 healthy controls similar age, sex body mass index. We collected longitudinal imaging data at baseline follow-up (mean interval months). performed both manual automated volumetric...
Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...
The early prediction of consciousness recovery from traumatic brain injury (TBI) is crucial to make decisions about the appropriate use prolonged intensive care. Diffusion tensor imaging (DTI) has been proposed as a biomarker white matter that could be used in classification purpose. Instead region-of-interest-based approach, we applied voxel-based approaches (voxel-based DTI and tract-based spatial statistics) on 30 patients with TBI identify, without any prior, regions were specifically...
Prognostication in comatose survivors of cardiac arrest is a major clinical challenge. The authors' objective was to determine whether an assessment with diffusion tensor imaging, brain magnetic resonance imaging sequence, increases the accuracy 1 yr functional outcome prediction survivors.Prospective, observational study two intensive care units. Fifty-seven underwent imaging. Fractional anisotropy (FA), value, measured predefined white matter regions, and apparent coefficient assessed grey...
Purpose To assess whether early brain functional connectivity is associated with recovery 1 year after cardiac arrest (CA). Materials and Methods Enrolled in this prospective multicenter cohort were 46 patients who comatose CA. Principal outcome was cerebral performance category at 12 months, favorable (FO) defined as or 2. All participants underwent multiparametric structural magnetic resonance (MR) imaging less than 4 weeks Within- between-network measured dorsal attention network (DAN),...
The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, are underrepresented TBI research. Therefore, we aimed to provide an overview health-care utilization, and six-month outcomes after their determinants who sustained TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. In-hospital post-hospital care utilization were...
Isolated rapid eye movement sleep behaviour disorder (iRBD) is a characterized by the loss of muscle atonia and appearance abnormal movements vocalizations during sleep. It strong marker incipient synucleinopathy such as dementia with Lewy bodies Parkinson's disease. Patients iRBD already show brain changes that are reminiscent manifest synucleinopathies including atrophy. However, mechanisms underlying development this atrophy remain poorly understood. In study, we performed cutting-edge...
<h3>BACKGROUND AND PURPOSE:</h3> Extensive white matter damage has been documented in patients with severe traumatic brain injury, yet how this evolves the long term is not well understood. We used DTI to study changes at 5 years after injury. <h3>MATERIALS METHODS:</h3> There were 8 healthy control participants and 13 injury who enrolled a prospective observational study, which included clinical assessment MR imaging acute setting (< 6 weeks) 2 Only subjects mild moderate disability or...
The growing number of modalities (e.g. multi-omics, imaging and clinical data) characterizing a given disease provides physicians statisticians with complementary facets reflecting the process but emphasizes need for novel statistical methods data analysis able to unify these views. Such sets are indeed intrinsically structured in blocks, where each block represents set variables observed on group individuals. Therefore, classical tools cannot be applied without altering their organization,...