A5056123952- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Peripheral Neuropathies and Disorders
- Biotin and Related Studies
- Protein Tyrosine Phosphatases
- Systemic Sclerosis and Related Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Emergency and Acute Care Studies
- Olfactory and Sensory Function Studies
- Dermatological and Skeletal Disorders
- Monoclonal and Polyclonal Antibodies Research
- Systemic Lupus Erythematosus Research
- Health, Medicine and Society
- Fungal Infections and Studies
- Acute Lymphoblastic Leukemia research
- Vitamin D Research Studies
- Receptor Mechanisms and Signaling
- Vestibular and auditory disorders
- Sleep and Wakefulness Research
- Healthcare Systems and Practices
- T-cell and B-cell Immunology
- Hepatitis B Virus Studies
- Social Sciences and Governance
Assistance Publique – Hôpitaux de Paris
2014-2021
Sorbonne Université
2014-2021
Pitié-Salpêtrière Hospital
2014-2021
Observatoire Français de la Sclérose en Plaques
2021
Hôpital Saint-Antoine
2015
Hôpital Tenon
2014
Institut de Psychiatrie et Neurosciences de Paris
2014
Fondation Ophtalmologique Adolphe de Rothschild
2010
Fondation de Rothschild
2009
Hôpital Avicenne
2001
Abstract Severe cognitive impairment involving multiple domains can occur early during the course of sclerosis (MS). We investigated resting state functional connectivity changes in large‐scale brain networks and related structural damage underlying dysfunction patients with MS. Patients relapsing MS (3–5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), abnormal...
Despite the high comorbidity of anxiety and depression in people with multiple sclerosis (MS), little is known about their inter-relationships. Both involve emotional perturbations way which emotions are processed likely central to both. The aim current study was explore relationships between domains mood, processing coping analyse how affects coping, processing, balance MS.A cross-sectional questionnaire involving 189 MS a confirmed diagnosis recruited from three French hospitals. Study...
Objective Using positron emission tomography (PET) with [ 11 C]flumazenil ([ C]FMZ), an antagonist of the central benzodiazepine site located within GABA A receptor, we quantified and mapped neuronal damage in gray matter (GM) patients multiple sclerosis (MS) at distinct disease stages. We investigated relationship between white (WM) lesions evaluated clinical relevance this PET metric. Methods cohort 18 MS (9 progressive 9 relapsing‐remitting) was compared to healthy controls underwent...
To evaluate sleepiness and central hypersomnia in multiple sclerosis (MS)-associated fatigue, we performed long-term polysomnography patients with MS healthy controls.Patients controls completed questionnaires on sleep, sleepiness, depression. They underwent nocturnal polysomnography, sleep latency tests, bed rest 24-hour polysomnography. Patients were divided into 3 groups (fatigue fatigue no neither nor sleepiness).Among 44 MS, 19 (43.2%) had 15 (34%) only 10 (22.7%) sleepiness. Compared...
Few cases of human papillomavirus (HPV) diseases have been reported in multiple sclerosis (MS) patients treated with fingolimod. We describe a case series 16 MS (11 women, 5 men) developing HPV lesions after the onset fingolimod, without previous history. Fingolimod had to be discontinued six patients. Six received vaccination for HPV, good tolerance. Our report highlights that systematic screening and discussion about before fingolimod are crucial. In occurrence during treatment,...
Disabled multiple sclerosis (MS) patients often need intervention of specialists, resulting in a complex organization care. How this multidisciplinary care should be organized and structured has not been studied.The objective article is to address the effectiveness an integrated approach versus usual MS patients.This prospective, randomized, controlled, monocentric clinical trial patients. Two treatment strategies were compared: (i) (IMD) approach, consisting half-day individually tailored...
Report and identify relationship between high doses of biotin a potential pro-inflammatory effect in progressive multiple sclerosis (PMS).