A5004199452- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Advanced Neuroimaging Techniques and Applications
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Systemic Sclerosis and Related Diseases
- RNA regulation and disease
- Medical Imaging Techniques and Applications
- Viral Infections and Immunology Research
- Radiopharmaceutical Chemistry and Applications
- Cerebral Venous Sinus Thrombosis
- Cerebrospinal fluid and hydrocephalus
- SARS-CoV-2 and COVID-19 Research
- Plant Virus Research Studies
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Nerve injury and regeneration
- Medical Image Segmentation Techniques
- Alzheimer's disease research and treatments
- Immunotherapy and Immune Responses
- Cell Image Analysis Techniques
- Hereditary Neurological Disorders
Sorbonne Université
2016-2025
Allen Institute for Brain Science
2018-2025
Institut du Cerveau
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Pitié-Salpêtrière Hospital
2016-2025
Inserm
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Saint-Antoine
2015-2024
Institut national de recherche en informatique et en automatique
2024
Centre Hospitalier Universitaire de Rennes
2024
The oligodendrocyte is the myelin-forming cell in central nervous system. Despite close interaction between axons and oligodendrocytes, there little evidence that neurons influence myelinogenesis. On contrary, newly differentiated which mature culture total absence of neurons, synthesize myelin-specific constituents oligodendrocytes vivo even form myelin-like figures. Neuronal electrical activity may be required, however, for appropriate formation myelin sheath. To investigate role on...
<h3>Importance</h3> Risk factors associated with the severity of coronavirus disease 2019 (COVID-19) in patients multiple sclerosis (MS) are unknown. Disease-modifying therapies (DMTs) may modify risk developing a severe COVID-19 infection, beside identified such as age and comorbidities. <h3>Objective</h3> To describe clinical characteristics outcomes MS identify severity. <h3>Design, Setting, Participants</h3> The Covisep registry is multicenter, retrospective, observational cohort study...
Quantitative in vivo imaging of myelin loss and repair patients with multiple sclerosis (MS) is essential to understand the pathogenesis disease evaluate promyelinating therapies. Selectively binding central nervous system white matter, Pittsburgh compound B ([11 C]PiB) can be used as a positron emission tomography (PET) tracer explore dynamics MS.Patients active relapsing-remitting MS (n = 20) healthy controls 8) were included longitudinal trial combining PET [11 C]PiB magnetic resonance...
Background Choroid plexuses (CPs) have been suggested as a key gateway for inflammation in experimental autoimmune encephalitis, but vivo evidence of their involvement multiple sclerosis (MS) is lacking. Purpose To assess CP volumetric and inflammatory changes patients with MS versus healthy control participants. Materials Methods This was secondary analysis 97 (61 relapsing-remitting [RRMS] 36 progressive MS) 44 participants who participated three prospective 3.0-T brain MRI studies between...
Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of dura mater, where they ensure waste product elimination immune surveillance brain tissues. Whether MLVs exist anterior part murine human skull how connect with glymphatic system extracranial lymphatics remained unclear. Here, we used light-sheet fluorescence microscopy (LSFM) imaging mouse whole-head preparations after OVA-A555 tracer injection into cerebrospinal fluid (CSF) performed real-time...
To determine the prognostic value of persisting neuroinflammation in multiple sclerosis (MS) lesions, we developed a 18 kDa-translocator-protein-positron emission tomography (PET) -based classification each lesion according to innate immune cell content and localization. We assessed respective predictive phenotype diffuse inflammation on atrophy disability progression over 2 years.Thirty-six people with MS (disease duration 9 ± 6 years; 12 relapsing-remitting, 13 secondary-progressive, 11...
A recent randomized clinical trial concluded that discontinuing medium-efficacy therapy might be a reasonable option for older patients with nonactive multiple sclerosis (MS), but there is lack of data on high-efficacy (HET). In younger patients, the discontinuation natalizumab and fingolimod associated risk rebound disease activity.
Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or lysophosphatidic acid. We show that in the CNS, expression of Edg8/S1P5, a high-affinity S1P receptor, is restricted to oligodendrocytes and expressed throughout development from immature stages mature myelin-forming cell. activation Edg8/S1P5 on O4-positive pre-oligodendrocytes induced process retraction via Rho kinase/collapsin...
Many factors have been shown to promote myelination, but few be inhibitory. Here, we show that polysialylated-neural cell adhesion molecule (PSA-NCAM) can negatively regulate myelin formation. During development, PSA-NCAM is first expressed on all growing fibers; then, axonal expression down-regulated and deposition occurs only PSA-NCAM-negative axons. Similarly, in cocultures of oligodendrocytes neurons, axons initially high, decreases as myelination proceeds. Importantly, if prematurely...
In multiple sclerosis, myelin repair is generally insufficient despite the relative survival of oligodendrocytes within plaques and recruitment oligodendrocyte precursors. Promoting remyelination appears to be a crucial therapeutic challenge. Using newly developed enzymatic index myelination, we screened different neurotrophic factors for their ability enhance myelination. Neurotrophins [NGF, neurotrophin-3 (NT-3), NT-4/5, BDNF], glial cell line-derived factor (GDNF)-related (GDNF,...
To determine long-term treatment (LTT) of neuromyelitis optica (NMO), we retrospectively reviewed therapies 26 patients with NMO followed in five French neurological departments. assess LTT efficacy, the probability relapse free after was analysed. Patients were divided into two groups according to first receiving interferon beta (IFN Group, seven patients) or immunosuppressants (IS 19 patients). The significantly lower IS Group (P =0.0007). From our results, is not recommended, and one best...
Abstract Objective: Imaging of myelin tracts in vivo would greatly improve the monitoring demyelinating diseases such as multiple sclerosis (MS). To date, no imaging technique specifically targets demyelination and remyelination. Recently, amyloid markers related to Congo red have been shown bind central nervous system (CNS) myelin. Here we questioned whether thioflavine‐T derivative 2‐(4′‐methylaminophenyl)‐6‐hydroxybenzothiazole (PIB), which also binds plaques, could serve a marker....
The safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort patients with multiple sclerosis (MS) our knowledge.To collect data MS fingolimod.The Enquête Nationale sur l'Introduction du Fingolimod en Relais au Natalizumab (ENIGM) study, survey-based, observational multicenter study among tertiary referral centers. Participants were for whom switch was planned. Clinical collected on treatment, duration management the washout period (WP),...
Abstract Severe cognitive impairment involving multiple domains can occur early during the course of sclerosis (MS). We investigated resting state functional connectivity changes in large‐scale brain networks and related structural damage underlying dysfunction patients with MS. Patients relapsing MS (3–5 years disease duration) were prospectively assigned to two groups based on a standardized neuropsychological evaluation: (1) cognitively impaired group (CI group, n = 15), abnormal...
The care of multiple sclerosis (MS) in France is based on two complementary interlinked networks: MS expert centers university hospitals and regional networks neurologists. routine use European database for (EDMUS) all those has paved the way constitution a national registry, designated as Observatoire Français de la Sclérose En Plaques (OFSEP). It promotes prospective, standardized, high-quality, multimodal collection data. On June 2018, there were 68.097 files, with 71.1% females,...
Abstract We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, a pooled‐analysis two large cohorts from Italy and France. The association baseline characteristics was assessed by multivariate ordinal‐logistic models pooled fixed‐effect meta‐analysis. 1066 MS 721 France were included. In model, anti‐CD20 therapies significantly associated (OR = 2.05, 95%CI 1.39–3.02, p < 0.001) severity, whereas interferon indicated decreased risk 0.42, 0.18–0.99, 0.047). This confirms...
Objective: To evaluate the effectiveness and tolerance of mycophenolate mofetil (MMF) as a first-line treatment in neuromyelitis optica spectrum disorder (NMOSD). Methods: In all, 67 NMOSD patients treated by MMF therapy, from NOMADMUS cohort were included. A total 65 fulfilled 2015 criteria, 5 myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) positive. Effectiveness was evaluated on percentage continuing MMF, free relapse, pre- post-treatment change annualized relapse rate...