A5042101254- French Urban and Social Studies
- Historical Studies and Socio-cultural Analysis
- Multiple Sclerosis Research Studies
- Historical and Scientific Studies
- Aging, Elder Care, and Social Issues
- Social Sciences and Governance
- History of Science and Medicine
- European Political History Analysis
- Health, Medicine and Society
- Healthcare Systems and Practices
- Cultural Identity and Heritage
- Diverse Historical and Scientific Studies
- American Environmental and Regional History
- Neurogenesis and neuroplasticity mechanisms
- Historical Economic and Social Studies
- Multiculturalism, Politics, Migration, Gender
- Peripheral Neuropathies and Disorders
- Reproductive System and Pregnancy
- Pregnancy and Medication Impact
- Historical Art and Culture Studies
- Global Energy and Sustainability Research
- Neuroscience and Neuropharmacology Research
- Occupational Health and Safety Research
- Water Governance and Infrastructure
- Receptor Mechanisms and Signaling
École des hautes études en sciences sociales
2016-2025
Centre de Recherches Historiques
2014-2024
Centre National de la Recherche Scientifique
2014-2024
Pitié-Salpêtrière Hospital
2015-2024
Sorbonne Université
2015-2024
Inserm
2019-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Observatoire Français de la Sclérose en Plaques
2024
Institut du Cerveau
2019-2023
Health Protection Surveillance Centre
2021
Microglia, the resident immune cells of central nervous system, are key players in healthy brain homeostasis and plasticity. In neurological diseases, such as Multiple Sclerosis, activated microglia either promote tissue damage or favor neuroprotection myelin regeneration. The mechanisms for microglia-neuron communication remain largely unkown. Here, we identify nodes Ranvier a direct site interaction between axons, both mouse human tissues. Using dynamic imaging, highlight preferential...
Immune checkpoint inhibitors (ICIs) are increasingly used in cancer treatment. Their mechanism of action raises the question possible exacerbation preexisting multiple sclerosis (MS). The aim our study was to assess risk increased MS activity, defined by occurrence a relapse and/or new MRI lesion, after ICI initiation. This French multicentric collected retrospective and prospective data on patients with treated ICIs diagnosis. We identified 18 median age 48 years. Three them (17%), all aged...
Epidemiological data reveal that 45% of persons with multiple sclerosis (PwMS) in France are more than 50 years. This population is susceptible to cancer, and this risk may be increased by frequent use immunosuppressive drugs. Consequently, concerns have arisen about the potential cancer PwMS how patients should screened managed terms risk. To develop evidence-based recommendations manage coexistence (MS). The French Group for Recommendations MS collected articles from PubMed university...
Though lacking in public support, the Constitutional Court of South Africa (CCSA) today finds itself a position relative institutional security. At same time, it has built up an enviable reputation among constitutional courts new democracies for technical quality its jurisprudence or legitimacy legal sense. This essay attempts to explain how this situation come about by developing theoretical account relationship between legitimacy, and security, then using interpret CCSA's record from 1995...
We aimed to analyse the response rituximab in a cohort of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) patients with associated disorders. conducted clinical and electrophysiological retrospective monocentric study 28 CIDP patients. Response was defined as (a) five-point increase Medical Research Council sum score or one-point decrease Overall Neuropathy Limitations Scale score, compared at first infusion, (b) discontinuation of, reduced need for, last treatments before...
This article examines how chemists contributed to the technological reorganization in France at end of eighteenth century and beginning nineteenth century, they justified using potentially harmful or polluting processes by stating that this would contribute national prosperity, idea improvement helped legally rhetorically build a production regime disqualified traditional precautionary attitudes certain artisanal industrial processes. resulted establishment new environmental governance...
The purpose of this article is to use the conceptual logic underpinning three main models US Supreme Court decision-making construct a comparative typology constitutional courts, and then show how may be used for further research. To end, explains determinants associated with need reconceptualized purposes. proposed approach generates four ideal-typical each its own characteristic mode. shift from modes means that cannot predict circumstances in which American are likely have explanatory...
Abstract In vertebrates, fast saltatory conduction along myelinated axons relies on the node of Ranvier. How nodes assemble CNS neurons is not yet fully understood. We previously described that node‐like clusters can form prior to myelin deposition in hippocampal GABAergic and are associated with increased velocity. Here, we used a live imaging approach characterize intrinsic mechanisms underlying assembly these myelination. first demonstrated their components partially preassemble membrane...
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Dear Sirs, COVID-19 pandemic due to SARS-CoV2 virus is ongoing, with a fatality rate around 5.4% [1].Neuromyelitis optica spectrum disorders (NMO/SD) rare disabling disease requiring immunosuppressive therapy.The risk of severe remains unknown in NMO/SD.The aim this case-series study describe the prevalence and characteristics NMO/SD patients.We conducted monocentric retrospective caseseries patients highly suspected or proven COVID-19.They fulfilled at least one three NMO diagnostic...
Background: Late-onset neutropenia (LON), defined as an absolute neutrophil count (ANC) < 1500/mm 3 that develops between 4 weeks and 6 months after the last drug administration, is a rare side effect of anti-CD20 drugs including ocrelizumab. Although continuation ocrelizumab LON not contraindicated, risk recurrence well known. Cases: We report three cases recurrent symptomatic agranulocytosis (ANC 500/mm ) occurring under Conclusion: Given availability other treatments, therapeutic...
From the late eighteenth to early nineteenth century, large numbers of artisanal and industrial sectors began be upset by adoption innovative processes, new forms work organization rhythms, which had important consequences for health workers artisans. In 1770s, problem diseases artisans was suddenly a subject debate in medical areas Paris, academies, public opinion. Starting from 1789, there dramatic reversal: lack literature, proliferation accidents, tightening regulations resulted an...