NFDI4DS | UHH-SEMS - Publication Details

Véronique De Keyser

ORCID: 0009-0005-0777-8370

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A5056606450

Research Areas

Traumatic Brain Injury and Neurovascular Disturbances
Traumatic Brain Injury Research
Trauma and Emergency Care Studies
Cardiac Arrest and Resuscitation
Human-Automation Interaction and Safety
Risk and Safety Analysis
Occupational Health and Safety Research
AI-based Problem Solving and Planning
Social Sciences and Governance
Sepsis Diagnosis and Treatment
Education, sociology, and vocational training
Complex Systems and Decision Making
Workplace Health and Well-being
Neurosurgical Procedures and Complications
Job Satisfaction and Organizational Behavior
Employment and Welfare Studies
Stress and Burnout Research
Workaholism, burnout, and well-being
Retirement, Disability, and Employment
Assembly Line Balancing Optimization
Semantic Web and Ontologies
Radiation Dose and Imaging
Cognitive Science and Mapping
Musculoskeletal pain and rehabilitation
Quality and Safety in Healthcare

Antwerp University Hospital
2019-2025

University of Cambridge
2020-2024

Addenbrooke's Hospital
2022-2024

University of Antwerp
2020-2022

University of Groningen
2022

Karolinska Institutet
2022

University of Oslo
2021

Centre Hospitalier Régional et Universitaire de Nancy
2021

Heidelberg University
2021

Oslo University Hospital
2021

Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study

OPENALEX - Publications

Ewout W. Steyerberg Eveline Wiegers Charlie Sewalt András Büki Giuseppe Citerio and 95 more

10.1016/s1474-4422(19)30232-7 article EN The Lancet Neurology 2019-09-12

Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury

OPENALEX - Publications

Benjamin Gravesteijn Daan Nieboer Ari Ercole Hester F. Lingsma David Nelson and 95 more

ObjectiveWe aimed to explore the added value of common machine learning (ML) algorithms for prediction outcome moderate and severe traumatic brain injury.Study Design SettingWe performed logistic regression (LR), lasso regression, ridge with key baseline predictors in IMPACT-II database (15 studies, n = 11,022). ML included support vector machines, random forests, gradient boosting artificial neural networks were trained using same predictors. To assess generalizability predictions, we...

10.1016/j.jclinepi.2020.03.005 article EN cc-by Journal of Clinical Epidemiology 2020-03-20

Surgery versus conservative treatment for traumatic acute subdural haematoma: a prospective, multicentre, observational, comparative effectiveness study

OPENALEX - Publications

Thomas A. van Essen Hester F. Lingsma Dana Pisică Ranjit D. Singh Victor Volovici and 95 more

10.1016/s1474-4422(22)00166-1 article EN The Lancet Neurology 2022-05-05

Occupational stress and burnout in anaesthesia

OPENALEX - Publications

Anne‐Sophie Nyssen Isabelle Hansez Ph. Baele Martine Lamy Véronique De Keyser

10.1093/bja/aeg058 article EN publisher-specific-oa British Journal of Anaesthesia 2003-02-20

Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury

OPENALEX - Publications

Ana Mikolić David van Klaveren Joost Oude Groeniger Eveline Wiegers Hester F. Lingsma and 95 more

Traumatic brain injury (TBI) is a significant cause of disability, but little known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, broad range care pathways, treatment characteristics, outcomes following mild moderate/severe performed mixed-effects regression analyses in prospective multi-center Collaborative European NeuroTrauma Effectiveness Research Brain Injury (CENTER-TBI) study, stratified for severity age, adjusted baseline...

10.1089/neu.2020.7228 article EN cc-by Journal of Neurotrauma 2020-08-25

Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury

OPENALEX - Publications

Esther L. Yuh Sonia Jain Xiaoying Sun Dana Pisică Mark Harris and 95 more

<h3>Importance</h3> A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown be associated outcomes. mild (mTBI; GCS 13-15), distribution and co-occurrence of pathological their prognostic importance are not well understood. <h3>Objective</h3> To identify adverse outcomes after mTBI....

10.1001/jamaneurol.2021.2120 article EN cc-by JAMA Neurology 2021-07-19

Serum metabolome associated with severity of acute traumatic brain injury

OPENALEX - Publications

Ilias Thomas Alex M. Dickens Jussi P. Posti Endre Czeiter Daniel Duberg and 95 more

Complex metabolic disruption is a crucial aspect of the pathophysiology traumatic brain injury (TBI). Associations between this and systemic metabolism their potential prognostic value are poorly understood. Here, we aimed to describe serum metabolome (including lipidome) associated with acute TBI within 24 h post-injury, its relationship severity patient outcome. We performed comprehensive metabolomics study in cohort 716 patients non-TBI reference (orthopedic, internal medicine, other...

10.1038/s41467-022-30227-5 article EN cc-by Nature Communications 2022-05-10

Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study

OPENALEX - Publications

Eveline Wiegers Hester F. Lingsma Jilske Huijben D. James Cooper Giuseppe Citerio and 95 more

10.1016/s1474-4422(21)00162-9 article EN The Lancet Neurology 2021-07-21

Clustering identifies endotypes of traumatic brain injury in an intensive care cohort: a CENTER-TBI study

OPENALEX - Publications

Cecilia Åkerlund Anders Vedel Holst Nino Stocchetti Ewout W. Steyerberg David K. Menon and 95 more

Abstract Background While the Glasgow coma scale (GCS) is one of strongest outcome predictors, current classification traumatic brain injury (TBI) as ‘mild’, ‘moderate’ or ‘severe’ based on this fails to capture enormous heterogeneity in pathophysiology and treatment response. We hypothesized that data-driven characterization TBI could identify distinct endotypes give mechanistic insights. Methods developed an unsupervised statistical clustering model a mixture probabilistic graphs for...

10.1186/s13054-022-04079-w article EN cc-by Critical Care 2022-07-27

Effect of frailty on 6-month outcome after traumatic brain injury: a multicentre cohort study with external validation

OPENALEX - Publications

Stefania Galimberti Francesca Graziano Andrew I.R. Maas Giulia Isernia Fiona Lecky and 95 more

10.1016/s1474-4422(21)00374-4 article EN The Lancet Neurology 2022-01-20

Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury

OPENALEX - Publications

Rebecca Woodrow Stefan Winzeck Andrea I. Luppi Isaac Kelleher-Unger Lennart R. B. Spindler and 85 more

Abstract Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI may be related long-term outcomes but requires further investigation. We compared structural MRI resting state 108 patients with a Glasgow Coma Scale (GCS) of 13–15 normal CT, 76 controls. examined whether acute changes thalamic connectivity were early markers for persistent explored neurochemical...

10.1093/brain/awad056 article EN cc-by Brain 2023-02-22

Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study

OPENALEX - Publications

Thomas A. van Essen Inge A. M. van Erp Hester F. Lingsma Dana Pisică John K. Yue and 95 more

Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation traumatic acute subdural hematoma (ASDH) until recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes primary DC craniotomy.We conducted an analysis centre treatment preference within prospective, multicentre, observational Collaborative European NeuroTrauma...

10.1016/j.eclinm.2023.102161 article EN cc-by EClinicalMedicine 2023-08-09

Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes—an analysis of CENTER-TBI data

OPENALEX - Publications

Chiara Robba Francesca Graziano Edoardo Picetti Cecilia Åkerlund Alberto Addis and 95 more

We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...

10.1007/s00134-024-07324-8 article EN cc-by-nc Intensive Care Medicine 2024-02-20

Time and the Dynamic Control of Behavior

OPENALEX - Publications

Lorraine G. Allan Véronique De Keyser Géry d’Ydewalle André Vandierendonck

Time estimation: mechanisms underlying timing abilities in animals - steady-states and dynamic situations exploring scalar theory with human subjects reponse latencies temporal bisection implications for models brain correlates of time processing motor programming electrophysiological data humans what changes rhythmic performances ageing? the relationship between internal external determinants estimation behaviour new perspective on prospective parallel short duration reproduction meaningful...

10.2307/1423368 article EN The American Journal of Psychology 2000-01-01

Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study

OPENALEX - Publications

Ernest van Veen Mathieu van der Jagt Giuseppe Citerio Nino Stocchetti Diederik Gommers and 95 more

In patients with severe brain injury, withdrawal of life-sustaining measures (WLSM) is common in intensive care units (ICU). WLSM constitutes a dilemma: instituting too early could result death despite the possibility an acceptable functional outcome, whereas delaying unnecessarily burden patients, families, clinicians, and hospital resources. We aimed to describe occurrence timing WLSM, factors associated European ICUs traumatic injury (TBI). The CENTER-TBI Study prospective multi-center...

10.1007/s00134-021-06484-1 article EN cc-by-nc Intensive Care Medicine 2021-08-05

Explaining Outcome Differences between Men and Women following Mild Traumatic Brain Injury

OPENALEX - Publications

Ana Mikolić Joost Oude Groeniger Marina Zeldovich Lindsay Wilson Jeanine E. Roeters van Lennep and 95 more

Men and women differ in outcomes following mild traumatic brain injury (TBI). In the CENTER-TBI study, we previously found that had worse 6-month functional outcome (Glasgow Outcome Score Extended (GOSE)), health-related quality of life (HRQoL), mental health TBI. The aim this study was to investigate whether those differences were mediated by psychiatric history, gender- related sociodemographic variables, or care pathways. We analyzed sex/gender GOSE, generic TBI-specific HRQoL,...

10.1089/neu.2021.0116 article EN cc-by Journal of Neurotrauma 2021-10-07

Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study

OPENALEX - Publications

Cecilia Åkerlund Anders Vedel Holst Shubhayu Bhattacharyay Nino Stocchetti Ewout W. Steyerberg and 95 more

10.1016/s1474-4422(23)00358-7 article EN The Lancet Neurology 2023-11-14

Contrasting Characteristics and Outcomes of Sports-Related and Non–Sports-Related Traumatic Brain Injury

OPENALEX - Publications

Michail Ntikas William Stewart Magdalena Ietswaart Angus M. Hunter Andrew I.R. Maas and 95 more

Importance Exposure to traumatic brain injury (TBI) has raised widespread concern over participation in sports, particularly possible long-term consequences. However, little is known about the outcomes of individuals presenting hospitals with sports-related TBI. Objective To compare characteristics and non–sports-related Design, Setting, Participants The CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research TBI) observational cohort study was conducted at 18 countries....

10.1001/jamanetworkopen.2023.53318 article EN cc-by-nc-nd JAMA Network Open 2024-01-24

Incidence, Risk Factors, and Effects on Outcome of Ventilator-Associated Pneumonia in Patients With Traumatic Brain Injury

OPENALEX - Publications

Chiara Robba Paola Rebora Erika Banzato Eveline Wiegers Nino Stocchetti and 95 more

10.1016/j.chest.2020.06.064 article EN CHEST Journal 2020-07-04

Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

OPENALEX - Publications

Ana Mikolić Suzanne Polinder Ewout W. Steyerberg Isabel R. A. Retel Helmrich Joseph T. Giacino and 95 more

The majority of traumatic brain injuries (TBIs) are categorized as mild, according to a baseline Glasgow Coma Scale (GCS) score 13-15. Prognostic models that were developed predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed validate predicting 3-12-month Outcome Extended (GOSE) or PPCS in adults with TBI. analyzed data from the Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury...

10.1089/neu.2020.7074 article EN cc-by Journal of Neurotrauma 2020-09-26

Early versus delayed cranioplasty after decompressive craniectomy in traumatic brain injury: a multicenter observational study within CENTER-TBI and Net-QuRe

OPENALEX - Publications

Rick Vreeburg Ranjit D. Singh Inge A. M. van Erp Tommi K. Korhonen John K. Yue and 95 more

OBJECTIVE The aim of this study was to compare the outcomes early (≤ 90 days) and delayed (> cranioplasty following decompressive craniectomy (DC) in patients with traumatic brain injury (TBI). METHODS authors analyzed participants enrolled Collaborative European NeuroTrauma Effectiveness Research Traumatic Brain Injury (CENTER-TBI) Neurotraumatology Quality Registry (Net-QuRe) studies who were diagnosed TBI underwent DC subsequent cranioplasty. These prospective, multicenter,...

10.3171/2024.1.jns232172 article EN Journal of neurosurgery 2024-04-27

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