Stefania Galimberti
A5036614366- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- Hematopoietic Stem Cell Transplantation
- Traumatic Brain Injury and Neurovascular Disturbances
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Mass Spectrometry Techniques and Applications
- Advanced Proteomics Techniques and Applications
- Advanced Statistical Modeling Techniques
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Statistical Methods and Bayesian Inference
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
- Cardiac Arrest and Resuscitation
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Chronic Myeloid Leukemia Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Renal Diseases and Glomerulopathies
- Endometrial and Cervical Cancer Treatments
University of Milano-Bicocca
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024-2025
Azienda Ospedaliera San Gerardo
2024-2025
Vita-Salute San Raffaele University
2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2021-2024
Heidelberg (Poland)
2018-2022
University of Hohenheim
2017-2022
Martin University
2022
The San Raffaele Telethon Institute for Gene Therapy
2021
University of Pisa
2020
Wiskott-Aldrich syndrome (WAS) is an inherited immunodeficiency caused by mutations in the gene encoding WASP, a protein regulating cytoskeleton. Hematopoietic stem/progenitor cell (HSPC) transplants can be curative, but, when matched donors are unavailable, infusion of autologous HSPCs modified ex vivo therapy alternative approach. We used lentiviral vector functional WASP to genetically correct from three WAS patients and reinfused cells after reduced-intensity conditioning regimen. All...
We investigated the long-term outcome of gene therapy for severe combined immunodeficiency (SCID) due to lack adenosine deaminase (ADA), a fatal disorder purine metabolism and immunodeficiency.
Carotid artery stenting (CAS) has recently emerged as a potential alternative to carotid endarterectomy. Cerebral embolization is the most devastating complication of CAS, and echogenicity plaque been indicated one risk factors involved. This first study analyze role computer-assisted highly reproducible index echogenicity, namely gray-scale median (GSM), on stroke during CAS.The Imaging in Angioplasty Risk Stroke (ICAROS) registry included 418 cases CAS collected from 11 international...
This phase I multicenter study was aimed at assessing the feasibility and safety of intravenous administration third party bone marrow-derived mesenchymal stromal cells (MSC) expanded in platelet lysate 40 patients (15 children 25 adults), experiencing steroid-resistant grade II to IV graft-versus-host disease (GVHD). Patients received a median 3 MSC infusions after having failed conventional immunosuppressive therapy. A cell dose 1.5 × 10(6)/kg per infusion administered. No acute toxicity...
Summary Current therapeutic regimens for acute myeloid leukaemia ( AML ) are still associated with high rates of relapse. Immunotherapy T ‐cells genetically modified to express chimeric antigen receptors CAR s) represents an innovative approach. Here we investigated the targeting interleukin three receptor alpha IL 3 RA ; CD 123) molecule, which is overexpressed on bulk population, 34 + progenitors, and stem cells LSC compared normal haematopoietic stem/progenitor HSPC s), whose...
Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary immunodeficiency characterised by microthrombocytopenia, infections, eczema, autoimmunity, and malignant disease. Lentiviral vector-mediated haemopoietic stem/progenitor cell (HSPC) gene therapy potentially curative treatment that represents an alternative to allogeneic HSPC transplantation. Here, we report safety efficacy data from interim analysis of patients with severe who received lentiviral vector-derived therapy.We...
BACKGROUND. Chimeric antigen receptor (CAR) T cell immunotherapy has resulted in complete remission (CR) and durable response highly refractory patients. However, logistical complexity high costs of manufacturing autologous viral products limit CAR availability.
In a previous analysis of 326 children with Philadelphia chromosome (Ph) -positive acute lymphoblastic leukemia (ALL) treated between 1986 and 1996, hematopoietic stem-cell transplantation from HLA-matched related donors, but not unrelated offered superior outcome than chemotherapy alone. To evaluate the impact recent improvements in transplantation, we performed similar on patients following decade.We analyzed 610 Ph-positive ALL 1995 2005 without tyrosine kinase inhibitor therapy. The...
OBJECTIVE. The objective of our study was to investigate whether apparent diffusion coefficient (ADC) values endometrial cancer differ from those normal endometrium and myometrium they vary according histologic tumor grade, the depth myometrial invasion, or lymph node status.
Allogeneic hematopoietic stem-cell transplantation is the standard of care for Hurler syndrome (mucopolysaccharidosis type I, variant [MPSIH]). However, this treatment only partially curative and associated with complications.
Long-term pulmonary sequelae following hospitalization for SARS-CoV-2 pneumonia is largely unclear. The aim of this study was to identify and characterise caused by at 12-month from discharge.
Acute myeloid leukemia (AML) is a hematological malignancy derived from neoplastic progenitor cells characterized by abnormal clonal proliferation and differentiation. Although novel therapeutic strategies have recently been introduced, the prognosis of AML remains unsatisfactory. So far, efficacy chimeric antigen receptor (CAR)-T therapy in has hampered several factors including poor accumulation blood-injected bone marrow (BM) niche, where chemotherapy-resistant leukemic stem reside. Thus,...
We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs) on brain injury biomarker profiles, acute care requirements during intensive unit (ICU) stay, 6-month outcomes in patients with traumatic (TBI). From recruited to Collaborative European neurotrauma effectiveness research TBI (CENTER-TBI) study, we documented prevalence risk factors for SIs their effect levels biomarkers [S100 calcium-binding protein B (S100B), neuron-specific enolase (NSE), neurofilament light...